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Laboratory of Functional Biochemistry of the Nervous System

Main areas of research

The study of functional and biochemical mechanisms of brain plasticity. The role of apoptotic mechanisms in the functioning of the cells of the nervous system in normal and pathological conditions. The role of nitric oxide and its synthesis systems in the brain is normal and in pathology. The study of functional and biochemical mechanisms of GNI pathologies and the development of pathogenetically directed ways to correct them.

The most important results of scientific research:

1. Neurochemical mechanisms of the effects of neurotoxins as the basis of functional disorders

On the model of neurodegeneration. caused by systemic administration of kainic acid, it has been shown that convulsive activity correlates with indicators of oxidative stress, apoptosis and expression of the AP-1 transcription factor in the rat hippocampus. On the model of limbic epilepsy caused by the systemic administration of kainic acid and accompanied by neurodegeneration, the possibility of modulating the pathological effects of zinc is shown. The zinc compound reduces the degree of convulsive activity, neuronal death and the intensity of apoptosis. The phenomenon of modulation of glutamate toxicity by zinc in vivo opens up new possibilities for the correction of pathologies mediated by this mechanism.

On the model of neurodegeneration caused by the introduction of cholinotoxin AF64A into the primary neuronal cultures of the hippocampus, cortex and septum of rat embryos, it was shown that at doses of 5-80 μM AF64A causes a delayed apoptotic neurodegeneration, most pronounced after 3 days (confirmed by morphological studies, data on cell viability and "DNA laddering"). The activity of NO synthase in cells decreased with dose and time.

2. Participation of the nitrous system and proteolytic apoptotic mechanisms in neurodegeneration during ischemia.

On the model of ischemia reproduced on organotypic cultures of the hippocampus and primary cultures of cerebellar granule cells, it was shown that changes in the generation of nitrite during ischemia depend on the culture used. The effects of ischemia on the accumulation of nitrites in cultures of cerebellar granule cells were studied. An increase in nitrite accumulation as a result of 2-hour ischemia was shown to be on average 3.6 times, followed by a decrease in reoxygenation after 2 hours and restoration of the normal level after 4 hours of reoxygenation. It is assumed that the revealed changes in nitrite accumulation reflect changes in the activity of nitric oxide synthase in cerebellar cereal cells during ischemia and reoxygenation. The effects of ischemia (oxygen-glucose deprivation) and reoxygenation on the morphology of cultured rat cerebellar seed cells and the activity of caspase-3 in these cells were studied. The total proteolytic activity increases slightly immediately after ischemia, while the specific activity of caspase-3 increases by the 4th hour of reoxygenation (during this period, morphological changes in neurons indicate their destruction). It is assumed that destructive changes in cultured nerve cells subjected to ischemia and reoxygenation are associated with the activation of caspase-3 (the data were obtained in collaboration with the laboratory of experimental neurocytology of the Research Institute of the Brain of the Russian Academy of Medical Sciences).

3. The role of the nitrative system in the effects of early social deprivation

In the brain of chickens exposed to social stress, the activity of NO synthase varies depending on the type of stress and the macrostructure studied. The activity of NO synthase increased in acute separation (in the cerebellum) and chronic separation (in all studied structures). Chronic isolation did not significantly affect the activity of the enzyme.

The early social deprivation of Octodon degus causes quantitative changes in neurons containing NADPH-diaphorase in the prefronal cortex and n. accumbens. Changes in neurons containing NADPH-diaphorase were detected in the brain of 45-day-old Octodon degus after periodic separation of suckers from the mother and early (immediately after termination of sucking) social isolation. Separation caused a decrease in the number of neurons containing NADPH-diaphorase in corpus callosum. Social isolation reduced the density of NADPH-diaphorase - containing neurons in the corpus callosum, as well as in the precentral medial cortex (only in females). The results obtained can be explained by excessive reduction of neurons containing NADPH-diaphorase, or by inhibiting the activity of this enzyme as a result of early social isolation / separation and indicate a connection between the early negative socio-emotional experience and the maturation of neurons containing NADPH-diaphorase. In Octodon degu, the enzyme activity is increased in the cerebral cortex immediately after 24 days of isolation (starting at 21 days of age). The repeated separation of the Octodon degu suckers from mothers (until the 21st day) did not have a significant effect on the activity of NO synthase in the cerebral cortex of 45-day-old animals (data obtained in collaboration with the juvenile training group of the Institute of Neurobiology, Magdeburg, Germany).

Early social stress in Wistar rats causes an increase in NO-synthase activity in the brain. 6-week isolation of male rat pups from the age of 21 days leads to an increase in the activity of NO synthase in the hippocampus of rats immediately after social stress and in the hippocampus and the cerebral cortex 10 weeks after the animals return to their normal environment from isolation.

Thus, early social isolation stress in Wistar rats and the American shrub rat Octodon degu causes an increase in the activity of NO-synthase in specific brain regions. This phenomenon, detected both immediately after social stress and in the long term, seems to mediate the long-term behavioral disturbances observed in these animals.

4. Modeling Alzheimer's Disease in Rats

A study was made of the possible connection between amnesia caused by central administration of β-amyloid (25-35) [Аβ (25-35)] and neurodegenerative changes in the hippocampus. Male Wistar rats were intracerebroventricularly administered with Aβ (25-35) at a dose of 15 nmol. 1 month after the injection, the animals were trained in an eight-arm radial labyrinth. At the end of the study, a histological study of the state of the hippocampus was performed on hematoxylin / eosin stained brain sections. Аβ (25-35) caused a violation of long-term (reference) and working memory during training in the maze. A moderate decrease in the number of neurons in the CA1 field of the hippocampus was revealed; the number of cells in the CA3 field did not change. It was found that the number of errors made by animals during training in the maze, negatively correlated with the number of nerve cells in the CA1 field of the hippocampus. Thus, for the first time, it has been demonstrated that learning and memory disorders caused by a single administration of Aβ (25-35) are specifically associated with neurodegeneration in the CA1 hippocampal field in rats.

The effect of intracerebroventricular administration of Aβ (25-35) on the reproduction of the pre-learned food searching skill in an 8-arm radial maze in rats was also investigated. Aβ (25-35) was administered bilaterally at a dose of 15 and 30 nmol / animal 7 days after prior training. Testing was performed 60 days after peptide administration. It is shown that Aβ (25-35) violates the short-term working memory in rats, without having a significant impact on the preservation of the skill. Unable to identify the dependence of memory disorders on the dose of peptide. The data presented indicate the ability of Aβ (25-35) to more impair the function of working memory than long-term memory.

Intragippocampal administration of a neurotoxic beta-amyloid fragment 25-35 at a dose of 3 nmol causes neurodegeneration, accompanied by the appearance of apoptotic nuclei, activation of astroglia and caspase-3. Tumor necrosis factor alpha, administered intracerebroventricularly at a dose of 0.5 µg, does not cause neurodegeneration, activation of astroglia and caspase-3, however, it increases neurodegeneration and activation of astroglia caused by a fragment of beta-amyloid without additional amplification of apoptosis and activation of caspase in the hippocampus. It is assumed that the enhancement of tumor necrosis factor alpha neurodegeneration processes caused by beta-amyloid fragment 25-35, is not associated with activation of apoptosis.

Preliminary results were obtained on the effects of tumor necrosis factor alpha on the behavior of rats. This cytokine does not interfere with the training of rats in the 8-arm radial maze, but it has a significant effect on the behavior in the passive avoidance test.

5. Study of the molecular mechanisms of neurodegeneration in the simulation of seizure activity.

The administration of pentyleneterazole to mice at a dose of 85 mg / kg subcutaneously causes inhibition of caspase-3 activity in the brain regions of animals. This effect of pentylenetetrazole may be associated with the development of oxidative stress in brain tissue, since, as we have shown earlier, in vitro modeling of oxidative stress by adding hydrogen peroxide dose-dependently inhibits caspase-3 activity in PC12 neuron-like cells.

Convulsive readiness caused by chronic administration of subliminal doses of a convulsant (pentylenetetrazol kindling) is accompanied by changes in the plasticity of the brain, expressed in functional (impaired learning) and structural (neurodegeneration in specific areas of the hippocampus) rearrangements. Changes in neuroplasticity are mediated by the development of oxidative stress and the activation of caspase-3 in the hippocampus.

Convulsive readiness caused by chronic administration of subliminal doses of the convulsant pentylenetetrazole (pentylenetetrazol kindling) is accompanied by changes in brain plasticity, manifested in functional (learning disruption) and structural (neurodegeneration in specific areas of the hippocampus) rearrangements. It is assumed that changes in neuroplasticity are mediated by the development of oxidative stress and activation of caspase-3 in the hippocampus. With pentylenetetrazol kindling, correlation dependences were found between the degree of neurodegeneration in the fields of the hippocampus CA1 and CA3, as well as in the dentate fascia and the severity of convulsive activity. Impaired development of active avoidance reactions also correlated with severity of convulsive activity, and neurodegeneration in the CA3 field of the hippocampus. Thus, on the model of pentylenetetrazol kindling, quantitative data were obtained for the experimental confirmation of the link between seizure activity, neurodegeneration in the hippocampus and the ability of animals to learn.

The relationship between seizure activity caused by repetitive electroshock (ES) and structural changes in the hippocampus of Balb / C mice was studied. After 2 and 7 days after completion of the EL, the brain of the animals was fixed and sections were stained according to Nissl and immunohistochemically for apoptotic nuclei (TUNEL). Additionally, the activity of the key enzyme apoptosis of caspase-3 was measured immediately in the brain regions immediately after the end of ES. The number of neurons was significantly reduced in the CA1 field and the dentate fascia, but not in the CA3 field of the hippocampus. The number of cells in CA1 and CA3 inversely correlated with the intensity of seizures. No signs of apoptotic neuronal death were detected, and caspase-3 activity was significantly reduced in the hippocampus after EL. The presented data confirm the idea of ​​functional changes in neurons after EL and deepen this idea, directly indicating a moderate (within 10%), but reliable neuron death in certain areas of the hippocampus. The inverse correlations of the number of cells with the degree of convulsive activity suggest that the main cause of neuron death is convulsions caused by EL.

6. Stroke modeling and assessment of animal neurological status.

A new method for assessing the functional state of rats after brain ischemia according to the animal's ability to pull the tongue is proposed. The results obtained using this method on the model of focal ischemia caused by occlusion of the middle cerebral artery, significantly correlate with data from other tests for neurological deficit and the size of brain infarction. The method is extremely simple and can be used as a component in a battery of tests when assessing post-ischemic functional impairments or independently when screening neuroprotective drugs and effects.

7. Development and confirmation of the hypothesis about the role of caspase-3 in the mechanisms of neuroplasticity, not associated with the death of nerve cells.

Under conditions of tumor necrosis factor-induced alpha apoptosis or phorbol-12-myristate-13-acetate-induced differentiation in cultured U-937 cells, similar activation of Ca2 + / Mg2 + -dependent nuclease was found, accompanied by activation of caspase-3 and the appearance of nucleosomal DNA fragments. The data obtained indicate that chromatin fragmentation in apoptotic and differentiating cells is carried out by the same enzymes of the apoptotic cascade (data obtained in collaboration with the Laboratory of Cell Engineering at the Institute of Theoretical and Experimental Biophysics, RAS).

In cultures of neuron-like cells PC12, apoptosis caused by hydrogen peroxide has not been shown to be accompanied by activation of caspase-3 or caspase-1. In vitro experiments have shown that caspase-3 activity in PC12 cells is dose-dependently reduced in the presence of hydrogen peroxide.

It was established that caspase-3 activity in the gopher brain naturally changes during the hibernation cycle. In the majority of the studied parts of the brain, the maximum activity is observed during the hibernation or hibernation period. Since apoptotic neuronal death in the gopher brain during the hibernation period is not described, caspase is assumed to perform a non-apoptotic function associated with plastic rearrangements of brain cells during hibernation.

Inhibition of caspase-3, a key enzyme in the apoptotic neuronal death, has been shown to block the development of NMDA-dependent long-term potentiation in rat hippocampal slices and a long-term increase in HPSP in the identified cochlear neurons during tetanization against serotonin, and also disrupts the training of active avoidance in rats. The results obtained allow us to postulate a new mechanism for the realization of the phenomena of neuroplasticity, common for vertebrates and invertebrates, including limited proteolysis of specific substrates, and suggest that caspase-3 plays a pleiotropic role in the nervous system. (represented by laboratories of functional biochemistry of the nervous system, neuroontogenesis, cellular neurobiology of learning).

Based on the results obtained, a hypothesis was formulated about the role of caspase-3 in the mechanisms of neuroplasticity that are not associated with the death of nerve cells.

Scientific experimental base. Basic methods

The laboratory is located at Leninsky Prospect, 33, box. 1. There are premises for experimental studies, isotopic block and vivarium.

The laboratory has:

  • equipment for behavioral research (installations for the study of active and passive avoidance, 8-arm and Y-shaped mazes),
  • installations for creating stress situations
  • installation for simulation of convulsive activity with maximum electroshock,
  • equipped workplaces to simulate stroke in mice and rats (occlusion of four arteries and occlusion of the middle cerebral artery),
  • stereotactic systems for the implementation of injection models of neurodegeneration,
  • equipment for pathological and immunohistochemical experiments,
  • equipment for conducting biochemical studies (optical instruments, centrifuges, equipped isotopic unit) allows, in the presence of appropriate reagents, to conduct a wide range of biochemical studies, 
    western blot equipment
  • equipment for the study of the binding of receptors with ligands.

On the existing equipment, complex studies of the behavior and neurochemical mechanisms of learning and memory are carried out in normal and pathological conditions, in particular, in modeling the neurodegeneration of various geens.

Books

  1. Gulyaeva NV, Stepanichev MYu. Biochemical correlates of individual behavior. In: Complex Brain Functions: Conceptual Advances in Russian Neuroscience. Eds. Miller R, Ivanitsky AM, Balaban PM. Australia et al., Harwood Academic Publ., 1999. P. 301-316.

Employee list

Publication list

  1. Gabova A.V., Sarkisova K.Y. Maternal MethylEnriched Diet Normalizes Characteristics of the Sleep–Wake Cycle and Sleep Spindles in Adult Offspring of WAG/Rij Rats with Genetic Absence Epilepsy. Journal of Evolutionary Biochemistry and Physiology. 2023. V. 109. N. 1. P. 75-93. DOI: 10.31857/S086981392301003X.
  2. Sarkisova K.Y., Fedosova E.A., Shatskova A.B., Rudenok M.M., Stanishevskaya V.A., Slominsky P.A. Maternal Methyl-Enriched diet increases DNMT1, HCN1, and TH Gene Expression and Suppresses Absence Seizures and Comorbid Depression in Offspring of WAG/Rij Rats. Diagnostics. 2023. V. 13. N. 398. P. 1-17. DOI: 10.3390/diagnostics13030398.
  3. Sarkisova K.Y., Gabova A.V., Fedosova E.A., Shatskova A.B., Narkevich V.B., Kudrin V.S. Antidepressant and anxiolytic effects of L-methionine in the WAG/Rij rat model of depression comorbid with absence epilepsy. International Journal of Molecular Sciences. 2023. V. 24. N. 15. P. 12425. DOI: 10.3390/ijms241512425.
  4. Fedosova E.A., Shatskova A.B., Sarkisova K.Yu. Ethosuximide improves cognitive flexibility during reversal learning in WAG/Rij rats with absence epilepsy and comorbid depression. J. Evol. Biochem. Physiol.. 2022. V. 58. N. 1. P. 98-116. DOI: 10.1134/S0022093022010100.
  5. Krylov V.V., Guekht A.B., Trifonov I.S., Magomedsultanov A.I., Navruzov R.A., Lebedeva A.V., Rider F.K., Kaimovsky I.L., Sinkin M.V., Kordonskaia O.O., Nehoroshih A.E., Yakovlev A.A. EARLY AND LONG-TERM OUTCOMES OF SURGICAL TREATMENT OF PATIENTS WITH DRUGRESISTANT EPILEPSY. Russian Neurological Journal. 2022. V. 27. N. 1. P. 52-61. DOI: 10.30629/2658-7947-2022-27-1-52-61.
  6. Pashnin E.V., Zinchuk M.S., Gersamia A.G., Voinova N.I., Yakovlev A.A., Avedisova A.S., Guekht A.B. VERIFICATION OF REASONS FOR LIVING INVENTORY IN RUSSIAN CLINICAL SAMPLE. Psikhologicheskii Zhurnal. 2022. V. 43. N. 1. P. 109-121. DOI: 10.31857/S020595920017745-5.
  7. Sarkisova K.Y., Fedosova E.A., Shatskova A.B., Narkevich V.B., Kudrin V.S. Maternal Methyl-Enriched Diet Increases Dopaminergic Tone of the Mesolimbic Brain System in Adult Offspring of WAG/Rij Rats. Doklady Biological Sciences. 2022. V. 506. N. 1. P. 145-149. DOI: 10.1134/S001249662205012X.
  8. Sarkisova K.Y., van Luijtelaar G. The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities. IBRO Neuroscience Reports. 2022. V. 13. P. 436-468. DOI: 10.1016/j.ibneur.2022.10.012.
  9. Sushkova O.S., Morozov A.A., Petrova N.G., Khokhlova M.N., Gabova A.V., Karabanov A.V., Chigaleychik L.A., Sarkisova K.Y. Method of wave train electrical activity analysis - the theoretical basis and application. Radioelektronika, Nanosistemy, Informacionnye Tehnologii. 2022. V. 14. N. 3. P. 317-330. DOI: 10.17725/rensit.2022.14.317.
  10. Yakovlev A.A. Neuroprotective Effects of Astrocyte Extracellular Vesicles in Stroke. Neurochemical Journal. 2022. V. 12. N. 2. P. 121-129. DOI: 10.1134/S1819712422020143.
  11. Zinchuk M., Kustov G., Pashnin E., Gersamia A., Rider F., Voinova N., Popova S., Sviatskaia E., Yakovlev A.A., Guekht A. Not always that EASI: Validating the Russian version of the epilepsy anxiety survey instrument and its brief counterpart. Epilepsy and Behavior. 2022. V. 133. DOI: 10.1016/j.yebeh.2022.108801.
  12. Kudryashova I.V. The Reorganization of the Actin Matrix as a Factor of Presynaptic Plasticity. neurochemistry. 2021. V. 38. N. 3. P. 195-204. DOI: 10.31857/S1027813321030092.
  13. Yakovlev A.A., Antonov V., Druzhkova T., Guekht A.B., Gulyaeva N.V. Determination of Cholesterol and Triglyceride Concentrations in Serum Extracellular Vesicles Using Commercial Kits. Biomedical Chemistry: Research and Methods. 2021. V. 4. N. 2. e00148. DOI: 10.18097/BMCRM00148.
  14. Brylev L.V., Fominykh V.V., Chernenkaia V., Chernenkiy I., Gorbachev K., Ataulina A., Izvekov A., Monakhov M., Olenichev A., Orlov S., Turin I., Loginov M., Rautbart S., Baymukanov A., Parshikov V., Demeshonok V., Yakovlev A.A., Druzhkova T., Guekht A., Gulyaeva N.V. Stress load and neurodegeneration after gastrostomy tube placement in amyotrophic lateral sclerosis patients. Metabolic Brain Disease. 2021. V. 36. N. 8. P. 2473-2482. DOI: 10.1007/s11011-021-00837-x.
  15. Fedosova E.A., Shatskova A.B., Sarkisova K.Yu. Ethosuximide Increases Exploratory Motivation and Improves Episodic Memory in the Novel Object Recognition Test in WAG/Rij Rats with Genetic Absence Epilepsy. Neuroscience and Behavioral Physiology. 2021. V. 51. N. 4. P. 501-512. DOI: 10.1007/s11055-021-01097-z.
  16. Karan A.A., Spivak Y.S., Gerasimov K.A., Suleymanova E.M., Volobueva M.N., Kvichanskiy A.A., Vinogradova L.V., Bolshakov A.P. CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex. Molecular Neurobiology. 2021. DOI: 10.1007/s12035-021-02395-w.
  17. Krylov V.V., Gekht A.B., Trifonov I.S., Lebedeva A.V., Rider F.K., Kaimovsky I.L., Sinkin M.V., Kordonskaya O.O., Magomedsultanov A.I., Navruzov R.A., Yakovlev A.A., Grigorieva E.V., Mamulashvili G.V. Long-term postoperative outcomes in patients with drug-resistant epilepsy. Zhurnal Voprosy Nejrokhirurgii Imeni N.N. Burdenko. 2021. V. 85. N. 5. P. 6-14. DOI: 10.17116/neiro2021850516.
  18. Kudryashova I.V. The Reorganization of the Actin Matrix as a Factor of Presynaptic Plasticity. Neurochemical Journal. 2021. V. 15. N. 3. P. 217-225. DOI: 10.1134/S1819712421030089.
  19. Kustov G.V., Zinchuk M.S., Gersamija A.G., Voinova N.I., Yakovlev A.A., Avedisova A.S., Guekht A.B. Psychometric properties of the Russian version of the brief «Reasons for Living Inventory». Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2021. V. 121. N. 10. P. 87-94. DOI: 10.17116/jnevro202112110187.
  20. Peregud D., Stepanichev M.Yu., Gulyaeva N.V. Expression of the hippocampal PTCH during early abstinence is associated with drinking patterns in a rat model of voluntary alcohol intake. Neuroreport. 2021. V. 32. N. 9. P. 757-761. DOI: 10.1097/WNR.0000000000001646.
  21. Sinkin M.V., Talypov A.E., Yakovlev A.A., Kordonskaya O.O., Teplyshova A.M., Trifonov I.S., Guekht A.B., Krylov V.V. Long-term eeg monitoring in patients with acute traumatic brain injury. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2021. V. 121. N. 5. P. 62-67. DOI: 10.17116/jnevro202112105162.
  22. Stepanichev M.Y., Goryakina T., Manolova A., Lazareva N., Kvichanskii A., Tretyakova L., Volobueva M., Gulyaeva N. Neonatal proinflammatory challenge evokes a microglial response and affects the ratio between subtypes of GABAergic interneurons in the hippocampus of juvenile rats: sex-dependent and sex-independent effects. Brain Structure and Function. 2021. V. 226. N. 2. P. 563-574. DOI: 10.1007/s00429-020-02199-z.
  23. Zinchuk M., Kustov G., Pashnin E., Gersamia A., Rider F., Yakovlev A.A., Voinova N., Popova S., Avedisova A., Guekht A. Validation of the Generalized Anxiety Disorder-7 (GAD-7) in Russian people with epilepsy. Epilepsy &amp; Behavior. 2021. V. 123. P. 108269. DOI: 10.1016/j.yebeh.2021.108269.
  24. Zinchuk M.S., Kustov G., Pashnin E., Pochigaeva K., Rider F., Yakovlev A.A., Hesdorffer D., Hauser A.W., Guekht A. Interictal dysphoric disorder in people with and without epilepsy. . Epilepsia. 2021. V. 62. P. 1382-1390. DOI: 10.1111/epi.16902.
  25. Kudryashova I.V. Presynaptic LTP in blockade of NMDA2B receptors. Zhurn vyssh nervn deyat. 2020. V. 70. N. 1. P. 115-124. DOI: 10.31857/S0044467720010074.
  26. Yakovlev A.A., Druzhkova T., Guekht A.B., Gulyaeva N.V. Sensitivity of Extracellular Vesicles from Human Blood Serum to Various Detergents. Biomedical Chemistry: Research and Methods. 2020. V. 3. N. 4. e00143. DOI: 10.18097/BMCRM00143.
  27. Bolshakov A.P., Stepanichev M.Y., Dobryakova Y.V., Spivak Y.S., Markevich V.A. Saporin from Saponaria officinalis as a Tool for Experimental Research, Modeling, and Therapy in Neuroscience. Toxins. 2020. V. 12. N. 9. P. 546. DOI: 10.3390/toxins12090546.
  28. Brylev L.V., Ataulina A., Fominykh V.V., Parshikov V., Vorobyeva A., Istomina E., Shikhirimov R., Salikov A., Zakharova M., Guekht A., Beghi E. The epidemiology of amyotrophic lateral sclerosis in Moscow (Russia). Amyotrophic Lateral Sclerosis &amp; Frontotemporal Degeneration. 2020. V. 21. N. 5-6. P. 410-415. DOI: 10.1080/21678421.2020.1752252.
  29. Kudryashova I., Stepanichev M., Manolova A., Gulyaeva N. Deficit of Long-Term Potentiation Induction, but Not Maintenance, in the Juvenile Hippocampus after Neonatal Proinflammatory Stress. Developmental Neuroscience. 2020. V. 41. N. 5-6. P. 318-326. DOI: 10.1159/000507347.
  30. Kudryashova I.V. Presynaptic LTP in Blockade of NMDA2B Receptors. Neuroscience and Behavioral Physiology. 2020. V. 50. N. 8. P. 1005-1011. DOI: 10.1007/s11055-020-00999-8.
  31. Kudryashova I.V., Stepanichev M.Yu., Gulyaeva N.V. Neonatal Proinflammatory Stress and the Maturation of Intercellular Communication in the Hippocampus. Neuroscience and Behavioral Physiology. 2020. V. 50. N. 6. P. 730-742. DOI: 10.1007/s11055-020-00971-6.
  32. Peregud D.I., Stepanichev M.Yu., Gulyaeva N.V. Drinking Pattern in Intermittent Access Two-Bottle-Choice Paradigm in Male Wistar Rats Is Associated with Exon-Specific BDNF Expression in the Hippocampus During Early Abstinence. Journal Of Molecular Neuroscience. 2020. V. 71. N. 2. P. 262-275. DOI: 10.1007/s12031-020-01645-1.
  33. Rovnyagina N.R., Budylin G.S., Vainer Y.G., Tikhonova T.N., Vasin S.L., Yakovlev A.A., Kompanets V.O., Chekalin S.V., Priezzhev A.V., Shirshin E.A. Fluorescence Lifetime and Intensity of Thioflavin T as Reporters of Different Fibrillation Stages: Insights Obtained from Fluorescence Up-Conversion and Particle Size Distribution Measurements. International Journal Of Molecular Sciences. 2020. V. 21. N. 17. P. 6169. DOI: 10.3390/ijms21176169.
  34. Sarkisova K.Y., Gabova A.V., Fedosova E.A., Shatskova A.B. Gender-Dependent Effect of Maternal Methyl-Enriched Diet on the Expression of Genetic Absence Epilepsy and Comorbid Depression in Adult Offspring of WAG/Rij Rats. Doklady Biological Sciences. 2020. V. 494. N. 1. P. 244-247. DOI: 10.1134/S0012496620050075.
  35. Stepanichev M.Yu. Gene Editing and Alzheimer's Disease: Is There Light at the End of the Tunnel?. Frontiers in Genome Editing. 2020. V. 2. P. 4. DOI: 10.3389/fgeed.2020.00004.
  36. Zinchuk M., Beghi M., Beghi E., Bianchi E., Avedisova A., Yakovlev A.A., Guekht A. Non-Suicidal Self-Injury in Russian Patients with Suicidal Ideation. Archives Of Suicide Research. 2020. V. 27. P. 1-25. DOI: 10.1080/13811118.2020.1833801.
  37. Zinchuk M., Kustov G., Pashnin E., Gersamia A., Rider F., Yakovlev A.A., Guekht A. Validation of the Russian version of neurological disorders depression inventory for epilepsy (NDDI-E). Epilepsy &amp; Behavior. 2020. V. 113. P. 107549. DOI: 10.1016/j.yebeh.2020.107549.
  38. Yakovlev A.A., Druzhkova T.A., Nikolaev R.V., Kuznetsova V.E., Gruzdev S.K., Guekht A.B., Gulyaeva N.V. Elevated Levels of Serum Exosomes in Patients with Major Depressive Disorder. Neurochemical Journal. 2019. V. 36. N. 4. P. 346-352. DOI: 10.1134/S1027813319040046.
  39. Yakovlev A.A., Lyzhin A.A., Aleksandrova O.P., Khaspekov L.G., Gulyaeva N.V. Exosomes secretion and autophagy in long-term protection of neurons from excitotoxic damage. Biomeditsinskaya Khimiya. 2019. V. 65. N. 5. P. 361-365. DOI: 10.18097/PBMC20196505361.
  40. Averchenkov D.M., Bejsheeva M.T., Ivakina E.D., Fominykh V.V., Grazhdantseva L.Y., Ivashchenko R.A., Arzumanian N.S., Brylev L.V., Guekht A.B. Clinical case of levamisole-induced multifocal inflammatory leukoencephalopathy. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2019. V. 119. N. 12. P. 106-114. DOI: 10.17116/jnevro2019119121106.
  41. Druzhkova T., Pochigaeva K., Yakovlev A.A., Gersamia A., Guekht A., Gulyaeva N.V. Effects of Childhood Trauma on the Biological Correlates of Stress in Men and Women with Borderline Mental Disorders. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 7. P. 916-920. DOI: 10.1007/s11055-019-00819-8.
  42. Fominykh V.V., Brylev L.V., Gaskin V., Luzin R., Yakovlev A.A., Komoltsev I., Belousova I., Rosliakova A., Guekht A., Gulyaeva N.V. Neuronal damage and neuroinflammation markers in patients with autoimmune encephalitis and multiple sclerosis. Metabolic Brain Disease. 2019. V. 34. N. 5. P. 1473-1485. DOI: 10.1007/s11011-019-00452-x.
  43. Gruzdev S.K., Yakovlev A.A., Druzhkova T.A., Guekht A.B., Gulyaeva N.V. The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia. Cellular And Molecular Neurobiology. 2019. V. 39. N. 6. P. 729-750. DOI: 10.1007/s10571-019-00684-6.
  44. Kvichanskiy A.A., Volobueva M.N., Spivak Y.S., Tretyakova L.V., Gulyaeva N.V., Bolshakov A.P. Expression of mRNAs for IL-1β, IL-6, IL-10, TNFα, CX3CL1, and TGFβ1 Cytokines in the Brain Tissues: Assessment of Contribution of Blood Cells with and without Perfusion. Biochemistry (Moscow). 2019. V. 84. N. 8. P. 905-910. DOI: 10.1134/S0006297919080066.
  45. Leo A., Citraro R., Tallarico M., Iannone M., Fedosova E.A., Nesci V., de Sarro G., Sarkisova K.Y., Russo E. Cognitive impairment in the WAG/Rij rat absence model is secondary to absence seizures and depressive-like behavior. Progress in Neuropsychopharmacology & Biological Psychiatry. 2019. V. 94. N. 109652. DOI: 10.1016/j.pnpbp.2019.109652.
  46. Martianova E., Aniol V.A., Manolova A.O., Kvichansky A.A., Gulyaeva N.V. Activation of microglia associated with lentiviral transduction: A semiautomated method of assessment. Acta Histochemica. 2019. V. 121. N. 3. P. 368-375. DOI: 10.1016/j.acthis.2019.01.008.
  47. Skalnaya A., Fominykh V.V., Ivashchenko R., Averchenkov D., Grazhdantseva L., Frigo N., Negasheva E., Dolya O., Brylev L.V., Guekht A. Neurosyphilis in the modern era: Literature review and case series. Journal Of Clinical Neuroscience. 2019. V. 69. P. 67-73. DOI: 10.1016/j.jocn.2019.08.033.
  48. Gabova A.V., Sarkisova K.Y., Fedosova E.A., Shatskova A.B., Morozov A.A. Age-related changes of spike-wave discharges in WAG/Rij rats with genetic absence epilepsy. Russian Journal of Physiology. 2018. V. 104. N. 10. P. 1176-1189. DOI: 10.7868/S0869813918100052.
  49. Druzhkova T.A., Yakovlev A.A. Exosome Drug Delivery Through The Blood–Brain Barrier:Experimental Approaches And Potential Applications. Neurochemical Journal. 2018. V. 35. N. 3. P. 201-211. DOI: 10.1134/S1027813318030032.
  50. Dobryakova Y.V., Kasianov A., Zaichenko M.I., Stepanichev M.Y., Chesnokova E.A., Kolosov P.M., Markevich V.A., Bolshakov A.P. Intracerebroventricular administration of <sup>192</sup>IgG-saporin alters expression of microglia-associated genes in the dorsal but not ventral hippocampus. Frontiers in Molecular Neuroscience. 2018. V. 10. P. 429. DOI: 10.3389/fnmol.2017.00429.
  51. Druzhkova T., Pochigaeva K., Yakovlev A.A., Kazimirova E., Grishkina M., Chepelev A., Guekht A., Gulyaeva N.V. Acute stress response to a cognitive task in patients with major depressive disorder: potential metabolic and proinflammatory biomarkers. Metabolic Brain Disease. 2018. V. 34. N. 2. P. 621-629. DOI: 10.1007/s11011-018-0367-3.
  52. Fominykh V.V., Vorobyeva A., Onufriev M.V., Brylev L.V., Zakharova M.N., Gulyaeva N.V. Interleukin-6, S-Nitrosothiols, and Neurodegeneration in Different Central Nervous System Demyelinating Disorders: Is There a Relationship?. Journal Of Clinical Neurology (Seoul, Korea). 2018. V. 14. N. 3. P. 327-332. DOI: 10.3988/jcn.2018.14.3.327.
  53. Loseva E.V., Loginova N.A., Sarkisova K.Y., Klodt P.M., Narkevich V.B., Kudrin V.S. Behavioral Symptoms of Anxiety and Depression and Brain Monoamine Contents in Rats after Chronic Intranasal Administration of Interferon-α. Neuroscience and Behavioral Physiology. 2018. V. 48. N. 8. P. 954-962. DOI: 10.1007/s11055-018-0655-8.
  54. Mazarati A., Jones N.C., Galanopoulou A.S., Harte-Hargrove L.C., Kalynchuk L.E., Lenck-Santini P.-., Medel-Matus J.-., Nehlig A., DeLaPrida L.M., Sarkisova K.Y., Veliskova J. A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force. Epilepsia Open. 2018. V. 3. P. 24-52. DOI: 10.1002/epi4.12236.
  55. Sarkisova K.Y., Gabova A.V. Maternal care exerts disease-modifying effects on genetic absence epilepsy and comorbid depression. Genes, Brain and Behavior. 2018. V. 17. N. 7. e12477. DOI: 10.1111/gbb.12477.
  56. Shpak A.A., Guekht A.B., Druzhkova T.A., Kozlova K.I., Gulyaeva N.V. Brain-Derived Neurotrophic Factor in Patients with Primary Open-Angle Glaucoma and Age-related Cataract. Current Eye Research. 2018. V. 43. N. 2. P. 224-231. DOI: 10.1080/02713683.2017.1396617.
  57. Stepanichev M.Yu., Manolova A.O., Peregud D.I., Onufriev M.V., Freiman S., Aniol V.A., Moiseeva Y.V., Novikova M.R., Lazareva N.A., Gulyaeva N.V. Specific Activity Features in the Forced Swim Test: Brain Neurotrophins and Development of Stress-induced Depressive-like Behavior in Rats. Neuroscience. 2018. V. 375. P. 49-61. DOI: 10.1016/j.neuroscience.2018.02.007.
  58. Fominykh V.V., Shevtsova T., Arzumanian N., Brylev L.V. Coexistence of multiple sclerosis and ankylosing spondylitis: Report of four cases from Russia and review of the literature. Journal Of Clinical Neuroscience. 2017. V. 44. P. 230-233. DOI: 10.1016/j.jocn.2017.06.031.
  59. Grigoryan G.A., Gulyaeva N.V. Modeling Depression in Animals: Behavior as the Basis for the Methodology, Assessment Criteria, and Classification. Neuroscience and Behavioral Physiology. 2017. V. 47. N. 2. P. 204-216. DOI: 10.1007/s11055-016-0386-7.
  60. Guekht A., Gersamiya A., Kaimovskiy I., Mizinova M., Yakovlev A.A., Shpak A. Attitudes towards people with epilepsy in Moscow. Epilepsy &amp; Behavior. 2017. V. 70. N. Pt A. P. 182-186. DOI: 10.1016/j.yebeh.2017.03.020.
  61. Ivanova O.Y., Dobryakova Y.V., Salozhin S.V., Aniol V.A., Onufriev M.V., Gulyaeva N.V., Markevich V.A. Lentiviral Modulation of Wnt/β-Catenin Signaling Affects In Vivo LTP. Cellular and Molecular Neurobiology. 2017. V. 37. N. 7. P. 1227-1241. DOI: 10.1007/s10571-016-0455-z.
  62. Kukushkin M.L., Brylev L.V., Laskov V.B., Makarov N.S., Pizova N.V., Sokov E.L., Chefranova Z.Y., Sholomov I.I., Guekht A.B. Results of a randomized double blind parallel study on the efficacy and safety of tolpersione in patients with acute nonspecific low back pain. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2017. V. 117. N. 11. P. 69-78. DOI: 10.17116/jnevro201711711169-78.
  63. Kvichansky A.A., Volobueva M.N., Manolova A.O., Bolshakov A.P., Gulyaeva N.V. Neonatal proinflammatory stress alters the expression of genes of corticosteroid receptors in the rat hippocampus: Septo-temporal differences. Neurochemical Journal. 2017. V. 11. N. 3. P. 255-258. DOI: 10.1134/S1819712417030059.
  64. Pochigaeva K., Druzhkova T., Yakovlev A.A., Onufriev M.V., Grishkina M., Chepelev A., Guekht A., Gulyaeva N.V. Hair cortisol as a marker of hypothalamic-pituitary-adrenal Axis activity in female patients with major depressive disorder. Metabolic Brain Disease. 2017. V. 32. N. 2. P. 577-583. DOI: 10.1007/s11011-017-9952-0.
  65. Sarkisova K.Y., Fedotova I.B., Surina N.M., Nikolaev G.M., Perepelkina O.V., Kostina Z.A., Poletaeva I.I. Genetic background contributes to the co-morbidity of anxiety and depression with audiogenic seizure propensity and responses to fluoxetine treatment. Epilepsy and Behavior. 2017. V. 68. P. 95-102. DOI: 10.1016/j.yebeh.2016.12.025.
  66. Sarkisova K.Y., Fedotova I.R., Surina N.M., Nikolaev G.M., Perepelkina O.V., Kostina Z.A., Poletaeva I.I. Genetic background contributes to the co-morbidity of anxiety and depression with audiogenic seizure propensity and responses to fluoxetine treat. Epilepsy Behav.. 2017. V. 68. P. 95-102. DOI: 10.1016/j.yebeh.20162016.12.025.
  67. Sarkisova K.Y., Gabova A.V., Kulikov M.A., Fedosova E.A., Shatskova A.B., Morosov A.A. Rearing by foster Wistar mother with high level of maternal care counteracts the development of genetic absence epilepsy and comorbid depression in WAG/Rij rats. Doklady Biological Sciences. 2017. V. 473. N. 1. P. 39-42. DOI: 10.1134/S0012496617020077.
  68. Sokhranyaeva L.S., Aniol V.A., Gulyaeva N.V. Epigenetic modifications of chromatin in epilepsy: A potential mechanism of pharmacoresistance?. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2017. V. 117. N. 9. P. 17-21. DOI: 10.17116/jnevro20171179217-21.
  69. Stepanichev M.Yu., Onufriev M., Aniol V.A., Freiman S., Brandstaetter H., Winter S., Lazareva N., Guekht A., Gulyaeva N.V. Effects of cerebrolysin on nerve growth factor system in the aging rat brain. Restorative Neurology and Neuroscience. 2017. V. 35. N. 6. P. 571-581. DOI: 10.3233/RNN-170724.
  70. Yakovlev A.A., Lyzhin A.A., Khaspekov L.G., Guekht A.B., Gulyaeva N.V. Peptide drug cortexin inhibits brain caspase-8. Biomeditsinskaya Khimiya. 2017. V. 63. N. 1. P. 27-31. DOI: 10.18097/PBMC20176301027.
  71. Aniol V.A. Effect of formaline prolonged fixation on immunohistochemical painting of PCNA and Dcx proteins in mice hippocampus. Nejrokhimija. 2016. V. 33. N. 3. P. 258-262.
  72. Aniol V.A., Tishkina A.O., Gulyaeva N.V. Neurogenesis and neuroinflammation: role of Wnt proteins. Nejrokhimija. 2016. V. 33. N. 1. P. 5-11.
  73. Aniol V.A., Tishkina A.O., Salozhin S.V., Kvichanskiy A.A., Gulyaeva N.V. Suppression of postnatal neurogenesis in ra's hippocampus under activity of lentiviral transduction Wnt3. Nejrokhimija. 2016. V. 33. N. 4. P. 301-309.
  74. Gerasimovich E.S., Yakovlev A.A., Druzhkova T.A., Grishkina M.N., Gekht A.B., Gulyaeva N.V. Activation of caspases in limphocytes of patients with border psychic disorders. Biomeditsynskaja Khimija. 2016. V. 62. N. 1. P. 89-92.
  75. Gersamia A.G., Menshikova A.A., Yakovlev A.A. Stress in childhood and psychological pecularities of humans under affective disorders. Eksperimentalnaja psikhologija. 2016. V. 9. N. 3. P. 103-117. DOI: 10.17759/exppsy.2016090308.
  76. Gulyaeva N.V. Brain plasticity and connectopathy: mechanisms of comorbidity of neurological diseases and depression. Zhurnal Nevropatologii i Psikhiatrii im Korsakova. 2016. V. 1. N. 1. P. 1-100. DOI: 10.17116/jnevro2016116111.
  77. Zinchuk M.S., Gekht A.B., Gulyaeva N.V., Avedisova A.S., Akzhigitov R.S., Grishkina M.N. Biological foundations of suicides. Zhurnal Nevrologii i Psikhiatrii im S S Korsakova. 2016. V. 116. N. 8. P. 94-101.
  78. Kudryashova I.V., Gulyaeva N.V. "Unpredictable stress": disambiguity of stress-reactivity when investigating long-term plasticity. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 4. 414–428.
  79. Onufriev M.V., Semenova T.P., Volkova E.P., Sergunkina M.A., Yakovlev A.A., Zakharova N.M., Gulyaeva N.V. Seasonal pecularitief of actine expression and CDK5 protein in different brain regions of Yakute gopher (Spermophilus Undulatus). Nejrokhimija. 2016. V. 33. N. 2. P. 103-111.
  80. Onufriev M.V., Semenova T.P., Volkova E.P., Yakovlev A.A., Sergulskaja M.A., Zakharova N.M., Gulyaeva N.V. Features of the expression of CDK1 protein and cyclin B1 in the brain of Yakut gophers (Spermophilus undulatus) at different stages of the hibernation cycle. Nejrokhimija. 2016. V. 33. N. 2. P. 112-121.
  81. Peregud D.I., Panchenko L.F., Gulyaeva N.V. Micro RNA can regulate level of brain neurotrophic factor in rat's frontal cortex under spontaneous cancellation of morphine. Nejrokhimija. 2016. V. 33. N. 4. 323–331.
  82. Peregud D.I., Stepanichev M.Y., Lazareva N.A., Panchenko L.F., Gulyaeva N.V. Influence of single injection of neurotrophic factor into mid tire area on supporting properties of morphine. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 5. 632–640.
  83. Peregud D.I., Freiman S.V., Tishkina A.O., Sokhranyaeva L.S., Lazareva N.A., Onufriev M.V., Stepanichev M.Y., Gulyaeva N.V. Effects of early neonatal proinflammatory stress on the expression of BDNF transcripts in the brain regions of prepubertal male rats. Vavilovskij Zhurnal Genetiki i Selektsii. 2016. V. 20. N. 2. P. 191-197.
  84. Sarkisova K.Y., Tanaeva K.K., Dobryakova Y.V. Conditional reaction of place choice associated with chidren and mother care for depressive WAG/Rij rats. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 2. P. 229-241.
  85. Sarkisova K.Y., Fedotova I.R., Surina N.M., Nikolaev G.M., Perepelkina O.V., Poletaeva I.I. The effect of chronic fluoxetine administration on audiogenic epilepsy, symptoms of anxiety and depression in four rats. Doklady Akademii Nauk. 2016. V. 467. N. 2. P. 238-241.
  86. Stepanichev M.Y., Ivanov A.D., Lazareva N.A., Moiseeva Y.V., Gulyaeva N.V. Neurodegenerative changes caused by the introduction of a fragment (25–35) of a β-amyloid peptide into the hippocampus are associated with activation of NGF signaling. Vestnik RGMU. 2016. V. 1. N. 1. P. 14-19.
  87. Stepanichev M.Y., Markov D.A., Freiman S.V., Frolova O.A., Omeljanchik S.N., Borodina T.A., Novikova M.R., Kanunnikova N.P., Onufriev M.V., Mojseenok A.G., Gulyaeva N.V. Pantothenic acid derivatives when used with memantine reduce scopolamine-induced amnesia in rats: participation of the redox state of thiols and coenzyme A. Nejrokhimija. 2016. V. 33. N. 2. P. 128-139.
  88. Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshyna I.P., Piskunov A.K., Lazareva N.A., Gulyaeva N.V. Effects of Chronic Combined Stress: Changes in the Behavior of Rats with a Different Reaction to Novelty. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 5. P. 611-625.
  89. Tishkina A.O., Mart'yanova E.K., Logashina Y.A., Andreev Y.A., Khaibullina S.F., Rizvanov A.A., Gulyaeva N.V., Grishin E.V. Effects of intranasal administration of the peptide antagonist of type I vaniloid receptor (TRPV1) in the rodent central nervous system. Doklady Biological Sciences. 2016. V. 470. N. 1. P. 234-236. DOI: 10.7868/S086956521627030X.
  90. Freiman S.V., Onufriev M.V., Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Gulyaeva N.V. Stressogenic effects of a single injection of saline: systemic (blood) and central (frontal cortex, dorsal and ventral hippocampus). Najrokhimija. 2016. V. 33. N. 2. P. 122-127.
  91. Shpak A.A., Gekht A.B., Druzhkova T.A., Kozlova K.I., Golovin A.V., Gulyaeva N.V. Neurotrophic factor of the brain in patients with age-related cataract. Nejrokhimija. 2016. V. 33. N. 3. P. 253-257.
  92. Yakovlev A.A., Gulyaeva N.V. Cortexin's molecular partners in the brain. Nejrokhimija. 2016. V. 33. N. 4. P. 1-6.
  93. Yakovlev A.A., Druzhkova T.A., Grishkina M.N., Guekht A.B., Gulyaeva N.V. Caspase activity in peripheral blood mononuclear cells (PBMC) of patients with depression and anxiety of different severity. Biomeditsinskaya Khimiya. 2016. V. 62. N. 5. P. 588-592. DOI: 10.18097/PBMC20166205588.
  94. Yakovlev A.A., Lyzhin A.A., Aleksandrova O.P., Khaspekov L.G., Gulyaeva N.V. Trophic factors deprivation induces long-term protection of neurons against excitotoxic damage. Biomeditsinskaya Khimiya. 2016. V. 62. N. 6. P. 656-663. DOI: 10.18097/PBMC20166206656.
  95. Aniol V.A. The effects of prolonged formalin fixation on immunohistochemical staining of PCNA and Dcx proteins in the mouse hippocampus. Neurochemical Journal. 2016. V. 10. N. 3. P. 244-247. DOI: 10.1134/S181971241603003X.
  96. Aniol V.A., Guekht A.B., Gulyaeva N.V. Single seizure and cognition: clinical and translational implications. ARC Journal of Neuroscience. 2016. V. 1. N. 2. P. 4-18. DOI: 10.20431/2456-057x.0102002.
  97. Aniol V.A., Tishkina A.O., Gulyaeva N.V. Neurogenesis and neuroinflammation: The role of Wnt proteins. Neurochemical Journal. 2016. V. 10. N. 1. P. 1-6. DOI: 10.1134/S1819712415040030.
  98. Aniol V.A., Tishkina A.O., Salozhin S.V., Kvichanskii A.A., Gulyaeva N.V. Suppression of adult hippocampal neurogenesis due to Wnt3a lentivirus transduction. Neurochemical Journal. 2016. V. 10. N. 4. P. 280-287. DOI: 10.1134/S1819712416040024.
  99. Bondarenko E.A., Shadrina M.I., Grishkina M.N., Druzhkova T.A., Akzhigitov R.G., Gulyaeva N.V., Guekht A.B., Slominsky P.A. Genetic analysis of BDNF, GNB3, MTHFR, ACE and APOE variants in major and recurrent depressive disorders in Russia. International Journal of Medical Sciences. 2016. V. 13. N. 12. P. 977-983. DOI: 10.7150/ijms.16642.
  100. Fominykh V., Onufriev M.V., Vorobyeva A., Brylev L., Yakovlev A.A., Zakharova M.N., Gulyaeva N.V. Increased S-nitrosothiols are associated with spinal cord injury in multiple sclerosis. Journal of Clinical Neuroscience. 2016. V. 28. P. 38-42. DOI: 10.1016/j.jocn.2015.09.017.
  101. Freiman S.V., Onufriev M.V., Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Gulyaeva N.V. The stress effects of a single injection of isotonic saline solution: systemic (blood) and central (frontal cortex and dorsal and ventral hippocampus). Neurochemical Journal. 2016. V. 10. N. 2. P. 115-119. DOI: 10.1134/S1819712416020033.
  102. Gerasimovich E.S., Yakovlev A.A., Druzhkova T.A., Grishkina M.N., Guekht A.B., Gulyaeva N.V. Activation of caspases in lymphocytes of patients with borderline personality disorders. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2016. V. 10. N. 3. P. 246-250. DOI: 10.1134/S1990750816030021.
  103. Gulyaeva N.V. Studies on stress-induced modulation of long term potentiation in rodent hippocampus: What can we learn about pathogenesis of depression?. Translational Brain Rhythmicity. 2016. V. 1. P. 1. DOI: 10.15761/TBR.1000107.
  104. Onufriev M.V., Semenova T.P., Volkova E.P., Sergun'kina M.A., Yakovlev A.A., Zakharova N.M., Gulyaeva N.V. Seasonal changes in actin and Cdk5 expression in different brain regions of the Yakut ground squirrel (Spermophilus undulatus). Neurochemical Journal. 2016. V. 10. N. 2. P. 98-105. DOI: 10.1134/S1819712416020070.
  105. Onufriev M.V., Semenova T.P., Volkova E.P., Sergun'kina M.A., Yakovlev A.A., Zakharova N.M., Gulyaeva N.V. The characteristics of the expression of the Cdk1 and Cyclin B1 Proteins in the brain of the Yakut ground squirrel (Spermophilus undulatus) at different stages of the hibernation cycle. Neurochemical Journal. 2016. V. 10. N. 2. P. 106-114. DOI: 10.1134/S1819712416020082.
  106. Peregud D.I., Yakovlev A.A., Stepanichev M.Y., Onufriev M.V., Panchenko L.F., Gulyaeva N.V. Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent. Cellular and Molecular Neurobiology. 2016. V. 36. N. 6. P. 839-849. DOI: 10.1007/s10571-015-0267-6.
  107. Piskunov A., Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshina I., Gulyaeva N.V. Chronic combined stress induces selective and long-lasting inflammatory response evoked by changes in corticosterone accumulation and signaling in rat hippocampus. Metabolic Brain Disease. 2016. V. 31. N. 2. P. 445-454. DOI: 10.1007/s11011-015-9785-7.
  108. Sarkisova K.Y., Fedotova I.R., Surina N.M., Nikolaev G.M., Perepelkina O.V., Poletaeva I.I. Effect of chronic fluoxetine treatment on audiogenic epilepsy, symptoms of anxiety and depression in rats of four lines. Doklady Biological Sciences. 2016. V. 467. N. 1. P. 55-58. DOI: 10.1134/S0012496616020058.
  109. Stepanichev M.Y., Markov D., Pasikova N.V., Gulyaeva N.V. Behavior and the cholinergic parameters in olfactory bulbectomized female rodents: Difference between rats and mice. Behavioural Brain Research. 2016. V. 297. P. 5-14. DOI: 10.1016/j.bbr.2015.09.033.
  110. Stepanichev M.Y., Markov D., Pasikova N.V., Gulyaeva N.V. Behavior and the cholinergic parameters in olfactory bulbectomized female rodents: Difference between rats and mice. Behavioural Brain Research. 2016. V. 297. P. 5-14. DOI: 10.1016/j.bbr.2015.09.033.
  111. Stepanichev M.Y., Markov D.A., Freiman S.V., Frolova O.A., Omelyanchik S.N., Borodina T.A., Novikova M.R., Kanunnikova N.P., Onufriev M.V., Moiseenok A.G., Gulyaeva N.V. Combined treatment with pantothenic acid derivatives and memantine alleviates scopolamine-induced amnesia in rats: The involvement of the thiol redox state and coenzyme A. Neurochemical Journal. 2016. V. 10. N. 2. P. 120-130. DOI: 10.1134/S1819712416020094.
  112. Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshina I.P., Freiman S.V., Onufriev M.V., Levchenko O.A., Lazareva N.A., Gulyaeva N.V. Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms. Acta Neurobiologiae Experimentalis. 2016. V. 76. N. 4. P. 324-333. DOI: 10.21307/ane-2017-031.
  113. Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshina I.P., Freiman S.V., Onufriev M.V., Levchenko O.A., Lazareva N.A., Gulyaeva N.V. Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms. Acta Neurobiologiae Experimentalis. 2016. V. 76. N. 4. P. 324-333. DOI: 10.21307/ane-2017-031.
  114. Tishkina A.O., Stepanichev M.Y., Kudryashova I.V., Freiman S., Onufriev M.V., Lazareva N.A., Gulyaeva N.V. Neonatal proinflammatory challenge in male Wistar rats: Effects on behavior, synaptic plasticity, and adrenocortical stress response. Behavioural Brain Research. 2016. V. 304. P. 1-10. DOI: 10.1016/j.bbr.2016.02.001.
  115. Aniol V.A., Gulyaeva N.V. Changes in postnatal neurogenesis in hippocampus terminative zone in humans after depressive spectrum disorders. Nejrokhimija. 2015. V. 32. N. 1. P. 13-18.
  116. Balaban P.M., Gulyaeva N.V. Neurophilosophy. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2015. V. 65. N. 4. P. 498-502. DOI: 10.7868/S0044467715040036.
  117. Grigoryan G.A., Gulyaeva N.V. Simulation of animal depression: behavior as basis for methodology, estimation crtiteria and classification. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2015. V. 55. N. 6. P. 643-660.
  118. Druzhkova T.A., Pochigaeva K.I., Gekht A.B., Gulyaeva N.V. Estimate of free cortizole in saliva: relationship with cortizole in blood serum in patients with depressive disorders. Nejrokhimija. 2015. V. 32. N. 4. P. 334-338. DOI: 10.17116/jnevro2016116111.
  119. Ivanova-Dyatlova A.Y., Aniol V.A., Gulyaeva N.V. Ultra-low doses of tetrahydrocannabinol contribute to the survival of newly-born cells in the dentate gyrus of adult rats. Nejrokhimija. 2015. V. 32. N. 3. P. 265-270.
  120. Komoltsev I.G., Levshyna I.P., Novikova M.R., Stepanichev M.Y., Tishkina A.O., Gulyaeva N.V. Changes in brain cortex after dozing head inhury in rats with different age. Morphologija. 2015. V. 148. N. 5. P. 14-20.
  121. Kudryashova I.V. Neurodegenerative measurements under depression: exotoxicity or deficit of trophic factors?. Nejrokhimija. 2015. V. 32. N. 1. .5-12.
  122. Kudryashova I.V. Application of Paired-Pulse Stimulation for the Measurement of Inhibitory Transmission from the Hippocampal CA1 Field Potentials. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2015. V. 65. N. 2. P. 131-138.
  123. Kudryashova I.V. Plasticity of inhibitory synapses as factor of long-term modifications. Najrokhimija. 2015. V. 32. N. 3. P. 181-191.
  124. Loseva E.V., Sarkisova K.Y., Loginova N.A., Kudrin V.S. Depressive behavior and consistency of monoamins in brain structures for rats with chronic boredom. Bulleten Eksperimentalnoj Meditsyny. 2015. V. 159. N. 3. P. 304-308.
  125. Stepanichev M.Y., Tishkina A.O., Lazareva N.A., Martianov E.K., Tukhbatova G.R., Kulagina A.O., Salozhin S.V., Gulyaeva N.V. Expression of TrkA and TrkB neurotrophins high affinity receptors in rat hippocampus after intracerebroventricular administration of βA (25-35). Nejrokhimija. 2015. V. 32. N. 1. P. 57-63.
  126. Shpak A.A., Gekht A.B., Druzhkova T.A., Kozlova K.I., Golovin A.V., Gulyaeva N.V. Ciliary neurotrophic factor in patients with age-related cataract. Nejrokhimija. 2015. V. 32. N. 4. 330–333.
  127. Yakovlev A.A., Gulyaeva N.V. Preconditioning brain cells for pathological effects: the involvement of proteases. Biokhimija. 2015. V. 80. N. 2. P. 204-220.
  128. Aniol V.A., Gulyaeva N.V. Changes in adult neurogenesis in the hippocampus during depressive disorders in humans. Neurochemical Journal. 2015. V. 9. N. 1. P. 8-12. DOI: 10.1134/S181971241501002X.
  129. Druzhkova T.A., Pochigaeva K.I., Guekht A.B., Gulyaeva N.V. Free cortisol assessment in saliva: Saliva-to-serum ratio in depressed patients. Neurochemical Journal. 2015. V. 9. N. 4. P. 315-318. DOI: 10.1134/S1819712415040078.
  130. Dygalo N.N., Stepanichev M.Y., Gulyaeva N.V., Shishkina G.T. Expression of genes in the brain associated with depression. Russian Journal of Genetics: Applied Research. 2015. V. 5. N. 6. P. 582-588. DOI: 10.1134/S2079059715060027.
  131. Fedosova E.A., Sarkisova K.Y., Kudrin V.S., Narkevich V.B., Bazyan A.S. Behavioral and neurochemical characteristics of two months old WAG/Rij rats with genetic absence epilepsy. International Journal of Clinical and Experimental Neurology. 2015. V. 3. N. 2. P. 32-44. DOI: 10.12691/ijcen-3-2-2.
  132. Freiman S.V., Onufriev M.V., Druzhkova T.A., Yakovlev A.A., Pochigaeva K.I., Chepelev A.V., Grishkina M.N., Gudkova A.A., Gekht A.B., Gulyaeva N.V. The change in blood glucose level after a moderate stress as a parameter of stress reactivity in anxiety and depression: A pilot translational study. Neurochemical Journal. 2015. V. 9. N. 2. P. 146-148. DOI: 10.1134/S1819712415020051.
  133. Gulyaeva N.V. Brain ischemia, endoplasmic reticulum stress, and astroglial activation: New insights. Journal of Neurochemistry. 2015. V. 132. N. 3. P. 263-265. DOI: 10.1111/jnc.13016.
  134. Ivanova-Dyatlova A.Y., Aniol V.A., Gulyaeva N.V. Ultra-low doses of tetrahydrocannabinol contribute to the survival of newly-born cells in the dentate gyrus of adult rats. Neurochemical Journal. 2015. V. 9. N. 3. P. 232-236. DOI: 10.1134/S1819712415030046.
  135. Kudryashova I.V. Neurodegenerative changes in depression: Excitotoxicity or a deficit of trophic factors?. Neurochemical Journal. 2015. V. 9. N. 1. P. 1-7. DOI: 10.1134/S1819712415010043.
  136. Kudryashova I.V. The plasticity of inhibitory synapses as a factor of long-term modifications. Neurochemical Journal. 2015. V. 9. N. 3. P. 159-168. DOI: 10.1134/S1819712415030058.
  137. Loseva E.V., Sarkisova K.Y., Loginova N.A., Kudrin V.S. Depressive Behavior and Monoamine Contents in Brain Structures of Rats During Chronic Overcrowding. Bulletin of Experimental Biology and Medicine. 2015. V. 159. N. 3. P. 327-330. DOI: 10.1007/s10517-015-2953-2.
  138. Shpak A.A., Gekht A.B., Druzhkova T.A., Kozlova K.I., Golovina A.V., Gulyaeva N.V. Ciliary neurotrophic factor in patients with age-related cataracts. Neurochemical Journal. 2015. V. 9. N. 4. P. 311-314.
  139. Stepanichev M.Y., Tishkina A.O., Lazareva N.A., Mart'yanova E.K., Tukhbatova G.R., Kulagina A.O., Salozhin S.V., Gulyaeva N.V. The expression of the TrkA and TrkB high-affinity neurotrophin receptors in the rat hippocampus after intracerebroventricular administration of Aβ(25–35). Neurochemical Journal. 2015. V. 9. N. 1. P. 47-53. DOI: 10.1134/S1819712415010110.
  140. Uzakov S.S., Ivanov A.D., Salozhin S.V., Markevich V.A., Gulyaeva N.V. Lentiviral-mediated overexpression of nerve growth factor (NGF) prevents beta-amyloid [25-35]-induced long term potentiation (LTP) decline in the rat hippocampus. Brain Research. 2015. V. 1624. P. 398-404. DOI: 10.1016/j.brainres.2015.07.051.
  141. Yakovlev A.A., Gulyaeva N.V. Possible role of proteases in preconditioning of brain cells to pathological conditions. Biochemistry (Moscow). 2015. V. 80. N. 2. P. 163-171. DOI: 10.1134/S0006297915020030.
  142. Sarkisova K.Y., Kulikov M.A., Kudrin V.S., Midzyanovskaya I.S., Biryukova L.M. Age-related changes in behavior, in monoamines and their metabolites content, and in density of Dl and D2 dopamine receptors in the brain structures of WAG/Rij rats with depression-like pathology. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2014. V. 64. N. 6. P. 668-685. DOI: 10.7868/S0044467714060094.
  143. Peregud D.I., Panchenko L.F., Gulyaeva N.V. Elevation of BDNF Exon I-Specific Transcripts in the Frontal Cortex and Midbrain of Rat During Spontaneous Morphine Withdrawal is Accompanied by Enhanced pCreb1 Occupancy at the Corresponding Promoter. Neurochemical Research. 2014. V. 40. N. 1. P. 130-138. DOI: 10.1007/s11064-014-1476-y.
  144. Stepanichev M., Lazareva N., Tukhbatova G., Salozhin S., Gulyaeva N. Transient disturbances in contextual fear memory induced by Aβ(25-35) in rats are accompanied by cholinergic dysfunction. Behavioural Brain Research. 2014. V. 259. P. 152-157. DOI: 10.1016/j.bbr.2013.11.013.
  145. Stepanichev M.Y., Lazareva N.A., Tukhbatova G.R., Salozhin S., Gulyaeva N.V. Transient disturbances in contextual fear memory induced by Aβ(25-35) in rats are accompanied by cholinergic dysfunction. Behavioural Brain Research. 2014. V. 259. P. 152-157. DOI: 10.1016/j.bbr.2013.11.013.
  146. Lazareva N.A., Kozhukhov S.A., Ivanov R.S., Novikova R.V., Tikhomirov A.S., Tsutskiridze D.I., Bondar I.V. Comparison of its and orientation tuning dynamics in neurons located in different functional domains of cat's primary visual cortex. Zhurnal vyssheǐ nervnoǐ deiatelnosti imeni I P Pavlova. 2013. V. 63. N. 2. P. 205-217. DOI: 10.7868/S0044467713020044.
  147. Sarkisova K.Y., Kulikov M.A., Kudrin V.S., Narkevich V.B., Midzyanovskaya I.S., Biryukova E.V., Folomkina A.A., Bazyan A.S. Neurochemical mechanisms of depression-like behavior in WAG/Rij rats. Zhurnal vyssheǐ nervnoǐ deiatelnosti imeni I P Pavlova. 2013. V. 63. N. 3. P. 303-315. DOI: 10.7868/S0044467713030106.
  148. Aniol V.A., Ivanova-Dyatlova A.Y., Keren O., Guekht A.B., Sarne Y., Gulyaeva N.V. A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats. Epilepsy and Behavior. 2013. V. 26. N. 2. P. 196-202. DOI: 10.1016/j.yebeh.2012.12.006.
  149. Gulyaeva N.V., Stepanichev M.Y. The anti-AD cookbook: A new recipe. Journal of Neurochemistry. 2013. V. 125. N. 1. P. 4-6. DOI: 10.1111/jnc.12138.
  150. Stepanichev M.Yu., Onufriev M.V., Piskunov A.K., Moiseeva Y.V., Lazareva N.A., Moiseenok A.G., Gusev P.V., Gulyaeva N.V. The effects of derivatives of pantothenic acid on free-radical processes and the corticosterone level in the hippocampus and neocortex of rats after interoceptive stress. Neurochemical Journal. 2013. V. 7. N. 2. P. 144-149. DOI: 10.1134/S1819712413020062.
  151. Gulyaeva N.V. Neuroplasticity and epilepsy: modern conceptions and mechanisms of comorhybridity of epilepsy and depression. Zhurnal Nevrologii i Psikhiatrii im S. 2012. V. 52. N. 12. ???. DOI: 10.17116/jnevro2015115112.
  152. Markevich V.A., Sapozhin S.V., Gulyaeva N.V. Involvement of WNT signalling in hippocampal plasticity. Rossijskij Fiziologicheskij Zhurnal im I M Sechenova. 2012. V. 98. N. 12. P. 1460-1470.
  153. Sharova E.V., Malnikov A.V., Novikova M.R., Kulikov M.A., Matz V.N., Shishkina L.V., Ermakov A.M. Functional effects of transcranial electromagnetic stimulation (frequency 60 and 70 Hz) of the brain of rats - intact and with acute stem damage. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2012. V. 62. N. 1. P. 65-78.
  154. Brylev L.V., Zakharova M.N., Zavalishin I.A., Gulyaeva N.V. Disruption of blood-brain barrier in amyotrophic lateral sclerosis: An update. Neurochemical Journal. 2012. V. 6. N. 1. P. 64-70. DOI: 10.1134/S1819712411040064.
  155. Peregud D.I., Yakovlev A.A., Stepanichev M.Y., Onufriev M.V., Panchenko L.F., Gulyaeva N.V. Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence. Bull Exp Biol Med.. 2012. V. 153. N. 6. P. 835-838.
  156. Tishkina A.O., Rukhlenko A., Stepanichev M.Yu., Levshina I., Pasikova N.V., Onufriev M.V., Moiseeva Y.V., Piskunov A., Gulyaeva N.V. Region-specific changes in activities of cell death-related proteases and nitric oxide metabolism in rat brain in a chronic unpredictable stress model. Metabolic Brain Disease. 2012. V. 27. N. 4. P. 431-41. DOI: 10.1007/s11011-012-9328-4.
  157. Aniol V.A., Stepanichev M.Y., Lazareva N.A., Gulyaeva N.V. An early decrease in cell proliferation after pentylenetetrazole-induced seizures. Epilepsy and Behavior. 2011. V. 22. N. 3. P. 433-441. DOI: 10.1016/j.yebeh.2011.08.002.
  158. Sarkisova K.Y., VanLuijtelaar G. The WAG/Rij strain: A genetic animal model of absence epilepsy with comorbidity of depressiony. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2011. V. 35. N. 4. P. 854-876. DOI: 10.1016/j.pnpbp.2010.11.010.
  159. Tukhbatova G.R., Kuleshova E.P., Stepanichev M.Y., Ivanov A.D., Salozhin S.V. Optimization of a preparation of lentiviral particles for transduction of neurons in vivo. Neurochemical Journal. 2011. V. 5. N. 4. P. 294-300. DOI: 10.1134/S1819712411040179.
  160. Yakovlev A.A., Gulyaeva N.V. Pleiotropic functions of brain proteinases: Methodological considerations and search for caspase substrates. Biochemistry (Moscow). 2011. V. 76. N. 10. P. 1079-1086. DOI: 10.1134/S0006297911100014.
  161. Levshyna I.P., Matz V.N., Pasikova N.V., Shuikin N.N. Behavior of rats after immobilization and structural reorganization in the motor cortex and hippocampus. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2010. V. 60. N. 2. P. 184-191.
  162. Sarkisova K.Y., Novikova M.R., Zaichenko M.I., Paramokhin M.L., Gadalin Y.S., Gulyaeva N.V. Remote control of the goal-directed behavior of freely moving rats by telestimulation of the rewarding brain structures. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2010. V. 60. N. 2. P. 236-246.
  163. Antipova T.A., Sapozhnikova D.S., Stepanichev M.Y., Onufriev M.V., Gulyaeva N.V., Seredenin S.B. Effects of selective anxiolytic afobazole on active caspase-3. Bulletin of Experimental Biology and Medicine. 2010. V. 149. N. 2. P. 201-203. DOI: 10.1007/s10517-010-0907-2.
  164. Gulyaeva N.V., Stepanichev M.Y. AΒ(25-35) as proxyholder for amyloidogenic peptides: In vivo evidence. Experimental Neurology. 2010. V. 222. N. 1. P. 6-9. DOI: 10.1016/j.expneurol.2009.12.019.
  165. Gulyaeva N.V., Stepanichev M.Y. AΒ(25-35) as proxyholder for amyloidogenic peptides: In vivo evidence. Experimental Neurology. 2010. V. 222. N. 1. P. 6-9. DOI: 10.1016/j.expneurol.2009.12.019.
  166. Pavlova T.V., Fesenko G.N., Gekht A.B., Gulyaeva N.V., Kovalzon V.M. Convulsive activity in the electroencephalogram in rats sensitive and tolerant to pentylenetetrazol kindling. Neuroscience and Behavioral Physiology. 2010. V. 40. N. 3. P. 239-244. DOI: 10.1007/s11055-010-9249-9.
  167. Pavlova T.V., Stepanichev M.Y., Gekht A.B., Gulyaeva N.V. Acquisition of an active avoidance reaction in rats and morphological changes in the hippocampus in pentylenetetrazol kindling. Neuroscience and Behavioral Physiology. 2010. V. 40. N. 5. P. 501-506. DOI: 10.1007/s11055-010-9288-2.
  168. Sarkisova K.Y., Kuznetsova G.D., Kulikov M.A., VanLuijtelaar G. Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms. Epilepsia. 2010. V. 51. N. 1. P. 146-160. DOI: 10.1111/j.1528-1167.2009.02260.x.
  169. Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Changes in cell proliferation in the subventricular zone of the brain in adult rats given β-amyloid peptide (25-35). Neuroscience and Behavioral Physiology. 2010. V. 40. N. 2. P. 123-126. DOI: 10.1007/s11055-009-9232-5.
  170. Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Changes in cell proliferation in the subventricular zone of the brain in adult rats given β-amyloid peptide (25-35). Neuroscience and Behavioral Physiology. 2010. V. 40. N. 2. P. 123-126. DOI: 10.1007/s11055-009-9232-5.
  171. Brylev L.V. Proteinase inhibitors in the cerebrospinal fluid in neurological diseases. Neurochemical Journal. 2009. V. 3. N. 3. P. 214-220. DOI: 10.1134/S1819712409030106.
  172. Brylev L.V., Nelkina E.N., Yakovlev A.A., Onufriev M.V., Shabalina A.A., Kostyreva M.V., Zakharova M.N., Zavalishin I.A., Gulyaeva N.V. Modulators of cystein proteases and cell-death markers in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Neurochemical Journal. 2009. V. 3. N. 2. P. 133-138. DOI: 10.1134/S1819712409020093.
  173. Kudryashova I.V., Onufriev M.V., Kudryashov I.E., Gulyaeva N.V. Caspase-3 activity in hippocampal slices reflects changes in synaptic plasticity. Neuroscience and Behavioral Physiology. 2009. V. 39. N. 1. P. 13-20. DOI: 10.1007/s11055-008-9089-z.
  174. Kudryashova I.V., Stepanichev M.Y., Gulyaeva N.V. Natural activation of caspase-3 is required for the development of operant behavior in postnatal ontogenesis. Neuroscience and Behavioral Physiology. 2009. V. 39. N. 1. P. 65-72. DOI: 10.1007/s11055-008-9097-z.
  175. Onufriev M.V., Yakovlev A.A., Lyzhin A.A., Stepanichev M.Y., Khaspekov L.G., Gulyaeva N.V. A secreted caspase-3-substrate-cleaving activity at low pH belongs to cathepsin B: A study on primary brain cell cultures. Biochemistry (Moscow). 2009. V. 74. N. 3. P. 281-287. DOI: 10.1134/S0006297909030067.
  176. Tishkina A.O., Levshina I.P., Lazareva N.A., Pasikova N.V., Stepanichev M.Y., Ajrapetyanz M.G., Gulyaeva N.V. Chronic stress induces nonapoptotic neuronal death in the rat hippocampus. Doklady Biological Sciences. 2009. V. 428. N. 1. P. 403-406. DOI: 10.1134/S0012496609050032.
  177. Kudryashova I.V., Onufriev M.V., Kudryashov I.E., Gulyaeva N.V. Caspase-3 activity in hippocampal slices reflects changes in synaptic plasticity. Rossijskij Fiziologicheskij Zhural im I M Sechenova. 2008. V. 94. N. 1. P. 1-14.
  178. Levshyna I.P., Matz V.N., Pasikova N.V., Shuikin N.N. Correlation of the rat behavior after immobilization with structural reorganization in the motor cortex. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2008. V. 58. N. 4. P. 500-506.
  179. Novikova M.R., Sharova E.V., Kulikov M.A., Mats V.N., Shishkina L.V. Study of the role of the right and left orbitofrontal cortex in compensatory cerebral reactions after acute brainstem damag. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2008. V. 58. N. 2. P. 209-216.
  180. Peregud D.I., Vorontsova O.N., Yakovlev A.A., Panchenko L.F., Gulyaeva N.V. Changes in anxiety in abstinence correlate with the state of the nigrostriatal system in the rat hippocampus. Neuroscience and Behavioral Physiology. 2008. V. 38. N. 5. P. 443-448. DOI: 10.1007/s11055-008-9000-y.
  181. Stepanichev M.Y., Onufriev M.V., Yakovlev A.A., Khrenov A.I., Peregud D.I., Vorontsova O.N., Lazareva N.A., Gulyaeva N.V. Amyloid-β (25-35) increases activity of neuronal NO-synthase in rat brain. Neurochemistry International. 2008. V. 52. N. 6. P. 1114-1124. DOI: 10.1016/j.neuint.2007.11.009.
  182. Yakovlev A.A., Gorokhovatsky A.Y., Onufriev M.V., Beletsky I.P., Gulyaeva N.V. Brain cathepsin B cleaves a caspase substrate. Biochemistry (Moscow0. 2008. V. 73. N. 3. P. 332-336.
  183. Brylev L.V., Yakovlev A.A., Onufriev M.V., Zakharova M.N., Zavalishin I.A., Gulyaeva N.V. Calpain-like and lactate dehydrogenase activities in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Neurochemical Journal. 2007. V. 1. N. 4. P. 326-333. DOI: 10.1134/S1819712407040101.
  184. Kudryashov I.E., Pavlova T.V., Kudryashova I.V., Egorova L.K., Gulyaeva N.V. Kindling in the early postnatal period: Effects on the dynamics of age-related changes in electrophysiological characteristics of hippocampal neurons. Neuroscience and Behavioral Physiology. 2007. V. 37. N. 8. P. 765-772. DOI: 10.1007/s11055-007-0080-x.
  185. Sharova E.V., Melnikov A.V., Novikova M.R., Kulikov M.A., Grechenko T.N., Shekhter E.D., Zaslavsky A.Y. Changes in spontaneous brain bioelectrical activity during transcranial electrical and electromagnetic stimulation. Neuroscience and Behavioral Physiology. 2007. V. 37. N. 5. P. 451-457. DOI: 10.1007/s11055-007-0034-3.
  186. Balaban P.M., Gulyaeva N.V. Commonality of molecular mechanisms of neuroplasticity and neuropathology: integrative approach. Rossijskij Fiziologicheskij Zhurnal im I M Sechenova. 2006. V. 92. N. 2. P. 145-152.
  187. Kudryashov I.E., Pavlova T.V., Kudryashova I.V., Egorova L.K., Gulyaeva N.V. Kindling in early postnatal period: impact in dynamics of age changes of electrophysiological characteristics in hippocampal neurons. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2006. V. 56. N. 5. P. 706-714.
  188. Kudryashova I.E., Pigareva M.L., Kudryashova I.V. Prenatal experience and postnatal development in rat's hippocampus: consequences of sleep deprivation. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2006. V. 56. N. 3. P. 401-407.
  189. Sharova E.V., Melnikov A.V., Novikova M.R., Kulikov A.M., Grechenko T.N., Shekhter E.D., Zaslavsky A.Y. Changes in the brain spontaneous bioelectrical activity during transcranial electrical and electromagnetic stimulation. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2006. V. 56. N. 3. P. 363-370.
  190. Bravarenko N.I., Onufriev M.V., Stepanichev M.Y., Ierusalimsky V.N., Balaban P.M., Gulyaeva N.V. Caspase-like activity is essential for long-term synaptic plasticity in the terrestrial snail Helix. European Journal of Neuroscience. 2006. V. 23. N. 1. P. 129-140. DOI: 10.1111/j.1460-9568.2005.04549.x.
  191. Kudryashova I.V., Kudryashov I.E., Gulyaeva N.V. Long-term potentiation in the hippocampus in conditions of inhibition of caspase-3: Analysis of facilitation in paired-pulse stimulation. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 8. P. 817-824. DOI: 10.1007/s11055-006-0092-y.
  192. Pavlova T.V., Yakovlev A.A., Stepanichev M.Y., Gulyaeva N.V. Pentylenetetrazol kindling in rats: Is neurodegeneration associated with manifestations of convulsive activity?. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 7. P. 741-748. DOI: 10.1007/s11055-006-0082-0.
  193. Sarkisova K.Y., Kulikov M.A. Behavioral characteristics of WAG/Rij rats susceptible and non-susceptible to audiogenic seizures. Behavioural Brain Research. 2006. V. 166. N. 1. P. 9-18. DOI: 10.1016/j.bbr.2005.07.024.
  194. Stepanichev M.Y., Zdobnova I., Zarubenko I., Lazareva N.A., Gulyaeva N.V. Differential effects of tumor necrosis factor-alpha co-administered with amyloid beta-peptide (25-35) on memory function and hippocampal damage in rat. Behavioural Brain Research. 2006. V. 175. N. 2. P. 352-361. DOI: 10.1016/j.bbr.2006.09.006.
  195. Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Lazareva N.A., Gulyaeva N.V. Studies of the effects of central administration of β-amyloid peptide (25-35): Pathomorphological changes in the hippocampus and impairment of spatial memory. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 1. P. 101-106. DOI: 10.1007/s11055-005-0167-1.
  196. Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Lazareva N.A., Gulyaeva N.V. Studies of the effects of central administration of β-amyloid peptide (25-35): Pathomorphological changes in the hippocampus and impairment of spatial memory. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 1. P. 101-106. DOI: 10.1007/s11055-005-0167-1.
  197. Levshyna I.P., Pasikova N.V., Shuikin N.N. Avoidance conditioning and morphometric characteristics of the sensorimotor cortex of rats exposed to social deprivation in early ontogeny. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2005. V. 55. N. 4. P. 558-566.
  198. Onufriev M.V., Gulyaeva N.V., Terenina N.B., Tolstenkov O.O., Gustafsson M.K. The effect of a nitric oxide donor on the synthesis of cGMP in Hymenolepis diminuta: A radiometric study. Parasitology Research. 2005. V. 95. N. 1. P. 22-24. DOI: 10.1007/s00436-004-1245-y.
  199. Petrova E.V., Gulyaeva N.V., Titarov S.I., Rozhnov Y.V., Kovalzon V.M. Actions of pulsed ultra-broadband electromagnetic irradiation on the EEG and sleep in laboratory animals. Neuroscience and Behavioral Physiology. 2005. V. 35. N. 2. P. 165-170.
  200. Samarova E.I., Bravarenko N.I., Korshunova T.A., Gulyaeva N.V., Palotas A., Balaban P.M. Effect of β-amyloid peptide on behavior and synaptic plasticity in terrestrial snail. Brain Research Bulletin. 2005. V. 67. N. 1-2. P. 40-45. DOI: 10.1016/j.brainresbull.2005.05.023.
  201. Samarova E.I., Bravarenko N.I., Korshunova T.A., Gulyaeva N.V., Palotas A., Balaban P.M. Effect of β-amyloid peptide on behavior and synaptic plasticity in terrestrial snail. Brain Research Bulletin. 2005. V. 67. N. 1-2. P. 40-45. DOI: 10.1016/j.brainresbull.2005.05.023.
  202. Samarova E.I., Bravarenko N.I., Korshunova T.A., Gulyaeva N.V., Palotas A., Balaban P.M. Effect of β-amyloid peptide on behavior and synaptic plasticity in terrestrial snail. Brain Research Bulletin. 2005. V. 67. N. 1-2. P. 40-45. DOI: 10.1016/j.brainresbull.2005.05.023.
  203. Stepanichev M.Y., Kudryashova I.V., Yakovlev A.A., Onufriev M.V., Khaspekov L.G., Lyzhin A.A., Lazareva N.A., Gulyaeva N.V. Central administration of a caspase inhibitor impairs shuttle-box performance in rats. Neuroscience. 2005. V. 136. N. 2. P. 579-591. DOI: 10.1016/j.neuroscience.2005.08.010.
  204. Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Gulyaeva N.V. Studies of the effects of fragment (25-35) of beta-amyloid peptide on the behavior of rats in a radial maze. Neuroscience and Behavioral Physiology. 2005. V. 35. N. 5. P. 511-518. DOI: 10.1007/s11055-005-0086-1.
  205. Zarubenko I.I., Yakovlev A.A., Stepanichev M.Y., Gulyaeva N.V. Electroconvulsive shock induces neuron death in the mouse hippocampus: Correlation of neurodegeneration with convulsive activity. Neuroscience and Behavioral Physiology. 2005. V. 35. N. 7. P. 715-721. DOI: 10.1007/s11055-005-0115-0.
  206. Melnikov A.V., Kulikov M.A., Novikova M.R., Sharova E.V. Selection of behavioral test parameters for estimation of typological features of rat behavio. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2004. V. 54. N. 5. P. 712-717.
  207. Kudryashov I.E., Yakovlev A.A., Kudryashova I.V., Gulyaeva N.V. Inhibition of caspase-3 blocks long-term potentiation in hippocampal slices. Neuroscience and Behavioral Physiology. 2004. V. 34. N. 9. P. 877-880. DOI: 10.1023/B:NEAB.0000042571.86110.28.
  208. Pavlova T.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritskii A.M., Gulyaeva N.V. Pentylenetetrazole kindling induces activation of caspase-3 in the rat brain. Neuroscience and Behavioral Physiology. 2004. V. 34. N. 1. P. 45-47. DOI: 10.1023/B:NEAB.0000003246.26997.10.
  209. Semenova T.P., Onufriev M.V., Anoshkina I.A., Moiseeva Y.V., Kolaeva S.G., Gulyaeva N.V., Fesenko E.E. The roles of monoamine oxidase form A (MAO A) and NO synthase in the mechanisms of the emergence from hibernation in the ground squirrel Citellus undulatus. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from. 2004. V. 398. P. 403-405. DOI: 10.1023/B:DOBS.0000046668.36196.b7.
  210. Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Amyloid-β(25-35)-induced memory impairments correlate with cell loss in rat hippocampus. Physiology and Behavior. 2004. V. 80. N. 5. P. 647-655. DOI: 10.1016/j.physbeh.2003.11.003.
  211. Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Amyloid-β(25-35)-induced memory impairments correlate with cell loss in rat hippocampus. Physiology and Behavior. 2004. V. 80. N. 5. P. 647-655. DOI: 10.1016/j.physbeh.2003.11.003.
  212. Vederko O.V., Danilova N.N., Kogan B.M., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. The effects of information stress in humans: the ratio of biochemical parameters and heart rate. Nejrokhimija. 2003. V. 20. P. 91-97.
  213. Gulyaeva N.V. Non-apoptotic functions of caspase 3 in nerve tissue. Biokhimija. 2003. V. 68. P. 1459-1470.
  214. Kudryashov I.E., Yakovlev A.A., Kudryashova I.V., Gulyaeva N.V. Caspase-3 inhibition blocks prolonged potentiation in hippocampal slices. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2003. V. 53. P. 537-540.
  215. Moshnikova A.B., Onufriev M.V., Afanasiev V.N., Zhukova A.A., Gulyaeva N.V., Beletsky A.P. Analysis of nuclease sequences in dying and differentiating U-937 cells. Molekuliarnaja Meditsina. 2003. V. 1. P. 52-58.
  216. Onufriev M.V., Titarov S.I., Tkachenko B.K., Gulyaeva N.V. The effect of ultra-wideband electromagnetic radiation on nitric oxide synthase activity in rat brain. Nejrokhimija. 2003. V. 20. P. 88-90.
  217. Pavlova I.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritsky A.M., Gulyaeva N.V. Pentylenetetrazole kindling induces activation of caspase-3 in the rat brain. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2003. V. 53. P. 110-113.
  218. Panchenko L.F., Peregud D.I., Pirozhkov S.V., Onufriev M.V., Gulyaeva N.V. The effect of morphine on the content of nitric oxide metabolites in the brain regions of inbred rats of the WAG / Gsto and Fischer-344 / N lines. Narkologija. 2003. V. 1. N. 4. P. 28-30.
  219. Petrova E.V., Gulyaeva N.V., Titarov S.I., Rozhnov Y.V., Kovalzon V.M. The effect of pulsed ultra-wideband electromagnetic radiation on the electroencephalogram and sleep of laboratory animals. Rossijskoj Fiziologicheskij Zhurnal im I M Sechenova. 2003. V. 89. P. 786-794.
  220. Solnyshkova T.G., Gulyaeva N.V., Shakhlamov V.A. Structural and biochemical changes in some parts of the brain when exposed to natural hydrogen sulfide-containing gas. Correction prospects. Nejrokhimija. 2003. V. 20. P. 228-232.
  221. Khaspekov L.G., Onufriev M.V., Lyzhin A.A., Viktorov I.V., Gulyaeva N.V. The effect of ischemia and reoxygenation on the release of nitrites from organotypic rat brain explants. Nejrokhimija. 2003. V. 20. P. 60-64.
  222. Sharova E.V., Novikova M.R., Kulikov M.A., Shishkina L.V., Sidorov B.M., Melnikov A.B. Rat brain reactions to acute brain stem lesion on dynamics of parameters of cerebral electric activity. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2003. V. 53. N. 2. P. 228-239.
  223. Yakovlev A.A., Peregud D.I., Egorova L.K., Panchenko L.F., Gulyaeva N.V. Caspase-3 activity in the brain regions of rats of Fischer-344 / N and WAG / G rats. Nejrokhimija. 2003. V. 20. P. 265-268.
  224. Egorova L.K., Stepanichev M.Y., Mikhalev S.L., Kutepova O.A., Gulyaeva N.V. Analysis of cyclic adenosine-3′,5′-monophosphate levels in structures of the "Informational" and "Motivational" systems of the rat brain during acquistion of a conditioned active avoidance reaction. Neuroscience and Behavioral Physiology. 2003. V. 33. N. 4. P. 329-333. DOI: 10.1023/A:1022887321863.
  225. Gulyaeva N.V. Non-apoptotic functions of caspase-3 in nervous tissue. Biochemistry (Moscow). 2003. V. 68. N. 11. P. 1171-1180. DOI: 10.1023/B:BIRY.0000009130.62944.35.
  226. Gulyaeva N.V., Kudryashov I.E., Kudryashova I.V. Caspase activity is essential for long-term potentiation. Journal of Neuroscience Research. 2003. V. 73. N. 6. P. 853-864. DOI: 10.1002/jnr.10730.
  227. Gulyaeva N.V., Kudryashov I.E., Kudryashova I.V. Caspase activity is essential for long-term potentiation. Journal of Neuroscience Research. 2003. V. 73. P. 853-864.
  228. Gulyaeva N.V., Thompson C., Shinohara N., Lazareva N.A., Onufriev M.V., Stepanichev M.Y., Moiseeva Y.V., Fliss H., Hakim A.M. Tongue protrusion: A simple test for neurological recovery in rats following focal cerebral ischemia. Journal of Neuroscience Methods. 2003. V. 125. N. 1-2. P. 183-193. DOI: 10.1016/S0165-0270(03)00056-6.
  229. Sarkisova K.Y., Midzyanovskaya I.S., Kulikov M.A. Depression-like behavioral alterations and c-fos expression in the dopaminergic brain regions in WAG/Rij rats with genetic absence epilepsy. Behavior and Brain Research. 2003. V. 144. N. 1-2. P. 211-226. DOI: 10.1016/S0166-4328(03)00090.
  230. Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Single intracerebroventricular administration of amyloid-beta (25-35) peptide induces impairment in short-term rather than long-term memory in rats. Brain Research Bulletin. 2003. V. 61. N. 2. P. 197-205. DOI: 10.1016/S0361-9230(03)00118-7.
  231. Stepanichev M.Y., Zdobnova I.M., Yakovlev A.A., Onufriev M.V., Lazareva N.A., Zarubenko I.I., Gulyaeva N.V. Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35). Journal of Neuroscience Research. 2003. V. 71. N. 1. P. 110-120. DOI: 10.1002/jnr.10469.
  232. Terenina N.B., Onufriev M.V., Gulyaeva N.V., Moiseeva Y.V., Gustafsson M.K. Nitric oxide synthase activity in Fasciola hepatica: a radiometric study. Parasitology. 2003. V. 126. N. 6. P. 585-590.
  233. Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Administration of aggregated beta-amyloid peptide (25-35) induces changes in long-term potentiation in the hippocampus in vivo. Neuroscience and behavioral physiology. 2003. V. 33. N. 2. P. 95-98. DOI: 10.1023/A:1021761310435.
  234. Adiatullin A.I., Gulyaeva N.V. The influence of the natural biocorrector Namivite on free radical processes in abdominal delivery. Bulleten Esperimentalnoj biologii i meditsiny. 2002. V. 134. P. 532-534.
  235. Egorova L.K., Stepanichev M.Y., Mikhalev S.L., Kutepova O.A., Gulyaeva N.V. Analysis of cyclic adenosine-3',5'-monophosphate levels in structures of the "informational" and "motivational" systems of the rat brain during acquisition of a conditioned active avoidance reaction. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2002. V. 52. P. 235-240.
  236. Zdobnova I.M., Stepanichev M.Y., Yakovlev A.A., Onufriev M.V., Egorova L.K., Moiseeva Y.V., Lazareva N.A., Matz V.N., Gulyaeva N.V. The interaction of the neurotoxic fragment of the beta-amyloid peptide and tumor necrosis factor alpha with intracerebral administration to rats. Nejrokhimija. 2002. V. 19. P. 117-122.
  237. Onufriev M.V., Semenova T.P., Kopaeva S.G., Moiseeva Y.V., Egorova L.K., Gulyaeva N.V. Nitric oxide synthase activity in the brain regions of Citellus undulatus gophers in different phases of the hibernation cycle. Nejrokhimija. 2002. V. 19. P. 264-268.
  238. Pavlova I.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritsky A.M., Gulyaeva N.V. Pentylenetetrazole Kindling causes oxidative stress in rat brain. Nejrokhimija. 2002. V. 19. P. 123-126.
  239. Reutov V.P., Kuzenkov V.S., Krushinskij A.P., Koshelev V.B., Ryasina T.B., Levshyna I.P., Shujkin N.N., Kositsyn N.S., Ajrapetiantz M.G. Development of stress injuries in rats of the Krushinsky-Molodkina lineage, genetically predisposed to seizures, under the influence of a NO-generating compound and a blocker of NO synthase. Vesti Natsionalnij Akademii Nauk Belarusi. Serija Mediko-Biologicheskikh Nauk. 2002. V. 1. N. 1. P. 5-10.
  240. Sarkisova K.Y., Midzyanovskaya I.S., Kulikov M.A. Depression-like change in behaviour and expression of c-fos gene in dopaminergic brain structures in Wag/Rij rats. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2002. V. 52. N. 6. P. 733-742.
  241. Stepanichev M.Y., Moiseeva Y.V., Gulyaeva N.V. "Injection" models of Alzheimer's disease: oxidative stress in the toxicity mechanism of AF64A and β-amyloid peptide in rodents. Nejrokhimija. 2002. V. 19. P. 165-175.
  242. Khaspekov L.G., Onufriev M.V., Lyzhin A.A., Viktorov I.V., Gulyaeva N.V. The dynamics of proteolytic activity associated with caspase-3, with ischemic effects on cultured rat cerebellum grain cells. Nejrokhimija. 2002. V. 19. P. 37-40.
  243. Yakovlev A.A., Semenova T.P., Kolaeva S.G., Onufriev M.V., Mikhalea S.L., Gulyaeva N.V. Change in caspase-3 activity in the brain regions of gophers of Citellus undulatus during the hibernation cycle. Nejrokhimija. 2002. V. 19. 33-36.
  244. Adiyatulin A.I., Gulyaeva N.V. Effect of natural biocorrector namivit on free-radical processes in abdominal delivery. Bulletin of Experimental Biology and Medicine. 2002. V. 134. N. 5. P. 457-459. DOI: 10.1023/A:1022690330562.
  245. Kudryashov I.E., Yakovlev A.A., Kudryashova I.V., Gulyaeva N.V. Footshock stress alters early postnatal development of electrophysiological responses and caspase-3 activity in rat hippocampus. Neuroscience Letters. 2002. V. 332. N. 2. P. 95-98. DOI: 10.1016/S0304-3940(02)00937-0.
  246. Bolshakov A.P., Onufriev M.V., Khanicheva N.A., Stepanichev M.Y., Chabak-Garbach R.., Ajrapetiantz M.G., Gulyaeva N.V. Effect of early social isolation on nitric oxide synthase activity in rat brain. Nejrokhimija. 2001. V. 18. P. 262-266.
  247. Moiseeva Y.V., Onufriev M.V., Lazareva N.A., Stepanichev M.Y., Gulyaeva N.V. Free-radical mechanisms of septo-hippocampal neurodegeneration caused by cholinotoxin AF64A in rats in vivo. Nejrokhimija. 2001. V. 18. P. 287-289.
  248. Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Administration of aggregated beta-amyloid peptide (25-35) causes change in long-term potentiation in the hippocampus. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2001. V. 51. N. 6. P. 690-693.
  249. Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Increase in activity of NO-synthetase in rat's hippocampus follows long-term potentiation in vivo. Nejrokhimiya. 2001. V. 18. N. 1. P. 55-61.
  250. Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Administration of aggregated beta-amyloid peptide (25-35) induces changes in long-term potentiation in hippocampus in vivo. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2001. V. 51. N. 6. P. 701-704.
  251. Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Increased NO synthase activity in rat hippocampus accompanies prolonged in vivo potentiation. Nejrokhimija. 2001. V. 18. P. 55-61.
  252. Tsubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Administration of aggregated beta-amyloid peptide (25–35) induces changes in long-term potentiation in the hippocampus in vivo. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2001. V. 51. P. 701-704.
  253. Yakovlev A.A., Onufriev M.V., Stepanichev M.Y., Braun K.., Gulyaeva N.V. Caspase-3 activity in different parts of the brain of rodents. Nejrokhimija. 2001. V. 18. P. 41-43.
  254. Yakovlev A.A., Onufriev M.V., Stepanichev M.Y., Gulyaeva N.V. The effect of pentylenetetrazole on caspase-3 activity in the brain regions of mice. Nejrokhimija. 2001. V. 18. P. 191-194.
  255. Kudryashov I.E., Onufriev M.V., Kudryashova I.V., Gulyaeva N.V. Periods of postnatal maturation of hippocampus: Synaptic modifications and neuronal disconnection. Developmental Brain Research. 2001. V. 132. N. 2. P. 113-120. DOI: 10.1016/S0165-3806(01)00301-7.
  256. Melnik V.I., Bikbulatova L.S., Gulyaeva N.V., Bazyan A.S. Synaptic vesicle acidification and exocytosis studied with acridine orange fluorescence in rat brain synaptosomes. Neurochemical Research. 2001. V. 26. N. 5. P. 549-554. DOI: 10.1023/A:1010973214930.
  257. Bikbulatova L.S., Melnik V.I., Gulyaeva N.V., Bazyan A.S. Acridinorange as a fluorescent probe for the study of acidification and exocytosis of synaptic vesicles in synaptosomes. Nejrokhimija. 2000. V. 17. P. 303-308.
  258. Novikova M.R., Sharova E.V., Mikheeva T.S., Shishkina L.V., Kulikov M.A. The effects of combined electrolytic brain stem-orbitofrontal and brain stem-hippocampal damages to the rat brain. Patologicheskaya Fiziologiya i Eksperimentalnaya Terapiya. 2000. V. 1. N. 3. P. 5-9.
  259. Sarkisova K.Y., Kulikov M.A. Profilactic effect of antioxidant AEKOL on behavioral (psychoemotional) disturbances caused by chronic stress in rats. Rossijskij Fiziologicheskij Zhurnal im I M Sechenova. 2000. V. 86. N. 5. P. 557-564.
  260. Sarkisova K.Y., Kulikov M.A. Wag/Rij rats: new genetically determined model of animal depression?. Doklady Academii Nauk. 2000. V. 374. N. 6. P. 732-775.
  261. Khaspekov L.G., Onufriev M.V., Viktorov I.V., Gulyaeva N.V. The effect of ischemia and reoxygenation on the accumulation of nitrites in rat cerebellum grain cell cultures. Nejrokhimija. 2000. V. 17. P. 267-270.
  262. Sharova E.V., Novikova M.R., Mikheeva T.S., Shishkina L.V., Kulikov M.A. The effects of combined electrolytic stem-orbitofrontal and stem-hippocampal damage to rat brain. Patologicheskaja Fiziologija i Eksperimentalnaja Terapija. 2000. V. ??. N. 3. P. 5-9.
  263. Bobrysheva I.V., Chernyavskaya L.I., Onufriev M.V., Grivennikov I.A., Gulyaeva N.V. Hydrogen peroxide dose-dependently inhibits caspase-3 in PC12 cells. Nejrokhimija. 2000. V. 17. P. 93-98.
  264. Lautenschlager M., Onufriev M.V., Gulyaeva N.V., Harms C., Freyer D., Sehmsdorf U.-., Ruscher K., Moiseeva Y.V., Arnswald A., Victorov I., Dirnagl U., Weber J.R., Hortnagl H. Role of nitric oxide in the ethylcholine aziridinium model of delayed apoptotic neurodegeneration in vivo and in vitro. Neuroscience. 2000. V. 97. N. 2. P. 383-393. DOI: 10.1016/S0306-4522(99)00599-0.
  265. Lautenschlager M., Onufriev M.V., Gulyaeva N.V., Harms C., Freyer D., Sehmsdorf U.-., Ruscher K., Moiseeva Y.V., Arnswald A., Victorov I., Dirnagl U., Weber J.R., Hortnagl H. Role of nitric oxide in the ethylcholine aziridinium model of delayed apoptotic neurodegeneration in vivo and in vitro. Neuroscience. 2000. V. 97. N. 2. P. 383-393. DOI: 10.1016/S0306-4522(99)00599-0.
  266. Onufriev M.V., Terenina N.B., Lindholm A.M., Reuter M., Gustafsson M.K., Gulyaeva N.V. Neuronal form of nitric oxide synthase activity in Hymenolepis diminuta (Cestoda: Pseudophyllidae). Nejrokhimija. 2000. V. 17. P. 37-41.
  267. Poeggel G., Haase C., Gulyaeva N.V., Braun K. Quantitative changes in reduced nicotinamide adenine dinucleotide phosphate-diaphorase-reactive neurons in the brain of Octodon degus after periodic maternal separation and early social isolation. Neuroscience. 2000. V. 99. N. 2. P. 381-387. DOI: 10.1016/S0306-4522(00)00190-1.
  268. Stepanichev M.Y., Onufriev M.V., Bock J., Gulyaeva N.V., Poeggel G., Braun K. Changes of nitric oxide synthase activity in response to different levels of social separation in two day old domestic chicks (Gallus gallus domesticus). Neuroscience Research Communications. 2000. V. 27. P. 175-181.
  269. Stepanichev M.Y., Onufriev M.V., Mitrokhina O.S., Moiseeva Y.V., Lazareva N.A., Victorov I.V., Gulyaeva N.V. Neurochemical, behavioral, and neuromorphological effects of central administration of beta-amyloid peptide (25-35) in rat. Nejrokhimija. 2000. V. 17. P. 278-290.
  270. Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Lazareva N.A., Onufriev M.V., Moiseeva Y.V., Chernyavskaya L.I., Gulyaeva N.V. Seizure intensity correlates with oxidative stress and apoptosis in the hippocampus in the kainic acid model in rat. Nejrokhimija. 2000. V. 17. P. 189-191.
  271. Terenina N.B., Onufriev M.V., Gulyaeva N.V., Lindholm A.M., Gustafsson M.K. A radiometric analysis of nitric oxide synthase activity in Hymenolepis diminuta. Parasitology. 2000. V. 120. N. 1. P. 91-95. DOI: 10.1017/S0031182099005284.
  272. Gulyaeva N.V., Brusovanik V.I., Lazareva N.A., Libe M.L., Mikhalev S.L., Onufriev M.V., Chernyavskaja L.I. Indices of free radical oxidation in plasma of umbilical cord blood and placenta of residents of Altai Territory. Izvestija Academii nauk, serija biologicheskaja. 1999. V. 1. N. 4. P. 453-457.
  273. Kudryashova I.E., Kudryashova I.V., Sitnikova E.Y., Raevsky V.V. The effect of forelimb deafferentation in early postnatal ontogeny on the development of synaptic transmission in the hippocampus. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1999. V. 49. N. 4. P. 554-565.
  274. Kudryashov I.E., Kudryashova I.V., Sitnikova E.Y., Raevsky V.V. The influence of deafferentation of the forelimb in early postnatal ontogenesis on the formation of synaptic transmission in the hippocampus. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1999. V. 49. N. 4. P. 629-634.
  275. Mitrokhina O.S., Stepanichev M.Y., Lazareva N.A., Moiseeva Y.V., Onufriev M.V., Gulyaeva N.V. The effect of intracerebroventricular administration of a fragment (25-35) of beta-amyloid peptide on lipid peroxidation in rat brain and blood. Doklady Akademii Nauk. 1999. V. 368. P. 711-713.
  276. Moiseeva Y.V., Egorova L.K., Onufriev M.V., Mitrokhina O.S., Lazareva N.A., Stepanichev M.Y., Gulyaeva N.V. NO synthase activity and indicators of free radical oxidation in the brain regions of Wistar rats resistant and prone to audiogenic epilepsy: effects of immobilization stress. Nejrokhimija. 1999. V. 16. P. 54-61.
  277. Onufriev M.V., Stepanichev M.Y., Mitrokhina O.S., Moiseeva Y.V., Lazareva N.A., Gulyaeva N.V. The effect of oxidative stress on the activity of nitric oxide synthase in vivo and in vitro. Rossijskoj Fiziologicheskij Zhurnal. 1999. V. 85. P. 531-538.
  278. Rozhnova U.A., Stepanichev M.Y., Korobko V.G., Gulyaeva N.V., Alesenko A.V. Activation of the sphingomoelin cycle and cholesterol accumulation in rat cortex, hippocampus and cerebellum under the action of tumor necrosis factor alpha. Nejrokhimija. 1999. V. 16. 118-131.
  279. Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Zarzhetsky Y.V., Mutuskina E.A., Gurvich A.M., Gulyaeva N.V. Delayed effects of systemic circulatory arrest on free radical processes in the brain structures of rats with different types of behavior in the emotional resonance test. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1999. V. 49. P. 653-663.
  280. Poeggel G., Lange E., Hase C., Metzger M., Gulyaeva N.V., Braun K. Maternal separation and early social deprivation in octodon degus: Quantitative changes of nicotinamide adenine dinucleotide phosphate-diaphorase-reactive neurons in the prefrontal cortex and nucleus accumbens. Neuroscience. 1999. V. 94. N. 2. P. 497-504. DOI: 10.1016/S0306-4522(99)00289-4.
  281. Rakusan K., Ehrenburg I.V., Gulyaeva N.V., Tkatchouk E.N. The effect of intermittent normobaric hypoxia on vascularization of human myometrium. Microvascular Research. 1999. V. 58. N. 2. P. 200-203. DOI: 10.1006/mvre.1999.2180.
  282. Silkis I.G., Egorova L.K., Markevich V.A., Gulyaeva N.V. On the participation of GABAb receptors in the formation of cGMP in the cerebellar cortex. Nejrokhimija. 1998. V. 15. N. 4. P. 335-400.
  283. Kudryashov I.E., Kudryashova I.V., Raevsky V.V. Ribonuclease improves the state of hippocampal sections in the post-ischemic period. Neuroscience and Behavioral Physiology. 1998. V. 28. N. 4. P. 357-365. DOI: 10.1007/BF02464788.
  284. Stepanichev M.Y., Lazareva N.A., Onufriev M.V., Mitrokhina O.S., Moiseeva Y.V., Gulyaeva N.V. Effects of doses of fragment (25-35) of β-amyloid peptide on behavior in rats. Neuroscience and Behavioral Physiology. 1998. V. 28. N. 5. P. 564-566. DOI: 10.1007/BF02463018.
  285. Kudryashov I.E., Kudryashova I.V., Raevsky V.V. Ribonuclease improves the function of hippocampal slices in the postischemic period. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1997. V. 47. N. 1. P. 136-146.
  286. Raevsky V.V., Alexandrov L.I., Vorobieva A.D., Korneeva E.V., Kudryashov I.E., Kudryashova I.V., Pigareva M.L., Sitnikova E.Y., Stashkevich I.S. Sensory information is an important factor in ontogenesis. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1997. V. 47. N. 2. P. 299-307.
  287. Gulyaeva N.V., Stepanichev M.Y. Biochemical correlates of individual behavior. Neuroscience and Behavioral Physiology. 1997. V. 27. N. 4. P. 462-469. DOI: 10.1007/BF02462948.
  288. Gurvitch A.M., Mutuskina E.A., Zarzhetsky Y.V., Trubina I.E., Avruschenko M.S., Pylova S.I., Volkov A.V., Lazareva N.A., Stepanichev M.Y., Onufriev M.V., Gulyaeva N.V. Prophylaxis of encephalopathies and risk factors of atherogenesis development in the postresuscitation period in rats by means of succinic acid. Resuscitation. 1997. V. 35. N. 2. P. 165-170. DOI: 10.1016/S0300-9572(97)00045-2.
  289. Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Zazhetsky Y.V., Mutuskina E.A., Gutvitch A.M., Gulyaeva N.V. Postresuscitation changes in brain free radical-mediated processes and nitric oxide synthase activity in rats: effects of individual behavior in "emotional resonance" test. Neurochemical Research. 1997. V. 22. N. 6. P. 743-752.
  290. Sharova E.V., Novikova M.R., Mikheeva G.S., Shishkina L.V., Lushchekina E.A. Local destruction of Deiters' lateral vestibular nucleus (an experimental model of a focal brain stem lesion). Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1996. V. 46. N. 3. P. 583-591.
  291. Gulyaeva N.V., Lazareva N.A., Libe M.L., Mitrokhina O.S., Onufriev M.V., Stepanichev M.Y., Chernysevskaya I.A., Walsh T.J. Oxidative stress in the brain following intraventricular administration of ethylcholine aziridinium (AF64A). Brain Research. 1996. V. 726. N. 1-2. P. 174-180. DOI: 10.1016/0006-8993(96)00330-7.
  292. Gulyaeva N.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Zarzhetsky Y.V., Gurvitch A.M., Volkov A.V. Cardiac arrest induces decrease of nitric oxide synthase activity and increase of free radical generation in rat brain regions. Neuroscience Letters. 1996. V. 220. N. 3. P. 147-150. DOI: 10.1016/S0304-3940(96)13250-X.
  293. Balaban P.M., Bravarenko N.I., Voronin L.L., Gusev P.V. Long-term potentiation in the helix central nervous system after intracellular tetanization. Doklady Academii Nauk. 1995. V. 343. N. 4. P. 563-566.
  294. Bravarenko N.I., Gusev P.V., Balaban P.M., Voronin L.L. Postsynaptic induction of long-term synaptic facilitation in snail central neurons. NeuroReport. 1995. V. 6. N. 8. P. 1182-1186. DOI: 10.1097/00001756-199505300-00027.
  295. Gulyaeva N.V., Onufriev M.V., Stepanichev M.Y. No synthase and free radical generation in brain regions of old rats: Correlations with individual behaviour. NeuroReport. 1994. V. 6. N. 1. P. 94-96. DOI: 10.1097/00001756-199412300-00025.
 

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