Laboratory of Neuroontogenesis

Brief history of the laboratory

The laboratory of neuroontogenesis was formed in 1989 and belongs to the scientific school of academician Peter Kuzmich Anokhin. The laboratory develops ideas about system genesis, developmental heterochronies and functional systems. Her origins are Kira Vasilyevna Shuleykina and Sergey Naumovich Khayutin. Laboratory research aims to solve the following problems: · the role of environmental factors (afferent influx) in the formation of the structure and functions of the developing brain. · The study of the role of early sensory experience in the formation of memory and learning of adult animals. · The study of the structural and functional bases of the formation of early forms of behavior and the modification of their sensory support in the subsequent stages of postnatal ontogenesis. · Study of integrative interactions in the nervous system during normal ontogenesis, under conditions of restriction of sensory input and with genetically determined developmental disorders.

Список сотрудников

Publication list

Papers

Iotchev I.B., Perevozniuk D.A., Lazarenko I., Perescis M.F.J., Sitnikova E.Y., van Luijtelaar G. The "Twin Peaks" method of automated Spike-Wave detection: A two-step, two-criteria Matlab application. Journal Of Neuroscience Methods. 2024. V. 409. P. 110199. DOI: 10.1016/j.jneumeth.2024.110199
Perevozniuk D., Lazarenko I., Semenova N., Sitnikova E.Y. A simple and fast ANN-based method of studying slow-wave sleep microstructure in freely moving rats. Biosystems. 2024. V. 235. P. 105112. DOI: 10.1016/j.biosystems.2023.105112
Sitnikova E.Y. Behavioral and Cognitive Comorbidities in Genetic Rat Models of Absence Epilepsy (Focusing on GAERS and WAG/Rij Rats). Biomedicines. 2024. V. 12. N. 1. P. 122. DOI: 10.3390/biomedicines12010122
Sitnikova E.Y., Onat F., van Luijtelaar G. Editorial: Epileptic seizure disorders in animal models: advances in translational approaches. Front. Neurol.. 2024. V. 15. P. 1414940. DOI: 10.3389/fneur.2024.1414940
Sitnikova E.Y., van Luijtelaar G., Onat F. Epileptic seizure disorders in animal models: Advances in translational approaches. doi: 10.3389/978-2-8325-4854-7. Lausanne: Frontiers Media SA. 2024. 109 p.
Alexandrov P., Pupikina M., Adaeva Z., Sitnikova E.Y. The Difference between Male and Female Rats in Terms of Freezing and Aversive Ultrasonic Vocalization in an Active Avoidance Test. Physiologia. 2023. V. 3. P. 406-420. DOI: 10.3390/physiologia3030028
Carcak N., Onat F., Sitnikova E.Y. Astrocytes as a target for therapeutic strategies in epilepsy: current insights. Frontiers In Molecular Neuroscience. 2023. V. 16. P. 1183775. DOI: 10.3389/fnmol.2023.1183775
Pupikina M., Sitnikova E.Y. Sex Differences in Behavior and Learning Abilities in Adult Rats. Life. 2023. V. 13. N. 2. P. 547. DOI: 10.3390/life13020547
Rebik A.A., Broshevitskaya N., Kuzhuget S., Aleksandrov P., Abbasova K., Zaichenko M.I., Midzyanovskaya I.S. Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky–Molodkina Rats. Biomedicines. 2023. N. 11. P. 2566. DOI: 10.3390/biomedicines11092566
Sergeev K., Runnova A., Zhuravlev M., Sitnikova E.Y., Rutskova E.M., Smirnov K.S., Slepnev A., Semenova N. Simple method for detecting sleep episodes in rats ECoG using machine learning. Chaos, Solitons & Fractals. 2023. V. 173. N. April. P. 113608. DOI: 10.1016/j.chaos.2023.113608
Sitnikova E.Y. Adrenergic mechanisms of absence status epilepticus. Frontiers in Neurology. 2023. V. 14. P. 1298310. DOI: 10.3389/fneur.2023.1298310
Sitnikova E.Y., Pupikina M., Rutskova E.M. Alpha2 Adrenergic Modulation of Spike-Wave Epilepsy: Experimental Study of Pro-Epileptic and Sedative Effects of Dexmedetomidine. International Journal of Molecular Sciences. 2023. V. 24. N. 11. P. 9445. DOI: 10.3390/ijms24119445
Sitnikova E.Y., Rutskova E.M., Smirnov K.S. Alpha2-Adrenergic Receptors as a Pharmacological Target for Spike-Wave Epilepsy. International Journal of Molecular Sciences. 2023. V. 24. N. 2. P. 1477. DOI: 10.3390/ijms24021477
Esmaeili A., Antonova A., Sitnikova E.Y., Smirnov K.S. Whisker trimming during infanthood modifies the development of spike-wave discharges and behavioral sequences in IntelliCage impulsivity paradigm in adult WAG/Rij rats. Behavioural Brain Research. 2022. V. 418. P. 113627. DOI: 10.1016/j.bbr.2021.113627
Neklyudova A.K., Smirnov K.S., Rebreikina A.B., Martynova O.V., Sysoeva O.V. Electrophysiological and Behavioral Evidence for Hyper- and Hyposensitivity in Rare Genetic Syndromes Associated with Autism. Genes. 2022. V. 13. N. 4. P. 671. DOI: 10.3390/genes13040671
Rebik A.A., Riga V.D., Smirnov K.S., Sysoeva O.V., Midzyanovskaya I.S. Social Behavioral Deficits in Krushinsky-Molodkina Rats, an Animal Model of Audiogenic Epilepsy. Journal Of Personalized Medicine. 2022. V. 12. N. 12. P. 2062. DOI: 10.3390/jpm12122062
Sitnikova E.Y., Perevozniuk D., Rutskova E.M., Uzakov S.S., Korshunov V.A. Reduction of Hippocampal High-Frequency Activity in Wag/Rij Rats with a Genetic Predisposition to Absence Epilepsy. Diagnostics. 2022. V. 12. P. 2798. DOI: 10.3390/diagnostics12112798
Sitnikova E.Y., Rutskova E.M., Smirnov K.S., Runnova A., Zhuravlev M. Intracortical synchronization pattern on the preclinical and clinical stages of absence epilepsy (analysis of wavelet bicoherence in WAG/Rij rats). The european physical journal special topics. 2022. DOI: 10.1140/epjs/s11734-022-00719-y
Zhuravlev M., Runnova A., Smirnov K., Sitnikova E. Spike-Wave Seizures, NREM Sleep and Micro-Arousals in WAG/Rij Rats with Genetic Predisposition to Absence Epilepsy: Developmental Aspects. Life. 2022. V. 12. N. 4. P. 576. DOI: 10.3390/life12040576
Hramov A.E., Koronovskii A.A., Makarov V.A., Maksimenko V., Pavlov A.N., Sitnikova E.Y. Wavelets in Neuroscience. Switzerland AG: Springer International Publishing. 2021. 384 p.
Korneeva E.V., Tiunova A.A., Alexandrov L.I., Golubeva T.B. Influence of Natural Asymmetric Embryonic Visual Afferentation on the Neuronal Activations in the Caudomedial Mesopallium during the Freezing Response in Altricial Nestlings. Doklady Biological Sciences. 2021. V. 497. N. 1. P. 62-64. DOI: 10.1134/S0012496621020046
Levichkina E.V., Busygina I.I., Pigareva M.L., Pigarev I.N. The Mysterious Island: Insula and Its Dual Function in Sleep and Wakefulness. Frontiers In Systems Neuroscience. 2021. V. 14. P. 592660. DOI: 10.3389/fnsys.2020.592660
Runnova A., Zhuravlev M., Kiselev A., Ukolov R., Smirnov K.S., Karavaev A., Sitnikova E.Y. Automatic wavelet-based assessment of behavioral sleep using multichannel electrocorticography in rats. Sleep and Breathing. 2021. V. 25. N. 4. P. 2251-2258. DOI: 10.1007/s11325-021-02357-5
Runnova A., Zhuravlev M., Ukolov R., Blokhina I., Dubrovski A., Lezhnev N., Sitnikova E.Y., Saranceva E., Kiselev A., Karavaev A., Selskii A., Semyachkina-Glushkovskaya O., Penzel T., Kurths J. Modified wavelet analysis of ECoG-pattern as promising tool for detection of the blood-brain barrier leakage. Scientific Reports. 2021. V. 11. N. 1. P. 18505. DOI: 10.1038/s41598-021-97427-9
Sitnikova E.Y. Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij). Frontiers in Neurology. 2021. V. 12. P. 766566. DOI: 10.3389/fneur.2021.766566
Sitnikova E.Y., Rutskova E.M., Tsvetaeva D., Raevsky V.V. Spike-wave seizures, slow-wave sleep EEG and morphology of substantia nigra pars compacta in WAG/Rij rats with genetic predisposition to absence epilepsy. Brain Research Bulletin. 2021. V. 174. P. 63-71. DOI: 10.1016/j.brainresbull.2021.06.003
Sitnikova E.Y., Smirnov K.S., Raevsky V.V. Sensory Inflow from Whiskers Modulates Development of Absence Epilepsy in WAG/Rij Rats. Advances in Intelligent Systems and Computing. 2021. V. 1358 AIST. P. 510-519. DOI: 10.1007/978-3-030-71637-0_59
Smirnov K.S., Stroganova T., Molholm S., Sysoeva O.V. Reviewing Evidence for the Relationship of EEG Abnormalities and RTT Phenotype Paralleled by Insights from Animal Studies. International Journal Of Molecular Sciences. 2021. V. 22. N. 10. P. 5308. DOI: 10.3390/ijms22105308
Ukolov R., Zhuravlev M., Kustodov S., Sitnikova E.Y. The changes of oscillation patterns in experimental signals by behavioral sleeping and wakefulness. // Saratov Fall Meeting 2020: Computations and Data Analysis: from Molecular Processes to Brain Functions. 2021. V. Proc. SPIE 11847. 118470M.
Sitnikova E.Y. Thalamo-cortical dysrhythmia and its diagnostic principles. Izvestiya VUZ. Applied Nonlinear Dynamics. 2020. V. 28. N. 3. 282–298. DOI: 10.18500/0869-6632-2020-28-3-282-298
Midzyanovskaya I.S., Petrenko N.E., Biryukova L.M., Tuomisto L.M. Reduced H3 histamine receptor binding densities in the upper layers of motor cortex in rats prone to audiogenic convulsive seizures. Epilepsy Research. 2020. V. 170. P. 106543. DOI: 10.1016/j.eplepsyres.2020.106543
Pigarev I.N., Pigareva M.L., Levichkina E.V. Probable Mechanism of Antiepileptic Effect of the Vagus Nerve Stimulation in the Context of the Recent Results in Sleep Research. Frontiers In Neuroscience. 2020. V. 14. P. 160. DOI: 10.3389/fnins.2020.00160
Romanova D.Y., Smirnov K.S., Nikitin M.A., Kohn A.B., Borman A.I., Malyshev A.Y., Balaban P.M., Moroz L.L. Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals. Biochemical And Biophysical Research Communications. 2020. V. 532. N. 1. P. 120-126. DOI: 10.1016/j.bbrc.2020.08.020
Sharova E.V., Kotovich Ju.V., Deza-Araujo Y.I., Smirnov K.S., Gavron A.A., Fadeeva L.M., Chelyapina-Postnikova M.V., Alexandrova E.V., Vronkova L.A., Boldyreva G.N., Verkhlyutov V.M., Kornienko V.N., Pronin I.N. fMRI resting state networks visualization in patients with severe traumatic brain injury. Medical Visualization. 2020. V. 24. N. 1. P. 68-84. DOI: 10.24835/1607-0763-2020-1-68-84
Sitnikova E., Smirnov K.S. Active avoidance learning in WAG/Rij rats with genetic predisposition to absence epilepsy. Brain Research Bulletin. 2020. V. 165. P. 198-208. DOI: 10.1016/j.brainresbull.2020.10.007
Sitnikova E.Y., Smirnov K.S., Grubov V.V., Hramov A.E. Diagnostic principles of immature epileptic (proepileptic) EEG activity in rats with genetic predisposition to absence epilepsy. Informatsionno-Upravliaiushchie Sistemy. 2019. V. 1. P. 89-97. DOI: 10.31799/1684-8853-2019-1-89-97
Pigarev I., Pigareva M.L. Progress in Sleep Studies in the Epoch of Electrophysiology. The Visceral Theory of Sleep. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 7. P. 903-909. DOI: 10.1007/s11055-019-00817-w
Pigarev I.N., Pigareva M.L., Levichkina E.V. On the mechanism of therapeutic effects of electrostimulation. Interpretations and predictions based on the results of sleep studies. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2019. V. 119. N. 4. P. 15-21. DOI: 10.17116/jnevro201911904215
Sitnikova E., Grubov V., Hramov A.E. Slow-wave activity preceding the onset of 10-15-Hz sleep spindles and 5-9-Hz oscillations in electroencephalograms in rats with and without absence seizures. Journal Of Sleep Research. 2019. V. 29. N. 6. e12927. DOI: 10.1111/jsr.12927
Smirnov K., Sitnikova E. Developmental milestones and behavior of infant rats: The role of sensory input from whiskers. Behavioural Brain Research. 2019. V. 374. P. 112143. DOI: 10.1016/j.bbr.2019.112143
Sysoeva O.V., Smirnov K., Stroganova T.A. Sensory evoked potentials in patients with Rett syndrome through the lens of animal studies: Systematic review. Clinical Neurophysiology. 2019. V. 131. N. 1. P. 213-224. DOI: 10.1016/j.clinph.2019.11.003
Tsvetaeva D.A., Sitnikova E.Y., Raevsky V.V. Cortical Somatosensory Neurons in WAG/Rij Rats Transform Firing Evoked by Simulation of Posterior Thalamic Nucleus from Tonic to Phasic at Age of 6 Months. Bulletin Of Experimental Biology And Medicine. 2019. V. 168. N. 1. P. 1-4. DOI: 10.1007/s10517-019-04632-8
Tsvetaeva D.A., Raevsky V.V., Sitnikova E.Y. Peculiarities of somatosensory cortex neuron responses to stimulation of the posterior thalamus (PO) in WAG / Rij rats genetically predisposed to abscess epilepsy. Doklady Akademii Nauk. 2018. V. 480. N. 3. P. 373-376. DOI: 10.7868/S0869565218150240
Shishelova A.Y., Raevsky V.V. The influence of pre- and postnatal factors on the formation of early behavioral reactions. Doklady Akademii Nauk. 2018. V. 479. N. 3. P. 351-353. DOI: 10.7868/S0869565218090268
Pigarev I.N., Pigareva M.L. Progress of sleep studies in the age of electrophysiology. The visceral theory of sleep. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2018. V. 118. N. 4. P. 5-13. DOI: 10.17116/jnevro2018118425
Pigarev I.N., Pigareva M.L. Therapeutic Effects of Electrical Stimulation: Interpretations and Predictions Based on the Visceral Theory of Sleep. Frontiers In Neuroscience. 2018. V. 12. P. 65. DOI: 10.3389/fnins.2018.00065
Smirnov K., Tsvetaeva D., Sitnikova E. Neonatal whisker trimming in WAG/Rij rat pups causes developmental delay, encourages maternal care and affects exploratory activity in adulthood. Brain Research Bulletin. 2018. V. 140. P. 120-131. DOI: 10.1016/j.brainresbull.2018.04.010
Tsvetayeva D.A., Sitnikova E.Y., Raevsky V.V. The Responses of Neurons of the Somatosensory Cortex to Stimulation of the Posterior Thalamus (PO) in WAG/Rij Rats Genetically Predisposed to Absence Epilepsy. Doklady Biological Sciences. 2018. V. 480. N. 1. P. 75-77. DOI: 10.1134/S0012496618030109
Runova A.E., Zhuravleva M.O., Sitnikova E.Y., Koronosvky A.A., Khromov A.E. Method for removing oculomotor artifacts on human EEG in recognition of ambiguous visual image. Informatsionno-upravlyajuchije sisstemy. 2017. V. 5. P. 105-112. DOI: 10.15217/issn1684-8853.2017.5.10
Grubov V., Sitnikova E.Y., Pavlov A.N., Koronovskii A.A., Hramov A.E. Recognizing of stereotypic patterns in epileptic EEG using empirical modes and wavelets. Physica A: Statistical Mechanics and its Applications. 2017. V. 486. P. 206-217. DOI: 10.1016/j.physa.2017.05.091