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Karine Y. Sarkisova

D.Sc. in Biology, Leading Scientist

absence epilepsy, comorbid depression, experimental model, WAG/Rij rats, neurochemical and epigenetic mechanisms

Laboratory of Functional Biochemistry of the Nervous System

Scopus ID
57193508841
ORCID ID
0000-0003-2914-8036
Web of Science ResearcherID
AAO-1640-2020
SPIN code
6458-8978

Publication list

  1. Sarkisova K.Y., Fedosova E.A., Shatskova A.B., Rudenok M.M., Stanishevskaya V.A., Slominsky P.A. Maternal Methyl-Enriched diet increases DNMT1, HCN1, and TH Gene Expression and Suppresses Absence Seizures and Comorbid Depression in Offspring of WAG/Rij Rats. Diagnostics. 2023. V. 13. N. 398. P. 1-17. DOI: 10.3390/diagnostics13030398.
  2. Fedosova E.A., Shatskova A.B., Sarkisova K.Yu. Ethosuximide improves cognitive flexibility during reversal learning in WAG/Rij rats with absence epilepsy and comorbid depression. J. Evol. Biochem. Physiol.. 2022. V. 58. N. 1. P. 98-116. DOI: 10.1134/S0022093022010100.
  3. Sarkisova K.Y., Fedosova E.A., Shatskova A.B., Narkevich V.B., Kudrin V.S. Maternal Methyl-Enriched Diet Increases Dopaminergic Tone of the Mesolimbic Brain System in Adult Offspring of WAG/Rij Rats. Doklady Biological Sciences. 2022. V. 506. N. 1. P. 145-149. DOI: 10.1134/S001249662205012X.
  4. Sarkisova K.Y., van Luijtelaar G. The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities. IBRO Neuroscience Reports. 2022. V. 13. P. 436-468. DOI: 10.1016/j.ibneur.2022.10.012.
  5. Sushkova O.S., Morozov A.A., Petrova N.G., Khokhlova M.N., Gabova A.V., Karabanov A.V., Chigaleychik L.A., Sarkisova K.Y. Method of wave train electrical activity analysis - the theoretical basis and application. Radioelektronika, Nanosistemy, Informacionnye Tehnologii. 2022. V. 14. N. 3. P. 317-330. DOI: 10.17725/rensit.2022.14.317.
  6. Fedosova E.A., Shatskova A.B., Sarkisova K.Yu. Ethosuximide Increases Exploratory Motivation and Improves Episodic Memory in the Novel Object Recognition Test in WAG/Rij Rats with Genetic Absence Epilepsy. Neuroscience and Behavioral Physiology. 2021. V. 51. N. 4. P. 501-512. DOI: 10.1007/s11055-021-01097-z.
  7. Sarkisova K.Y., Gabova A.V., Fedosova E.A., Shatskova A.B. Gender-Dependent Effect of Maternal Methyl-Enriched Diet on the Expression of Genetic Absence Epilepsy and Comorbid Depression in Adult Offspring of WAG/Rij Rats. Doklady Biological Sciences. 2020. V. 494. N. 1. P. 244-247. DOI: 10.1134/S0012496620050075.
  8. Leo A., Citraro R., Tallarico M., Iannone M., Fedosova E.A., Nesci V., de Sarro G., Sarkisova K.Y., Russo E. Cognitive impairment in the WAG/Rij rat absence model is secondary to absence seizures and depressive-like behavior. Progress in Neuropsychopharmacology & Biological Psychiatry. 2019. V. 94. N. 109652. DOI: 10.1016/j.pnpbp.2019.109652.
  9. Gabova A.V., Sarkisova K.Y., Fedosova E.A., Shatskova A.B., Morozov A.A. Age-related changes of spike-wave discharges in WAG/Rij rats with genetic absence epilepsy. Russian Journal of Physiology. 2018. V. 104. N. 10. P. 1176-1189. DOI: 10.7868/S0869813918100052.
  10. Loseva E.V., Loginova N.A., Sarkisova K.Y., Klodt P.M., Narkevich V.B., Kudrin V.S. Behavioral Symptoms of Anxiety and Depression and Brain Monoamine Contents in Rats after Chronic Intranasal Administration of Interferon-α. Neuroscience and Behavioral Physiology. 2018. V. 48. N. 8. P. 954-962. DOI: 10.1007/s11055-018-0655-8.
  11. Mazarati A., Jones N.C., Galanopoulou A.S., Harte-Hargrove L.C., Kalynchuk L.E., Lenck-Santini P.-., Medel-Matus J.-., Nehlig A., DeLaPrida L.M., Sarkisova K.Y., Veliskova J. A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force. Epilepsia Open. 2018. V. 3. P. 24-52. DOI: 10.1002/epi4.12236.
  12. Sarkisova K.Y., Gabova A.V. Maternal care exerts disease-modifying effects on genetic absence epilepsy and comorbid depression. Genes, Brain and Behavior. 2018. V. 17. N. 7. e12477. DOI: 10.1111/gbb.12477.
  13. Sarkisova K.Y., Fedotova I.B., Surina N.M., Nikolaev G.M., Perepelkina O.V., Kostina Z.A., Poletaeva I.I. Genetic background contributes to the co-morbidity of anxiety and depression with audiogenic seizure propensity and responses to fluoxetine treatment. Epilepsy and Behavior. 2017. V. 68. P. 95-102. DOI: 10.1016/j.yebeh.2016.12.025.
  14. Sarkisova K.Y., Gabova A.V., Kulikov M.A., Fedosova E.A., Shatskova A.B., Morosov A.A. Rearing by foster Wistar mother with high level of maternal care counteracts the development of genetic absence epilepsy and comorbid depression in WAG/Rij rats. Doklady Biological Sciences. 2017. V. 473. N. 1. P. 39-42. DOI: 10.1134/S0012496617020077.
  15. Sarkisova K.Y., Tanaeva K.K., Dobryakova Y.V. Conditional reaction of place choice associated with chidren and mother care for depressive WAG/Rij rats. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 2. P. 229-241.
  16. Sarkisova K.Y., Fedotova I.R., Surina N.M., Nikolaev G.M., Perepelkina O.V., Poletaeva I.I. The effect of chronic fluoxetine administration on audiogenic epilepsy, symptoms of anxiety and depression in four rats. Doklady Akademii Nauk. 2016. V. 467. N. 2. P. 238-241.
  17. Sarkisova K.Y., Fedotova I.R., Surina N.M., Nikolaev G.M., Perepelkina O.V., Poletaeva I.I. Effect of chronic fluoxetine treatment on audiogenic epilepsy, symptoms of anxiety and depression in rats of four lines. Doklady Biological Sciences. 2016. V. 467. N. 1. P. 55-58. DOI: 10.1134/S0012496616020058.
  18. Loseva E.V., Sarkisova K.Y., Loginova N.A., Kudrin V.S. Depressive behavior and consistency of monoamins in brain structures for rats with chronic boredom. Bulleten Eksperimentalnoj Meditsyny. 2015. V. 159. N. 3. P. 304-308.
  19. Fedosova E.A., Sarkisova K.Y., Kudrin V.S., Narkevich V.B., Bazyan A.S. Behavioral and neurochemical characteristics of two months old WAG/Rij rats with genetic absence epilepsy. International Journal of Clinical and Experimental Neurology. 2015. V. 3. N. 2. P. 32-44. DOI: 10.12691/ijcen-3-2-2.
  20. Loseva E.V., Sarkisova K.Y., Loginova N.A., Kudrin V.S. Depressive Behavior and Monoamine Contents in Brain Structures of Rats During Chronic Overcrowding. Bulletin of Experimental Biology and Medicine. 2015. V. 159. N. 3. P. 327-330. DOI: 10.1007/s10517-015-2953-2.
  21. Sarkisova K.Y., Kulikov M.A., Kudrin V.S., Midzyanovskaya I.S., Biryukova L.M. Age-related changes in behavior, in monoamines and their metabolites content, and in density of Dl and D2 dopamine receptors in the brain structures of WAG/Rij rats with depression-like pathology. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2014. V. 64. N. 6. P. 668-685. DOI: 10.7868/S0044467714060094.
  22. Sarkisova K.Y., Kulikov M.A., Kudrin V.S., Narkevich V.B., Midzyanovskaya I.S., Biryukova E.V., Folomkina A.A., Bazyan A.S. Neurochemical mechanisms of depression-like behavior in WAG/Rij rats. Zhurnal vyssheǐ nervnoǐ deiatelnosti imeni I P Pavlova. 2013. V. 63. N. 3. P. 303-315. DOI: 10.7868/S0044467713030106.
  23. Sarkisova K.Y., VanLuijtelaar G. The WAG/Rij strain: A genetic animal model of absence epilepsy with comorbidity of depressiony. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2011. V. 35. N. 4. P. 854-876. DOI: 10.1016/j.pnpbp.2010.11.010.
  24. Sarkisova K.Y., Novikova M.R., Zaichenko M.I., Paramokhin M.L., Gadalin Y.S., Gulyaeva N.V. Remote control of the goal-directed behavior of freely moving rats by telestimulation of the rewarding brain structures. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2010. V. 60. N. 2. P. 236-246.
  25. Sarkisova K.Y., Kuznetsova G.D., Kulikov M.A., VanLuijtelaar G. Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms. Epilepsia. 2010. V. 51. N. 1. P. 146-160. DOI: 10.1111/j.1528-1167.2009.02260.x.
  26. Sarkisova K.Y., Kulikov M.A. Behavioral characteristics of WAG/Rij rats susceptible and non-susceptible to audiogenic seizures. Behavioural Brain Research. 2006. V. 166. N. 1. P. 9-18. DOI: 10.1016/j.bbr.2005.07.024.
  27. Sarkisova K.Y., Midzyanovskaya I.S., Kulikov M.A. Depression-like behavioral alterations and c-fos expression in the dopaminergic brain regions in WAG/Rij rats with genetic absence epilepsy. Behavior and Brain Research. 2003. V. 144. N. 1-2. P. 211-226. DOI: 10.1016/S0166-4328(03)00090.
  28. Sarkisova K.Y., Midzyanovskaya I.S., Kulikov M.A. Depression-like change in behaviour and expression of c-fos gene in dopaminergic brain structures in Wag/Rij rats. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2002. V. 52. N. 6. P. 733-742.
  29. Sarkisova K.Y., Kulikov M.A. Profilactic effect of antioxidant AEKOL on behavioral (psychoemotional) disturbances caused by chronic stress in rats. Rossijskij Fiziologicheskij Zhurnal im I M Sechenova. 2000. V. 86. N. 5. P. 557-564.
  30. Sarkisova K.Y., Kulikov M.A. Wag/Rij rats: new genetically determined model of animal depression?. Doklady Academii Nauk. 2000. V. 374. N. 6. P. 732-775.
 

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