Laboratory of Cellular Neurobiology of Learning

Brief history and main directions of scientific work of the laboratory

The laboratory was established in 1989 on the basis of a group that conducted research on invertebrate animals, which was part of the laboratory of academician P.V. Simonov. The main directions of scientific work are cellular mechanisms of behavior organization and behavior modifications as a result of learning, cellular and molecular mechanisms of memory. Along with traditional electrophysiological methods, optical methods of recording and confocal microscopy are actively used in the laboratory. As an object of study, animals with a simple nervous system or brain slices of vertebrates are used. International cooperation with Yale University (USA) in the field of optical methods, with the University of Arizona (USA) in the analysis of neural networks of pantopus mollusks, with the Institute of Neurophysiology of the University of Bochum (Germany) and with the University of Connecticut (USA) in the field of synaptic plasticity mechanisms.

Books in English

Balaban P.M. (2002) Declarative and procedural memory in animals with simple nervous systems. In: "Psychology at the turn of the millennium, Vol. 1: Cognitive, biological, and health perspectives" (Eds: Lars Bäckman & Claes von Hofsten). Psychology Press, pp. 1-28.
Balaban P.M. Applicability of the reinforcement concept to studies in simple nervous systems. In: Complex Brain Functions. Conceptual Advances in Russian Neuroscience. Eds. A.M.Ivanitsky, P.M.Balaban, Harwood Academic Publishers, 2000, p.201-211.

Список сотрудников

Publication list

Papers

Aseyev N.A., Borodinova A.A., Pavlova S.A., Roshchina M.A., Roshchin M.V., Nikitin E.S., Balaban P.M. CADENCE - Neuroinformatics Tool for Supervised Calcium Events Detection. Neuroinformatics. 2024. DOI: 10.1007/s12021-024-09677-3
Li Y., Sun C., Romanova D., Wu D.O., Fang R., Moroz L.L. Analysis and Visualization of Single-Cell Sequencing Data with Scanpy and MetaCell: A Tutorial. Methods in Molecular Biology. 2024. V. 2757. P. 383-445. DOI: 10.1007/978-1-0716-3642-8_17
Luponosov Y.N., Solodukhin A.N., Aseyev N.A., Rokitskaya T.I., Kolotova D.Y., Kotova E.A., Kurkin T.S., Poletavkina L.A., Isaeva Y.A., Antonenko Y.N., Balaban P.M., Ponomarenko S.A. Nanoparticles of Push-Pull Triphenylamine-Based Molecules for Light-Controlled Stimulation of Neuronal Activity. ACS Biomaterials Science & Engineering. 2024. V. 10. N. 2. P. 1139-1152. DOI: 10.1021/acsbiomaterials.3c01562
Nikitin M.A., Romanova D., Moroz L.L. Bioinformatic Prohormone Discovery in Basal Metazoans: Insights from Trichoplax. Methods in Molecular Biology. 2024. V. 2757. P. 531-581. DOI: 10.1007/978-1-0716-3642-8_22
Romanova D., Moroz L.L. Parallel evolution of gravity sensing. Frontiers in Cell and Developmental Biology. 2024. V. 12. DOI: 10.3389/fcell.2024.1346032
Romanova D., Moroz L.L. Brief History of Placozoa. Methods in Molecular Biology. 2024. V. 2757. P. 103-122. DOI: 10.1007/978-1-0716-3642-8_3
Romanova D., Varoqueaux F., Eitel M., Yoshida M.A., Nikitin M.A., Moroz L.L. Long-Term Culturing of Placozoans (Trichoplax and Hoilungia). Methods in Molecular Biology. 2024. V. 2757. P. 509-529. DOI: 10.1007/978-1-0716-3642-8_21
Anikin A., Aseyev N.A., Johansson N. Do some languages sound more beautiful than others?. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2023. V. 120. N. 17. e2218367120. DOI: 10.1073/pnas.2218367120
Aseyev N., Ivanova V., Balaban P., Nikitin E. Current Practice in Using Voltage Imaging to Record Fast Neuronal Activity: Successful Examples from Invertebrate to Mammalian Studies. Biosensors. 2023. V. 13. N. 6. P. 648. DOI: 10.3390/bios13060648
Aseyev N.A. Perception of color in primates: A conceptual color neurons hypothesis. Bio Systems. 2023. V. 225. P. 104867. DOI: 10.1016/j.biosystems.2023.104867
Borodinova A., Ierusalimsky V., Balaban P. Comparison of the Transduction Capacity of AAV5 and AAV PHP.eB Serotypes in Hippocampus Astroglia. Neuroglia. 2023. V. 4. N. 4. P. 275-289. DOI: 10.3390/neuroglia4040019
Moroz L.L., Mukherjee K., Romanova D. Nitric oxide signaling in ctenophores. Frontiers In Neuroscience. 2023. V. 17. P. 1125433. DOI: 10.3389/fnins.2023.1125433
Moroz L.L., Romanova D. Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals. Animal Cognition. 2023. P. 1-14. DOI: 10.1007/s10071-023-01833-7
Moroz L.L., Romanova D. Homologous vs. Homocratic Neurons: Revisiting Complex Evolutionary Trajectories. Frontiers in Cell and Developmental Biology. 2023. V. 11. P. 1336093. DOI: 10.3389/fcell.2023.1336093
Nikitin E.S., Postnikova T.Y., Proskurina E.Y., Borodinova A.A., Ivanova V.O., Roshchin M.V., Smirnova G.R., Kelmanson I., Belousov V.V., Balaban P.M., Zaitsev A.V. Overexpression of KCNN4 channels in principal neurons produces an anti-seizure effect without reducing their coding ability. Gene Therapy. 2023. DOI: 10.1038/s41434-023-00427-9
Nikitin M.A., Romanova D., Borman S.I., Moroz L.L. Amino acids integrate behaviors in nerveless placozoans. Frontiers In Neuroscience. 2023. V. 17. P. 1125624. DOI: 10.3389/fnins.2023.1125624
Talantseva O.I., Portnova G.V., Romanova D.Y., Martynova O.V., Sysoeva O.V., Grigorenko E.L. Does the Potocki-Lupski Syndrome Convey the Autism Spectrum Disorder Phenotype? Case Report and Scoping Review. Journal Of Personalized Medicine. 2023. V. 13. N. 3. P. 439. DOI: 10.3390/jpm13030439
Aseyev N.A. Morphological and electrophysiological evidences of synaptic switching in vestibular nerve of land snail Helix lucorum L. Biochemical And Biophysical Research Communications. 2022. V. 611. P. 114-117. DOI: 10.1016/j.bbrc.2022.04.026
Ierusalimsky V.N., Balaban P.M., Nikitin E.S. Nav1.6 but not KCa3.1 channels contribute to heterogeneity in coding abilities and dynamics of action potentials in the L5 neocortical pyramidal neurons. Biochemical And Biophysical Research Communications. 2022. V. 615. P. 102-108. DOI: 10.1016/j.bbrc.2022.05.050
Kost L.A., Iunusova V.A., Ivanova V.O., Nikitin E.S., Lukyanov K.A., Bogdanov A.M. The Electromotive Protein Prestin as a Sensitive Core of the Fluorescent Voltage Indicator. Russian Journal of Bioorganic Chemistry. 2022. V. 48. N. 3. P. 617-620. DOI: 10.1134/S1068162022030098
Maltsev A.V., Roshchin M.V., Bezprozvanny I., Smirnov I.V., Vlasova O., Balaban P.M., Borodinova A.A. Bidirectional regulation by "star forces": Ionotropic astrocyte's optical stimulation suppresses synaptic plasticity, metabotropic one strikes back. Hippocampus. 2022. V. 33. N. 1. P. 18-36. DOI: 10.1002/hipo.23486
Moroz L.L., Romanova D. Alternative neural systems: What is a neuron? (Ctenophores, sponges and placozoans). Frontiers In Cell And Developmental Biology. 2022. V. 10. P. 1071961. DOI: 10.3389/fcell.2022.1071961
Nikitin E.S., Roshchin M.V., Borodinova A.A., Zuzina A.B., Balaban P.M. EMPLOYMENT OF OPTICAL PROBES FOR THE IMAGING OF INTRACELLULAR CALCIUM AND ACTION POTENTIAL IN NEURONS. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2022. V. 72. N. 2. P. 149-158. DOI: 10.31857/S0044467722010075
Romanova D., Nikitin M.A., Shchenkov S.V., Moroz L.L. Expanding of Life Strategies in Placozoa: Insights From Long-Term Culturing of Trichoplax and Hoilungia. Frontiers In Cell And Developmental Biology. 2022. V. 10. P. 823283. DOI: 10.3389/fcell.2022.823283
Romanova D.Y., Balaban P.M., Nikitin E.S. Sodium Channels Involved in the Initiation of Action Potentials in Invertebrate and Mammalian Neurons . Biophysica. 2022. V. 2. N. 3. P. 184-193. DOI: 10.3390/biophysica2030019
Roshchina M.A., Borodinova A.A., Roshchin M.V. Influence of histone deacetylases inhibitor sodium butyrate on hippocampal neuronal activity in vivo. Neuroscience and Behavioral Physiology. 2022. V. 52. 769–777. DOI: 10.1007/s11055-022-01240-4
Simonova N.A., Volgushev M.A., Malyshev A.Y. Enhanced Non-Associative Long-Term Potentiation in Immature Granule Cells in the Dentate Gyrus of Adult Rats. Frontiers In Synaptic Neuroscience. 2022. V. 14. P. 889947. DOI: 10.3389/fnsyn.2022.889947
Smirnova G.R., Medvedeva T.M., Pavlova I.V., Vinogradova L.V. Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization. Biomedicines. 2022. V. 10. N. 9. P. 2183. DOI: 10.3390/biomedicines10092183
Borodinova A.A., Balaban P.M., Bezprozvanny I.B., Salmina A.B., Vlasova O.L. Genetic Constructs for the Control of Astrocytes' Activit. Cells. 2021. V. 10. N. 7. P. 1600. DOI: 10.3390/cells10071600
Chasse R., Malyshev A.Y., Fitch R.H., Volgushev M.A. Altered Heterosynaptic Plasticity Impairs Visual Discrimination Learning in Adenosine A1 Receptor Knock-Out Mice. The Journal Of Neuroscience. 2021. V. 41. N. 21. P. 4631-4640. DOI: 10.1523/JNEUROSCI.3073-20.2021
Gerasimov E., Erofeev A., Borodinova A.A., Bolshakova A., Balaban P.M., Bezprozvanny I., Vlasova O.L. Optogenetic Activation of Astrocytes-Effects on Neuronal Network Function. International Journal Of Molecular Sciences. 2021. V. 22. N. 17. P. 9613. DOI: 10.3390/ijms22179613
Gyori J., Kohn A.B., Romanova D., Moroz L.L. ATP signaling in the integrative neural center of Aplysia californica. Scientific Reports. 2021. V. 11. N. 1. P. 5478. DOI: 10.1038/s41598-021-84981-5
Idzhilova O.S., Roshchin M.V., Smirnova G.R., Malyshev A.Y. Central Targeting of Channelrhodopsin2 by the Motif of Potassium Channel Kv2.1 Can be Altered Due to Overexpression of the Construct. BioNanoScience. 2021. V. 11. N. 2. P. 408-416. DOI: 10.1007/s12668-021-00863-0
Kelmanson I.V., Shokhina A.G., Kotova D.A., Pochechuev M.S., Ivanova V.O., Kostyuk A.I., Panova A.S., Borodinova A.A., Solotenkov M.A., Stepanov E.A., Raevskii R.I., Moshchenko A.A., Pak V.V., Ermakova Y.G., van Belle G.J.C., Tarabykin V., Balaban P.M., Fedotov I.V., Fedotov A.B., Conrad M., Bogeski I., Katschinski D.M., Doeppner T.R., Bahr M., Zheltikov A.M., Belousov V.V., Bilan D.S. In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model. Redox Biology. 2021. V. 48. P. 102178. DOI: 10.1016/j.redox.2021.102178
Kolesov D.V., Ivanova V.O., Sokolinskaya E.L., Kost L.A., Balaban P.M., Lukyanov K.A., Nikitin E.S., Bogdanov A.V. Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity. Molecular Biology Reports. 2021. V. 48. N. 5. P. 4549-4561. DOI: 10.1007/s11033-021-06480-0
Moroz L.L., Nikitin M.A., Policar P.G., Kohn A.B., Romanova D. Evolution of glutamatergic signaling and synapses. Neuropharmacology. 2021. V. 199. P. 108740. DOI: 10.1016/j.neuropharm.2021.108740
Moroz L.L., Romanova D. Selective Advantages of Synapses in Evolution. Frontiers In Cell And Developmental Biology. 2021. V. 9. P. 726563. DOI: 10.3389/fcell.2021.726563
Moroz L.L., Romanova D., Kohn A.B. Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters. Philosophical Transactions Of The Royal Society Of London. Series B, Biological Sciences. 2021. V. 376. N. 1821. P. 20190762. DOI: 10.1098/rstb.2019.0762
Nikitin E.S., Vinogradova L.V. Potassium channels as prominent targets and tools for the treatment of epilepsy. Expert Opinion On Therapeutic Targets. 2021. V. 6. P. 1-13. DOI: 10.1080/14728222.2021.1908263
Polinski J.M., Zimin A.V., Clark K.F., Kohn A.B., Sadowski N., Timp W., Ptitsyn A., Khanna P., Romanova D., Williams P., Greenwood S.J., Moroz L.L., Walt D.R., Bodnar A.G. The American lobster genome reveals insights on longevity, neural, and immune adaptations. Science Advances. 2021. V. 7. N. 26. eabe8290. DOI: 10.1126/sciadv.abe8290
Romanova D., Varoqueaux F., Daraspe J., Nikitin M.A., Eitel M., Fasshauer D., Moroz L.L. Hidden cell diversity in Placozoa: ultrastructural insights from Hoilungia hongkongensis. Cell And Tissue Research. 2021. V. 385. N. 3. P. 623-637. DOI: 10.1007/s00441-021-03459-y
Roshchina M.A., Smirnov I.V., Isaev A.B., Roshchin M., Borodinova A.A., Aseyev N.A., Balaban P.M. Investigation of ca1 neuronal activity during context fear conditioning with miniature fluorescence microscopes. Opera Medica et Physiologica. 2021. V. 8. N. 3. P. 52-58. DOI: 10.24412/2500-2295-2021-3-52-58
Borodinova A.A., Balaban P.M. Epigenetic regulation as a basis for long-term changes in the nervous system: in search of specificity mechanisms. Biochemistry (Moscow). 2020. V. 85. N. 9. P. 1139-1158. DOI: 10.31857/S0320972520090018
Ermakova Y.G., Roshchin M.V., Lanin A.A., Balaban P.M., Zheltikov A.M., Belousov V.V., Nikitin E.S. THERMOGENETICS AS A NEW METHOD TO CONTROL NEURONAL ACTIVITY. ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI IP PAVLOVA. 2020. V. 70. N. 1. P. 133-140. DOI: 10.31857/S0044467720010050
Balaban P.M., Borodinova A.A. Neurogenetic Technologies for Research on the Mechanisms Maintaining Memory. Neuroscience and Behavioral Physiology. 2020. V. 50. N. 8. P. 1057-1064. DOI: 10.1007/s11055-020-01005-x
Borodinova A.A., Balaban P.M. Epigenetic Regulation as a Basis for Long-Term Changes in the Nervous System: In Search of Specificity Mechanisms. Biochemistry (Moscow). 2020. V. 85. N. 9. P. 994-1010. DOI: 10.1134/S0006297920090023
Ivanova V.O., Bal N.V., Balaban P.M. Modulation of AMPA receptors by nitric oxide in nerve cells. International Journal of Molecular Sciences. 2020. V. 21. N. 3. DOI: 10.3390/ijms21030981
Malyshev A.Y., Ostrovsky M.A. Experience in the Use of Optogenetic Approaches to Studies of Brain Functions and Prosthetization of Degenerative Retinas. Neuroscience and Behavioral Physiology. 2020. V. 50. N. 8. P. 1065-1071. DOI: 10.1007/s11055-020-01006-w
Moroz L.L., Romanova D., Nikitin M.A., Sohn D., Kohn A.B., Neveu E., Varoqueaux F., Fasshauer D. The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission. Scientific Reports. 2020. V. 10. N. 1. P. 13020. DOI: 10.1038/s41598-020-69851-w
Moroz L.L., Sohn D., Romanova D., Kohn A.B. Microchemical identification of enantiomers in early-branching animals: Lineage-specific diversification in the usage of D-glutamate and D-aspartate. Biochemical And Biophysical Research Communications. 2020. V. 527. N. 4. P. 947-952. DOI: 10.1016/j.bbrc.2020.04.135