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Lyudmila V. Vinogradova

D.Sc. in Biology, Leading Scientist

spreading depression, epilepsy

Laboratory of Molecular Neurobiology

Scopus ID
Web of Science ResearcherID
SPIN code

Chapters in books, books

  • Vinogradova L.V., Kuznetsova G.D., Coenen A.M.L. Audiogenic seizures associated with a corticco-striatal spreading depression wave are accompanied by a long-term suppression of spike-wave discharges. In: The WAG/Rij Model of Absence Epilepsy: The Nijmegen-Russian Federation Papers (Eds. G. Van Luijtellar, G.D. Kuznetsova, A. Coenen, S.A. Chepurnov), 2004, NICI, The Netherland, p. 239-247.
  • Koroleva V.I., Gorelova N.A., Vinogradova L.V. Depression of Leao in different brain structures. 1993. Moscow; Science Publishing, 144 pp. (Russian)
  • Bures J., Koroleva V.I., Vinogradova L.V. Synergetics of spreading depression: re-entry waves and reverberations in the rat brain. In: Spreading Depression (Ed. Do Carmo), 1992, Springer-Verlag, p. 35-48.
  • Koroleva V.I., Gorelova N.A., Vinogradova L.V. Thalamic and hippocampal spreading depression: some electrophysiological and behavioral evidence. In: Spreading Depression (Ed. Do Carmo), 1992, Springer-Verlag, p. 99-115.

Publication list

  1. Karan A.A., Spivak Y.S., Gerasimov K.A., Suleymanova E.M., Volobueva M.N., Kvichanskiy A.A., Vinogradova L.V., Bolshakov A.P. CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex. Molecular Neurobiology. 2021. DOI: 10.1007/s12035-021-02395-w.
  2. Nikitin E.S., Vinogradova L.V. Potassium channels as prominent targets and tools for the treatment of epilepsy. Expert Opinion On Therapeutic Targets. 2021. V. 6. P. 1-13. DOI: 10.1080/14728222.2021.1908263.
  3. Vinogradova L.V., Rysakova M.P., Pavlova I.V. Small damage of brain parenchyma reliably triggers spreading depolarization. Neurological Research. 2020. V. 42. N. 1. P. 76-82. DOI: 10.1080/01616412.2019.1709745.
  4. Vinogradova L.V., Suleymanova E.M., Medvedeva T.M. Transient loss of interhemispheric functional connectivity following unilateral cortical spreading depression in awake rats. Cephalalgia. 2020. V. 8. P. 333102420970172. DOI: 10.1177/0333102420970172.
  5. Suleymanova E.M., Borisova M.A., Vinogradova L.V. Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model. Epilepsy &amp; Behavior. 2019. V. 92. P. 71-78. DOI: 10.1016/j.yebeh.2018.12.001.
  6. Vinogradova L.V. Initiation of spreading depression by synaptic and network hyperactivity: Insights into trigger mechanisms of migraine aura. Cephalalgia. 2018. V. 38. N. 6. P. 1177-1187. DOI: 10.1177/0333102417724151.
  7. Vinogradova L.V., Shatskova A.B. Localizing and lateralizing values of postictal behavioral impairments in epileptic rats. Epilepsy &amp; Behavior. 2018. V. 87. P. 195-199. DOI: 10.1016/j.yebeh.2018.07.016.
  8. Vinogradova L.V. Audiogenic kindling and secondary subcortico-cortical epileptogenesis: Behavioral correlates and electrographic features. Epilepsy and Behavior. 2017. V. 71. P. 142-153. DOI: 10.1016/j.yebeh.2015.06.014.
  9. Suleymanova E.M., Shangaraeva V.A., VanRijn C.M., Vinogradova L.V. The cannabinoid receptor agonist WIN55.212 reduces consequences of status epilepticus in rats. Neuroscience. 2016. V. 334. P. 191-200. DOI: 10.1016/j.neuroscience.2016.08.004.
  10. Sysoeva M.V., Vinogradova L.V., Kuznetsova M.A., Sysoev I.V., VanRijn C.M. Changes in corticocortical and corticohippocampal network during absence seizures in WAG/Rij rats revealed with time varying Granger causality. Epilepsy and Behavior. 2016. V. 64. P. 44-50. DOI: 10.1016/j.yebeh.2016.08.009.
  11. Vinogradova L.V., Grinenko O.A. Ictal electrographic pattern of focal subcortical seizures induced by sound in rats. Brain Research. 2016. V. 1635. P. 161-168. DOI: 10.1016/j.brainres.2016.01.027.
  12. Vinogradova L.V. Comparative potency of sensory-induced brainstem activation to trigger spreading depression and seizures in the cortex of awake rats: Implications for the pathophysiology of migraine aura. Cephalalgia. 2015. V. 35. N. 11. P. 979-986. DOI: 10.1177/0333102414565672.
  13. Vinogradova L.V., VanRijn C.M. Long-term disease-modifying effect of the endocannabinoid agonist WIN55,212-2 in a rat model of audiogenic epilepsy. Pharmacological Reports. 2015. V. 67. N. 3. P. 501-503. DOI: 10.1016/j.pharep.2014.12.002.
  14. Samotaeva I.S., Tillmanns N., VanLuijtelaar G., Vinogradova L.V. Intracortical microinjections may cause spreading depression and suppress absence seizures. Neuroscience. 2013. V. 230. P. 50-55. DOI: 10.1016/j.neuroscience.2012.11.013.
  15. Vinogradova L.V., Shatskova A.B. Lateral asymmetry of early seizure manifestations in experimental generalized epilepsy. Neuroscience. 2012. V. 213. P. 133-143. DOI: 10.1016/j.neuroscience.2012.03.060.
  16. VanRijn C.M., Perescis M.F., Vinogradova L.V., VanLuijtelaar G. Endocannabinoid system protects against cryptogenic seizures. Pharmacological Reports. 2011. V. 63. N. 1. P. 165-168.
  17. Vinogradova L.V., Shatskova A.B., VanRijn C.M. Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy. Epilepsy Research. 2011. V. 96. N. 3. P. 250-256. DOI: 10.1016/j.eplepsyres.2011.06.007.
  18. Vinogradova L.V. Interhemispheric difference in susceptibility to epileptogenesis: Evidence from the audiogenic kindling model in Wistar rats. Brain Research. 2010. V. 1329. P. 175-181. DOI: 10.1016/j.brainres.2010.03.037.
  19. Vinogradova L.V., Kuznetsova M.A., Coenen A.M. Unilateral cortical spreading depression induced by sound in rats. Brain Research. 2009. V. 1286. P. 201-207. DOI: 10.1016/j.brainres.2009.06.047.
  20. Vinogradova L.V. Audiogenic kindling in Wistar and WAG/Rij rats: Kindling-prone and kindling-resistant subpopulations. Epilepsia. 2008. V. 49. N. 10. P. 1665-1674. DOI: 10.1111/j.1528-1167.2008.01617.x.
  21. Vinogradova L.V., VanRijn C.M. Anticonvulsive and antiepileptogenic effects of levetiracetam in the audiogenic kindling model. Epilepsia. 2008. V. 49. N. 7. P. 1160-1168. DOI: 10.1111/j.1528-1167.2008.01594.x.
  22. Vinogradova L.V., Shatskova A.B., Tuomisto L. Histaminergic modulation of acoustically induced running behavior in rats. Brain Research. 2007. V. 1148. N. 1. P. 198-204. DOI: 10.1016/j.brainres.2007.02.017.
  23. Vinogradova L.V., Vinogradov V.Y., Kuznetsova G.D. Unilateral cortical spreading depression is an early marker of audiogenic kindling in awake rats. Epilepsy Research. 2006. V. 71. N. 1. P. 64-75. DOI: 10.1016/j.eplepsyres.2006.05.014.
  24. Vinogradova L.V., Kuznetsova G.D., Coenen A.M. Audiogenic seizures associated with a cortical spreading depression wave suppress spike-wave discharges in rats. Physiology and Behavior. 2005. V. 86. N. 4. P. 554-558. DOI: 10.1016/j.physbeh.2005.08.017.
  25. Vinogradova L.V., Kuznetsova G.D., Shatskova A.B., VanRijn C.M. Vigabatrin in low doses selectively suppresses the clonic component of audiogenically kindled seizures in rats. Epilepsia. 2005. V. 46. N. 6. P. 800-810. DOI: 10.1111/j.1528-1167.2005.52604.x.
  26. Vinogradova L.V. Audiogenic kindling in WAG/Rij rats: change in behavioral and electrophysiological responses to repetitive short acoustic stimulation. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2004. V. 54. N. 5. P. 638-647.
  27. Midzyanovskaya I.S., Kuznetsova G.D., Vinogradova L.V., Shatskova A.B., Coenen A.M., VanLuijtelaar G. Mixed forms of epilepsy in a subpopulation of WAG/Rij rats. Epilepsy and Behavior. 2004. V. 5. N. 5. P. 655-661. DOI: 10.1016/j.yebeh.2004.06.021.
  28. Koroleva V.I., Vinogradova L.V. Ischemic and hypoxic depolarization in the rat neocortex. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2000. V. 50. N. 4. P. 612-623.
  29. Koroleva V.I., Vinogradova L.V., Korolev O.S. The persistent negative potential provoked in different structures of the rat brain by a single wave of spreading cortical depression. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1998. V. 48. N. 4. P. 654-663.
  30. Vinogradova L.V., Koroleva V.I. Spreading depression in the corticostriatal system of the rat brain during a seizure process induced by the daily administration of pentylenetetrazole. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1993. V. 43. N. 4. P. 683-694.
  31. Koroleva V.I., Vinogradova L.V., Bures J. Reduced incidence of cortical spreading depression in the course of pentylenetetrazol kindling in rats. Brain Research. 1993. V. 608. N. 1. P. 107-114. DOI: 10.1016/0006-8993(93)90780-Q.
  32. Koroleva V.I., Gorelova N.A., Vinogradova L.V. The electrophysiological characteristics and behavioral manifestations of hippocampal and thalamic spreading depression. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1991. V. 41. N. 5. P. 1019-1032.
  33. Vinogradova L.V., Koroleva V.I., Bures J. Re-entry waves of Leao's spreading depression between neocortex and caudate nucleus. Brain Research. 1991. V. 538. N. 1. P. 161-164. DOI: 10.1016/0006-8993(91)90392-9.
  34. Koroleva V.I., Vinogradova L.V. Spreading depression in the thalamus, hippocampus and caudate nucleus of the rat during electrical stimulation of the parietal area of the cortex. Nejrofiziologija. 1990. V. 22. N. 1. P. 36-44.

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