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Evgeny S. Nikitin

D.Sc. in Biology, Leading Scientist

Laboratory of Cellular Neurobiology of Learning

Scopus ID
35614218800
ORCID ID
0000-0003-0149-2054
Web of Science ResearcherID
E-8330-2013

Group "Biophotonics" 

The group “Biophotonics” has been established with the support of the program of the Presidium of the Russian Academy of Sciences “Molecular and Cell Biology”. The field of research was the employment of high-speed scanning confocal microscopy in combination with classical intracellular electrophysiology to measure fast neuron activity in studies of the mechanisms of neuronal plasticity underlying the adaptation of behavior and learning. Currently, the main activity of the group is aimed at studying the regulation of excitability of neocortical pyramidal neurons  and the mechanisms of self-tuning of neuronal firing by potassium and other ion channels of the brain. These studies require the use of complex molecular-optical instruments, so the group's projects are running in collaboration with leading biochemists for the development and implementation of new genetically encoded probes of neuronal activity.

Biography 

2003 PhD, IHNA & NP, Moscow 

2003-2006 Research Fellow, University of Sussex, UK 

2006-2008 Senior Researcher, Institute of Higher Nervous Activity, Moscow Russia 

2007… 2013 Short Term Visiting Scholar, University of Connecticut, USA 

2009-present Head of Imaging Group, Institute of Higher Nervous Activity, Moscow Russia

Publication list

  1. Ierusalimsky V.N., Balaban P.M., Nikitin E.S. Nav1.6 but not KCa3.1 channels contribute to heterogeneity in coding abilities and dynamics of action potentials in the L5 neocortical pyramidal neurons. Biochemical And Biophysical Research Communications. 2022. V. 615. P. 102-108. DOI: 10.1016/j.bbrc.2022.05.050.
  2. Kost L.A., Iunusova V.A., Ivanova V.O., Nikitin E.S., Lukyanov K.A., Bogdanov A.M. The Electromotive Protein Prestin as a Sensitive Core of the Fluorescent Voltage Indicator. Russian Journal of Bioorganic Chemistry. 2022. V. 48. N. 3. P. 617-620. DOI: 10.1134/S1068162022030098.
  3. Romanova D.Y., Balaban P.M., Nikitin E.S. Sodium Channels Involved in the Initiation of Action Potentials in Invertebrate and Mammalian Neurons . Biophysica. 2022. V. 2. N. 3. P. 184-193. DOI: 10.3390/biophysica2030019.
  4. Kolesov D.V., Ivanova V.O., Sokolinskaya E.L., Kost L.A., Balaban P.M., Lukyanov K.A., Nikitin E.S., Bogdanov A.V. Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity. Molecular Biology Reports. 2021. V. 48. N. 5. P. 4549-4561. DOI: 10.1007/s11033-021-06480-0.
  5. Nikitin E.S., Vinogradova L.V. Potassium channels as prominent targets and tools for the treatment of epilepsy. Expert Opinion On Therapeutic Targets. 2021. V. 6. P. 1-13. DOI: 10.1080/14728222.2021.1908263.
  6. Ermakova Y.G., Roshchin M.V., Lanin A.A., Balaban P.M., Zheltikov A.M., Belousov V.V., Nikitin E.S. THERMOGENETICS AS A NEW METHOD TO CONTROL NEURONAL ACTIVITY. ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI IP PAVLOVA. 2020. V. 70. N. 1. P. 133-140. DOI: 10.31857/S0044467720010050.
  7. Romanova D.Y., Smirnov K.S., Nikitin E.S., Kohn A.B., Borman A.I., Malyshev A.Y., Balaban P.M., Moroz L.L. Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals. Biochemical And Biophysical Research Communications. 2020. V. 532. N. 1. P. 120-126. DOI: 10.1016/j.bbrc.2020.08.020.
  8. Roshchin M.V., Ierusalimsky V.N., Balaban P.M., Nikitin E.S. Ca(2+)-activated KCa3.1 potassium channels contribute to the slow afterhyperpolarization in L5 neocortical pyramidal neurons. Scientific Reports. 2020. V. 10. N. 1. P. 14484. DOI: 10.1038/s41598-020-71415-x.
  9. Kost L.A., Ivanova V.O., Balaban P.M., Lukyanov K.A., Nikitin E.S., Bogdanov A.M. Red Fluorescent Genetically Encoded Voltage Indicators with Millisecond Responsiveness. Sensors (Basel, Switzerland). 2019. V. 19. N. 13. P. 2982. DOI: 10.3390/s19132982.
  10. Nikitin E.S., Roschin V.Y., Ierusalimsky V.N., Egorov A.V., Balaban P.M. Optogenetic Stimulation of the Axons of Visual Cortex and Hippocampus Pyramidal Neurons in Living Brain Slices. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 2. P. 227-232. DOI: 10.1007/s11055-019-00719-x.
  11. Roshchin M.V., Ermakova Y.G., Lanin A.A., Chebotarev A.S., Kelmanson I.V., Balaban P.M., Zheltikov A.M., Belousov V.V., Nikitin E.S. Thermogenetic stimulation of single neocortical pyramidal neurons transfected with TRPV1-L channels. Neuroscience Letters. 2018. V. 687. P. 153-157. DOI: 10.1016/j.neulet.2018.09.038.
  12. Roshchin M.V., Ierusalimsky N.V., Matlashov M.V., Balaban P.M., Belousov V.V., Kemenes G., Staras K., Nikitin E.S. A BK channel–mediated feedback pathway links single-synapse activity with action potential sharpening in repetitive firing. Science Advances. 2018. V. 4. N. 7. DOI: 10.1126/SCIADV.AAT1357.
  13. Ermakova Y.G., Lanin A.A., Fedotov I.V., Roshchin M., Kelmanson I.V., Kulik D., Bogdanova Y.A., Shokhina A.G., Bilan D.S., Staroverov D.B., Balaban P.M., Fedotov A.B., Sidorov-Biryukov D.A., Nikitin E.S., Zheltikov A.M., Belousov V.V. Thermogenetic neurostimulation with single-cell resolution. Nature Communications. 2017. V. 8. P. 15362. DOI: 10.1038/ncomms15362.
  14. Kost L.A., Nikitin E.S., Ivanova V.O., Sung U., Putintseva E.V., Chudakov D.M., Balaban P.M., Lukyanov K.A., Bogdanov A.M. Insertion of the voltage-sensitive domain into circularly permuted red fluorescent protein as a design for genetically encoded voltage sensor. PLoS ONE. 2017. V. 12. N. 9. e0184225. DOI: 10.1371/journal.pone.0184225.
  15. Nikitin E.S., Bal N.V., Malyshev A.Y., Ierusalimsky V.N., Spivak Y.S., Balaban P.M., Volgushev M.A. Encoding of high frequencies improves with maturation of action potential generation in cultured neocortical neurons. Frontiers in Cellular Neuroscience. 2017. V. 11. P. 28. DOI: 10.3389/fncel.2017.00028.
  16. Nikitin E.S., Roschin V.Y., Ierusalimsky V.N., Egorov A.V., Balaban P.M. Optogenetic stimulation of axons of pyramidal neurons in acute brain slices of the visual cortex and hippocampus. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2017. V. 67. N. 5. P. 101-108. DOI: 10.7868/S0044467717050112.
  17. Nikitin E.S., Malyshev A.Y., Balaban P.M., Volgushev M.A. Physiological Aspects of the Application of Hodgkin–Huxley Model of Action Potential Initiation for Invertebrate and Vertebrate Neurons. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 3. P. 279-288. DOI: 10.7868/S0044467716030084.
  18. Matlashov M.E., Bogdanova Y.A., Ermakova G.V., Mishina N.M., Ermakova Y.G., Nikitin E.S., Balaban P.M., Okabe S., Lukyanov S.A., Enikolopov G., Zaraisky A.G., Belousov V.V. Fluorescent ratiometric pH indicator SypHer2: Applications in neuroscience and regenerative biology. Biochimica et Biophysica Acta - General Subjects. 2015. V. 1850. N. 11. P. 2318-2328. DOI: 10.1016/j.bbagen.2015.08.002.
  19. Nikitin E.S., Aseyev N.A., Balaban P.M. Advanced optical recording of neuronal activity with voltage-sensitive dyes. Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova. 2013. V. 63. N. 6. P. 656-666. DOI: 10.7868/S0044467713060129.
  20. Nikitin E.S., Balaban P.M. Compartmentalization of neral non-synaptic plasticity at subcellular level. Zhurnal vyssheǐ nervnoǐ deiatelnosti imeni I P Pavlova. 2013. V. 63. N. 3. P. 295-302. DOI: 10.7868/S0044467713030076.
  21. Aseyev N.A., Roshchin M., Ierusalimsky V.N., Balaban P.M., Nikitin E.S. Biolistic delivery of voltage-sensitive dyes for fast recording of membrane potential changes in individual neurons in rat brain slices. Journal of Neuroscience Methods. 2013. V. 212. N. 1. P. 17-27. DOI: 10.1016/j.jneumeth.2012.09.008.
  22. Nikitin E.S., Balaban P.M., Kemenes G. Nonsynaptic plasticity underlies a compartmentalized increase in synaptic efficacy after classical conditioning. Current Biology. 2013. V. 23. N. 7. P. 614-619. DOI: 10.1016/j.cub.2013.02.048.
  23. Aseyev N.A., Nikitin E.S., Roschin M.V., Ierusalimsky V.N., Balaban P.M. Fast and aimed delivery of voltage-sensitive dyes to mammalian brain slices by biolistic techniques. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2012. V. 62. N. 1. P. 100-107.
  24. Nikitin E.S., Balaban P.M. Functional organization and structure of the serotonergic neuronal network of terrestrial snail. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2011. V. 61. N. 6. P. 750-762.
  25. Vavoulis D.V., Nikitin E.S., Kemenes I., Marra V., Feng J., Benjamin P.R., Kemenes G. Balanced plasticity and stability of the electrical properties of a molluscan modulatory interneuron after classical conditioning: A computational study. Frontiers in Behavioral Neuroscience. 2010. V. 4. P. 19. DOI: 10.3389/fnbeh.2010.00019.
  26. Nikitin E.S., Korshunova T.A., Zakharov I.S., Balaban P.M. Olfactory experience modifies the effect of odour on feeding behaviour in a goal-related manner. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 2008. V. 194. N. 1. P. 19-26. DOI: 10.1007/s00359-007-0272-4.
  27. Nikitin E.S., Vavoulis D.V., Kemenes I., Marra V., Pirger Z., Michel M., Feng J., O'Shea M., Benjamin P.R., Kemenes G. Persistent Sodium Current Is a Nonsynaptic Substrate for Long-Term Associative Memory. Current Biology. 2008. V. 18. N. 16. P. 1221-1226. DOI: 10.1016/j.cub.2008.07.030.
  28. Kemenes I., Straub V.A., Nikitin E.S., Staras K., O'Shea M., Kemenes G., Benjamin P.R. Role of Delayed Nonsynaptic Neuronal Plasticity in Long-Term Associative Memory. Current Biology. 2006. V. 16. N. 13. P. 1269-1279. DOI: 10.1016/j.cub.2006.05.049.
  29. Nikitin E.S., Kiss T., Staras K., O'Shea M., Benjamin P.R., Kemenes G. Persistent sodium current is a target for cAMP-induced neuronal plasticity in a state-setting modulatory interneuron. Journal of Neurophysiology. 2006. V. 95. N. 1. P. 453-463. DOI: 10.1152/jn.00785.2005.
  30. Nikitin E.S., Zakharov I.S., Balaban P.M. Regulation of tentacle length in snails by odor concentration. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 1. P. 63-72. DOI: 10.1007/s11055-005-0163-5.
  31. Nikitin E.S., Zakharov I.S., Samarova E.I., Kemenes G., Balaban P.M. Fine tuning of olfactory orientation behaviour by the interaction of oscillatory and single neuronal activity. European Journal of Neuroscience. 2005. V. 22. N. 11. P. 2833-2844. DOI: 10.1111/j.1460-9568.2005.04480.x.
  32. Nikitin E.S., Zakharov I.S., Balaban P.M. Regulation of the length of the snail tentacle by the concentration-dependent contraction. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2004. V. 54. N. 5. P. 655-665.
  33. Norekyan T.P., Nikitin E.S., Bravarenko N.I., Malyshev A.Y., Balaban P.M. Phase-dependent coordination of two motor programs in the buccal ganglion of a pteropod mollusk. Neuroscience and behavioral physiology. 2003. V. 33. N. 2. P. 107-111. DOI: 10.1023/A:1021757411343.
  34. Norekian T.P., Nikitin E.S., Bravarenko N.I., Malyshev A.Y., Balaban P.M. Phase-dependent coordination of two motor programs in the buccal ganglion of a pteropod mollusk. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2001. V. 51. N. 6. P. 717-722.
  35. Balaban P.M., Bravarenko N.I., Maksimova O.A., Nikitin E.S., Ierusalimsky V.N., Zakharov I.S. A single serotonergic modulatory cell can mediate reinforcement in the withdrawal network of the terrestrial snail. Neurobiology of Learning and Memory. 2001. V. 75. N. 1. P. 30-50. DOI: 10.1006/nlme.1999.3953.
  36. Nikitin E.S., Balaban P.M. Optical recording of responses to odor in olfactory structures of the nervous system in the terrestrial mollusk Helix. Neuroscience and Behavioral Physiology. 2001. V. 31. N. 1. P. 21-30. DOI: 10.1023/A:1026666012225.
  37. Nikitin E.S., Balaban P.M. Optical recording of odor-evoked responses in the olfactory brain of the naive and aversively trained terrestrial snails. Learning and Memory. 2000. V. 7. N. 6. P. 422-432. DOI: 10.1101/lm.32500.
  38. Nikitin E.S., Balaban P.M. Optical recording of the odor-evoked responses in olfactory structures of the brain of the terrestrial mollusk Helix. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1999. V. 49. N. 5. P. 817-829.
 

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