Laboratory of Cellular Neurobiology of Learning
Brief history and main directions of scientific work of the laboratory
The laboratory was established in 1989 on the basis of a group that conducted research on invertebrate animals, which was part of the laboratory of academician P.V. Simonov. The main directions of scientific work are cellular mechanisms of behavior organization and behavior modifications as a result of learning, cellular and molecular mechanisms of memory. Along with traditional electrophysiological methods, optical methods of recording and confocal microscopy are actively used in the laboratory. As an object of study, animals with a simple nervous system or brain slices of vertebrates are used. International cooperation with Yale University (USA) in the field of optical methods, with the University of Arizona (USA) in the analysis of neural networks of pantopus mollusks, with the Institute of Neurophysiology of the University of Bochum (Germany) and with the University of Connecticut (USA) in the field of synaptic plasticity mechanisms.
Books in English
- Balaban P.M. (2002) Declarative and procedural memory in animals with simple nervous systems. In: "Psychology at the turn of the millennium, Vol. 1: Cognitive, biological, and health perspectives" (Eds: Lars Bäckman & Claes von Hofsten). Psychology Press, pp. 1-28.
- Balaban P.M. Applicability of the reinforcement concept to studies in simple nervous systems. In: Complex Brain Functions. Conceptual Advances in Russian Neuroscience. Eds. A.M.Ivanitsky, P.M.Balaban, Harwood Academic Publishers, 2000, p.201-211.
Список сотрудников
Publication list
Papers
- Aseyev N.A., Zakharov I.S., Balaban P.M. Morphology of neuropeptide CNP2 modulation of heart activity in terrestrial snail. Peptides. 2010. V. 31. N. 7. P. 1301-1308. DOI: 10.1016/j.peptides.2010.04.006
- Baranauskas G., Mukovskiy A., Wolf F., Volgushev M.A. The determinants of the onset dynamics of action potentials in a computational model. Neuroscience. 2010. V. 167. N. 4. P. 1070-1090. DOI: 10.1016/j.neuroscience.2010.02.072
- Chauvette S., Volgushev M.A., Timofeev I. Origin of active states in local neocortical networks during slow sleep oscillation. Cerebral Cortex. 2010. V. 20. N. 11. P. 2660-2674. DOI: 10.1093/cercor/bhq009
- Ierusalimsky V.N., Balaban P.M. Two morphological sub-systems within the olfactory organs of a terrestrial snail. Brain Research. 2010. V. 1326. P. 68-74. DOI: 10.1016/j.brainres.2010.02.060
- Tchumatchenko T., Geisel T., Volgushev M.A., Wolf F. Signatures of synchrony in pairwise count correlations. Frontiers in Computational Neuroscience. 2010. V. 4. P. 1. DOI: 10.3389/neuro.10.001.2010
- Tchumatchenko T., Malyshev A.Y., Geisel T., Volgushev M.A., Wolf F. Correlations and synchrony in threshold neuron models. Physical Review Letters. 2010. V. 104. N. 5. P. 058102. DOI: 10.1103/PhysRevLett.104.058102
- Vavoulis D.V., Nikitin E.S., Kemenes I., Marra V., Feng J., Benjamin P.R., Kemenes G. Balanced plasticity and stability of the electrical properties of a molluscan modulatory interneuron after classical conditioning: A computational study. Frontiers in Behavioral Neuroscience. 2010. V. 4. P. 19. DOI: 10.3389/fnbeh.2010.00019
- Marchenko V.G., Saltykov K.A. Mechanisms of synchronization in local neocortex networks. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2009. V. 59. N. 6. P. 738-747.
- Malyshev A.Y., Balaban P.M. Buccal neurons activate ciliary beating in the foregut of the pteropod mollusk Clione limacina. Journal of Experimental Biology. 2009. V. 212. N. 18. P. 2969-2976. DOI: 10.1242/jeb.032227
- Samarova E., Balaban P.M. Changes in frequency of spontaneous oscillations in procerebrum correlate to behavioural choice in terrestrial snails. Frontiers in Cellular Neuroscience. 2009. V. 3. N. AUG. P. 8. DOI: 10.3389/neuro.03.008.2009
- Marchenko V.G., Pasikova N.V. Synchronization of electrical field potentials in neocortex of rat after isolation of a cortex island in the contralateral brain hemisphere. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2008. V. 58. N. 1. P. 88-97.
- Balaban P.M. Cellular mechanisms of behavioral plasticity in simple nervous systems. Neuroscience and Behavioral Physiology. 2008. V. 38. N. 5. P. 453-459. DOI: 10.1007/s11055-008-9002-9
- Korshunova T.A., Bravarenko N.I., Balaban P.M. Impairment of context memory by beta-amyloid peptide in terrestrial snail. Front. Behav. Neurosci.. 2008. V. 2. N. 2. P. 3. DOI: 10.3389/neuro.08/003.2008
- Korshunova T.A., Samarova E.I., Bravarenko N.I., Balaban P.M. Effects of β-amyloid (25-35) on learning in the common snail. Neuroscience and Behavioral Physiology. 2008. V. 38. N. 4. P. 377-382. DOI: 10.1007/s11055-008-0054-7
- Malyshev A.Y., Norekian T.P., Balaban P.M. Neural control of heartbeat during two antagonistic behaviors: Whole body withdrawal and escape swimming in the Mollusk Clione limacina. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 2008. V. 194. N. 10. P. 899-906. DOI: 10.1007/s00359-008-0362-y
- Nikitin E.S., Korshunova T.A., Zakharov I.S., Balaban P.M. Olfactory experience modifies the effect of odour on feeding behaviour in a goal-related manner. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 2008. V. 194. N. 1. P. 19-26. DOI: 10.1007/s00359-007-0272-4
- Nikitin E.S., Vavoulis D.V., Kemenes I., Marra V., Pirger Z., Michel M., Feng J., O'Shea M., Benjamin P.R., Kemenes G. Persistent Sodium Current Is a Nonsynaptic Substrate for Long-Term Associative Memory. Current Biology. 2008. V. 18. N. 16. P. 1221-1226. DOI: 10.1016/j.cub.2008.07.030
- Volgushev M.A., Malyshev A.Y., Balaban P.M., Chistiakova M., Volgushev S., Wolf F. Onset dynamics of action potentials in rat neocortical neurons and identified snail neurons: Quantification of the difference. PLoS ONE. 2008. V. 3. N. 4. e1962. DOI: 10.1371/journal.pone.0001962
- Balaban P.M. Cellular mechanisms of behavioural plasticity in simple nervous systems. Rossijski Fiziologicheski Zhurnal im I M Sechenova. 2007. V. 93. N. 5. P. 521-530.
- Korshunova T.A., Samarova A.I., Bravarenko N.I., Balaban P.M. Beta-Amyloid Peptide Influences Behavioral Plasticity in Terrestrial Snail. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2007. V. 57. N. 2. P. 229-236.
- Efimova O.I., Ierusalimsky V.N., Anokhin K.V., Balaban P.M. Immunohistochemical detection of the activation of CREB and c-Fos transcription factors in the nervous system of the terrestrial snail induced by pentylenetetrazole. Neuroscience and Behavioral Physiology. 2007. V. 37. N. 9. P. 853-856. DOI: 10.1007/s11055-007-0092-6
- Ierusalimsky V.N., Balaban P.M. Primary sensory neurons containing command neuron peptide constitute a morphologically distinct class of sensory neurons in the terrestrial snail. Cell and Tissue Research. 2007. V. 330. N. 1. P. 169-177. DOI: 10.1007/s00441-007-0447-x
- Ierusalimsky V.N., Balaban P.M. Neuropeptides of Drosophila related to molluscan neuropeptides: Dependence of the immunoreactivity pattern on the ontogenetic stage and functional state. Brain Research. 2007. V. 1152. N. 1. P. 32-41. DOI: 10.1016/j.brainres.2007.03.038
- Lemak M.S., Bravarenko N.I., Bobrov P.D., Bezuglov V.V., Ierusalimsky V.N., Storozhuk M.V., Malyshev A.Y., Balaban P.M. Cannabinoid regulation in identified synapse of terrestrial snail. European Journal of Neuroscience. 2007. V. 26. N. 11. P. 3207-3214. DOI: 10.1111/j.1460-9568.2007.05945.x
- Mukovski M., Chauvette S., Timofeev I., Volgushev M.A. Detection of active and silent states in neocortical neurons from the field potential signal during slow-wave sleep. Cerebral Cortex. 2007. V. 17. N. 2. P. 400-414. DOI: 10.1093/cercor/bhj157
- Samarova E.I., Balaban P.M. Recording of spontaneous oscillations in the procerebrum of the terrestrial snail Helix during free behavior. Neuroscience and Behavioral Physiology. 2007. V. 37. N. 8. P. 773-777. DOI: 10.1007/s11055-007-0081-9
- Balaban P.M., Gulyaeva N.V. Commonality of molecular mechanisms of neuroplasticity and neuropathology: integrative approach. Rossijskij Fiziologicheskij Zhurnal im I M Sechenova. 2006. V. 92. N. 2. P. 145-152.
- Efimova O.I., Ierusalimsky V.N., Anokhin K.V., Balaban P.M. Immunohistochemical detection of transcription factors CREB and c-Fos activation in the land snail nervous system induced by pentylenetetrazole. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2006. V. 56. N. 6. P. 801-804.
- Samarova E.I., Balaban P.M. Recording of spontaneous oscillations in the procerebrum of terrestrial mollusk Helix in free behavior. Zhurnal Vusshei Nervnoi Deiatelnosti im I P Pavlova. 2006. V. 56. N. 6. P. 725-730.
- Balaban P.M., Malyshev A.Y., Ierusalimsky V.N., Aseev N.A., Korshunova T.A., Bravarenko N.I., Lemak M.S., Roschin M.V., Zakharov I.S., Popova Y., Boyle R. Structure and function of the snail statocyst system after a 16-day flight on FOTON-M-2. Journal of Gravitational Physiology. 2006. V. 13. N. 1. P. 2101-2104.
- Bravarenko N.I., Onufriev M.V., Stepanichev M.Y., Ierusalimsky V.N., Balaban P.M., Gulyaeva N.V. Caspase-like activity is essential for long-term synaptic plasticity in the terrestrial snail Helix. European Journal of Neuroscience. 2006. V. 23. N. 1. P. 129-140. DOI: 10.1111/j.1460-9568.2005.04549.x
- Gainutdinova T.K., Tagirova R.R., Ismailova A.I., Muranova L.N., Gainutdinov K.L., Balaban P.M. Protein synthesis-dependent reactivation of a contextual conditioned reflex in the common snail. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 2. P. 203-207. DOI: 10.1007/s11055-005-0179-x
- Ierusalimsky V.N., Balaban P.M. Immunoreactivity to molluskan neuropeptides in the central and stomatogastric nervous systems of the earthworm, Lumbricus terrestris L. Cell and Tissue Research. 2006. V. 325. N. 3. P. 555-565. DOI: 10.1007/s00441-006-0176-6
- Ivanova J.L., Leonova O.G., Popenko V.I., Ierusalimsky V.N., Korshunova T.A., Boguslavsky D.V., Malyshev A.Y., Balaban P.M., Belyavsky A.V. Intracellular localization of the HCS2 gene products in identified snail neurons in vivo and in vitro. Cellular and Molecular Neurobiology. 2006. V. 26. N. 2. P. 127-144. DOI: 10.1007/s10571-006-9025-0
- Kemenes I., Straub V.A., Nikitin E.S., Staras K., O'Shea M., Kemenes G., Benjamin P.R. Role of Delayed Nonsynaptic Neuronal Plasticity in Long-Term Associative Memory. Current Biology. 2006. V. 16. N. 13. P. 1269-1279. DOI: 10.1016/j.cub.2006.05.049
- Korshunova T.A., Malyshev A.Y., Zakharov I.S., Ierusalimskii V.N., Balaban P.M. Functions of peptide CNP4, encoded by the HCS2 gene, in the nervous system of Helix lucorum. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 3. P. 253-260. DOI: 10.1007/s11055-006-0007-y
- Naundorf B., Wolf F., Volgushev M.A. Unique features of action potential initiation in cortical neurons. Nature. 2006. V. 440. N. 7087. P. 1060-1063. DOI: 10.1038/nature04610
- Nikitin E.S., Kiss T., Staras K., O'Shea M., Benjamin P.R., Kemenes G. Persistent sodium current is a target for cAMP-induced neuronal plasticity in a state-setting modulatory interneuron. Journal of Neurophysiology. 2006. V. 95. N. 1. P. 453-463. DOI: 10.1152/jn.00785.2005
- Nikitin E.S., Zakharov I.S., Balaban P.M. Regulation of tentacle length in snails by odor concentration. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 1. P. 63-72. DOI: 10.1007/s11055-005-0163-5
- Norekian T.P., Malyshev A.Y. Neural mechanisms underlying co-activation of functionally antagonistic motoneurons during a Clione feeding behavior. Journal of Neurophysiology. 2006. V. 95. N. 4. P. 2560-2569. DOI: 10.1152/jn.01174.2005
- Volgushev M.A., Chauvette S., Mukovski M., Timofeev I. Precise long-range synchronization of activity and silence in neocortical neurons during slow-wave sleep. Journal of Neuroscience. 2006. V. 26. N. 21. P. 5665-5672. DOI: 10.1523/JNEUROSCI.0279-06.2006
- Korshunova T.A., Malyshev A.Y., Zakharov I.S., Ierusalimsky V.N., Balaban P.M. Functional role of neuropeptide CNP4 encoded by gene HCS2 in Helix lucorum nervous system. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2005. V. 55. N. 1. P. 91-99.
- Aseyev N.A., Ierusalimsky V.N., Boguslavsky D., Balaban P.M. Snail peptide expression pattern in the nervous system of the medicinal leech. Molecular Brain Research. 2005. V. 140. N. 1-2. P. 99-105. DOI: 10.1016/j.molbrainres.2005.06.012
- Beck O., Chistiakova M., Obermayer K., Volgushev M.A. Adaptation at synaptic connections to layer 2/3 pyramidal cells in rat visual cortex. Journal of Neurophysiology. 2005. V. 94. N. 1. P. 363-376. DOI: 10.1152/jn.01287.2004
- Boldyreva G.N., Sharova E.V., Koptelov Y.M., Shchepetkov A.N., Nikitin E.S., Kornienko V.N., Fadeeva L.M. Study of the genesis of pathological EEG patterns in tumor and traumatic lesions of the human brain. Human Physiology. 2005. V. 31. N. 1. P. 18-25. DOI: 10.1007/s10747-005-0003-6
- Bravarenko N.I., Malyshev A.Y., Voronin L.L., Balaban P.M. Ephaptic feedback in identified synapses in mollusk neurons. Neuroscience and Behavioral Physiology. 2005. V. 35. N. 8. P. 781-787. DOI: 10.1007/s11055-005-0124-z
- Gainutdinova T.H., Tagirova R.R., Ismailova A.I., Muranova L.N., Samarova E.I., Gainutdinov K.L., Balaban P.M. Reconsolidation of a context long-term memory in the terrestrial snail requires protein synthesis. Learning and Memory. 2005. V. 12. N. 6. P. 620-625. DOI: 10.1101/lm.25705
- Ierusalimsky V.N., Balaban P.M. Morphological basis for coordination of growth and reproduction processes in the CNS of two terrestrial snails. Experimental Brain Research. 2005. V. 161. N. 4. P. 465-473. DOI: 10.1007/s00221-004-2093-9
- Nikitin E.S., Zakharov I.S., Samarova E.I., Kemenes G., Balaban P.M. Fine tuning of olfactory orientation behaviour by the interaction of oscillatory and single neuronal activity. European Journal of Neuroscience. 2005. V. 22. N. 11. P. 2833-2844. DOI: 10.1111/j.1460-9568.2005.04480.x
- Norekian T.P., Malyshev A.Y. Coordinated excitatory effect of GABAergic interneurons on three feeding motor programs in the mollusk Clione limacina. Journal of Neurophysiology. 2005. V. 93. N. 1. P. 305-315. DOI: 10.1152/jn.00722.2004