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Mikhail Yu. Stepanichev

Leading Scientist, D.Sc. in Biology

brain, aging, Alzheimer's disease, neurodegeneration, learning, memory, neurotrophic factors, neuroplasticity, stress, epilepsy, depression, oxidative stress, free radicals, nitric oxide

Laboratory of Functional Biochemistry of the Nervous System
Scopus ID
6701546567
ORCID ID
0000-0001-8109-8692
Web of Science ResearcherID
J-8022-2018
SPIN code
1669-4477

Undergraduate                       Chemistry and Biology

Leo Tolstoy’s State Pedagogical Institute, Tula (1985-1990)

                                   Title: “Spectral behavior of sigma-complexes in different solvents”

                                   Supervisors: Dr. T. Golopolosova (Chemistry)

                                                        Dr. E. Alifanova (Chemistry)

 

PhD                            Dept. Functional Biochemistry of the Nervous System,

                                   Institute of Higher Nervous Activity & Neurophysiology 

                                   Russian Academy of Sciences (1992-1997)

                                   Title: “Neurochemical correlates of individual behavior in rats”

                                   Supervisor: Prof. N. Gulyaeva (Physiology)

 

DSci                           Dept. Functional Biochemistry of the Nervous System,

                                   Institute of Higher Nervous Activity & Neurophysiology 

                                   Russian Academy of Sciences (2010)

Title: “Behavioral impairments and structural-functional changes in rat brain during modeling of neurodegeneration”

 

 

Post-D                         Dept. Functional Biochemistry of the Nervous System,

                                   Institute of Higher Nervous Activity & Neurophysiology 

                                   Russian Academy of Sciences (2011-pres.)

 

Publication list

Papers

  • Stepanichev M.Y., Kudryashova I.V., Yakovlev A.A., Onufriev M.V., Khaspekov L.G., Lyzhin A.A., Lazareva N.A., Gulyaeva N.V. Central administration of a caspase inhibitor impairs shuttle-box performance in rats. Neuroscience. 2005. V. 136. N. 2. P. 579-591. DOI: 10.1016/j.neuroscience.2005.08.010
  • Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Gulyaeva N.V. Studies of the effects of fragment (25-35) of beta-amyloid peptide on the behavior of rats in a radial maze. Neuroscience and Behavioral Physiology. 2005. V. 35. N. 5. P. 511-518. DOI: 10.1007/s11055-005-0086-1
  • Zarubenko I.I., Yakovlev A.A., Stepanichev M.Y., Gulyaeva N.V. Electroconvulsive shock induces neuron death in the mouse hippocampus: Correlation of neurodegeneration with convulsive activity. Neuroscience and Behavioral Physiology. 2005. V. 35. N. 7. P. 715-721. DOI: 10.1007/s11055-005-0115-0
  • Pavlova T.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritskii A.M., Gulyaeva N.V. Pentylenetetrazole kindling induces activation of caspase-3 in the rat brain. Neuroscience and Behavioral Physiology. 2004. V. 34. N. 1. P. 45-47. DOI: 10.1023/B:NEAB.0000003246.26997.10
  • Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Amyloid-β(25-35)-induced memory impairments correlate with cell loss in rat hippocampus. Physiology and Behavior. 2004. V. 80. N. 5. P. 647-655. DOI: 10.1016/j.physbeh.2003.11.003
  • Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Amyloid-β(25-35)-induced memory impairments correlate with cell loss in rat hippocampus. Physiology and Behavior. 2004. V. 80. N. 5. P. 647-655. DOI: 10.1016/j.physbeh.2003.11.003
  • Pavlova I.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritsky A.M., Gulyaeva N.V. Pentylenetetrazole kindling induces activation of caspase-3 in the rat brain. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2003. V. 53. P. 110-113.
  • Egorova L.K., Stepanichev M.Y., Mikhalev S.L., Kutepova O.A., Gulyaeva N.V. Analysis of cyclic adenosine-3′,5′-monophosphate levels in structures of the "Informational" and "Motivational" systems of the rat brain during acquistion of a conditioned active avoidance reaction. Neuroscience and Behavioral Physiology. 2003. V. 33. N. 4. P. 329-333. DOI: 10.1023/A:1022887321863
  • Gulyaeva N.V., Thompson C., Shinohara N., Lazareva N.A., Onufriev M.V., Stepanichev M.Y., Moiseeva Y.V., Fliss H., Hakim A.M. Tongue protrusion: A simple test for neurological recovery in rats following focal cerebral ischemia. Journal of Neuroscience Methods. 2003. V. 125. N. 1-2. P. 183-193. DOI: 10.1016/S0165-0270(03)00056-6
  • Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Single intracerebroventricular administration of amyloid-beta (25-35) peptide induces impairment in short-term rather than long-term memory in rats. Brain Research Bulletin. 2003. V. 61. N. 2. P. 197-205. DOI: 10.1016/S0361-9230(03)00118-7
  • Stepanichev M.Y., Zdobnova I.M., Yakovlev A.A., Onufriev M.V., Lazareva N.A., Zarubenko I.I., Gulyaeva N.V. Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35). Journal of Neuroscience Research. 2003. V. 71. N. 1. P. 110-120. DOI: 10.1002/jnr.10469
  • Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Administration of aggregated beta-amyloid peptide (25-35) induces changes in long-term potentiation in the hippocampus in vivo. Neuroscience and behavioral physiology. 2003. V. 33. N. 2. P. 95-98. DOI: 10.1023/A:1021761310435
  • Egorova L.K., Stepanichev M.Y., Mikhalev S.L., Kutepova O.A., Gulyaeva N.V. Analysis of cyclic adenosine-3',5'-monophosphate levels in structures of the "informational" and "motivational" systems of the rat brain during acquisition of a conditioned active avoidance reaction. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2002. V. 52. P. 235-240.
  • Zdobnova I.M., Stepanichev M.Y., Yakovlev A.A., Onufriev M.V., Egorova L.K., Moiseeva Y.V., Lazareva N.A., Matz V.N., Gulyaeva N.V. The interaction of the neurotoxic fragment of the beta-amyloid peptide and tumor necrosis factor alpha with intracerebral administration to rats. Nejrokhimija. 2002. V. 19. P. 117-122.
  • Pavlova I.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritsky A.M., Gulyaeva N.V. Pentylenetetrazole Kindling causes oxidative stress in rat brain. Nejrokhimija. 2002. V. 19. P. 123-126.
  • Stepanichev M.Y., Moiseeva Y.V., Gulyaeva N.V. "Injection" models of Alzheimer's disease: oxidative stress in the toxicity mechanism of AF64A and β-amyloid peptide in rodents. Nejrokhimija. 2002. V. 19. P. 165-175.
  • Bolshakov A.P., Onufriev M.V., Khanicheva N.A., Stepanichev M.Y., Chabak-Garbach R.., Ajrapetiantz M.G., Gulyaeva N.V. Effect of early social isolation on nitric oxide synthase activity in rat brain. Nejrokhimija. 2001. V. 18. P. 262-266.
  • Moiseeva Y.V., Onufriev M.V., Lazareva N.A., Stepanichev M.Y., Gulyaeva N.V. Free-radical mechanisms of septo-hippocampal neurodegeneration caused by cholinotoxin AF64A in rats in vivo. Nejrokhimija. 2001. V. 18. P. 287-289.
  • Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Administration of aggregated beta-amyloid peptide (25-35) causes change in long-term potentiation in the hippocampus. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2001. V. 51. N. 6. P. 690-693.
  • Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Increase in activity of NO-synthetase in rat's hippocampus follows long-term potentiation in vivo. Nejrokhimiya. 2001. V. 18. N. 1. P. 55-61.
  • Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Administration of aggregated beta-amyloid peptide (25-35) induces changes in long-term potentiation in hippocampus in vivo. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2001. V. 51. N. 6. P. 701-704.
  • Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Increased NO synthase activity in rat hippocampus accompanies prolonged in vivo potentiation. Nejrokhimija. 2001. V. 18. P. 55-61.
  • Tsubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Administration of aggregated beta-amyloid peptide (25–35) induces changes in long-term potentiation in the hippocampus in vivo. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2001. V. 51. P. 701-704.
  • Yakovlev A.A., Onufriev M.V., Stepanichev M.Y., Braun K.., Gulyaeva N.V. Caspase-3 activity in different parts of the brain of rodents. Nejrokhimija. 2001. V. 18. P. 41-43.
  • Yakovlev A.A., Onufriev M.V., Stepanichev M.Y., Gulyaeva N.V. The effect of pentylenetetrazole on caspase-3 activity in the brain regions of mice. Nejrokhimija. 2001. V. 18. P. 191-194.
  • Stepanichev M.Y., Onufriev M.V., Bock J., Gulyaeva N.V., Poeggel G., Braun K. Changes of nitric oxide synthase activity in response to different levels of social separation in two day old domestic chicks (Gallus gallus domesticus). Neuroscience Research Communications. 2000. V. 27. P. 175-181.
  • Stepanichev M.Y., Onufriev M.V., Mitrokhina O.S., Moiseeva Y.V., Lazareva N.A., Victorov I.V., Gulyaeva N.V. Neurochemical, behavioral, and neuromorphological effects of central administration of beta-amyloid peptide (25-35) in rat. Nejrokhimija. 2000. V. 17. P. 278-290.
  • Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Lazareva N.A., Onufriev M.V., Moiseeva Y.V., Chernyavskaya L.I., Gulyaeva N.V. Seizure intensity correlates with oxidative stress and apoptosis in the hippocampus in the kainic acid model in rat. Nejrokhimija. 2000. V. 17. P. 189-191.
  • Mitrokhina O.S., Stepanichev M.Y., Lazareva N.A., Moiseeva Y.V., Onufriev M.V., Gulyaeva N.V. The effect of intracerebroventricular administration of a fragment (25-35) of beta-amyloid peptide on lipid peroxidation in rat brain and blood. Doklady Akademii Nauk. 1999. V. 368. P. 711-713.
  • Moiseeva Y.V., Egorova L.K., Onufriev M.V., Mitrokhina O.S., Lazareva N.A., Stepanichev M.Y., Gulyaeva N.V. NO synthase activity and indicators of free radical oxidation in the brain regions of Wistar rats resistant and prone to audiogenic epilepsy: effects of immobilization stress. Nejrokhimija. 1999. V. 16. P. 54-61.
  • Onufriev M.V., Stepanichev M.Y., Mitrokhina O.S., Moiseeva Y.V., Lazareva N.A., Gulyaeva N.V. The effect of oxidative stress on the activity of nitric oxide synthase in vivo and in vitro. Rossijskoj Fiziologicheskij Zhurnal. 1999. V. 85. P. 531-538.
  • Rozhnova U.A., Stepanichev M.Y., Korobko V.G., Gulyaeva N.V., Alesenko A.V. Activation of the sphingomoelin cycle and cholesterol accumulation in rat cortex, hippocampus and cerebellum under the action of tumor necrosis factor alpha. Nejrokhimija. 1999. V. 16. 118-131.
  • Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Zarzhetsky Y.V., Mutuskina E.A., Gurvich A.M., Gulyaeva N.V. Delayed effects of systemic circulatory arrest on free radical processes in the brain structures of rats with different types of behavior in the emotional resonance test. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1999. V. 49. P. 653-663.
  • Stepanichev M.Y., Lazareva N.A., Onufriev M.V., Mitrokhina O.S., Moiseeva Y.V., Gulyaeva N.V. Effects of doses of fragment (25-35) of β-amyloid peptide on behavior in rats. Neuroscience and Behavioral Physiology. 1998. V. 28. N. 5. P. 564-566. DOI: 10.1007/BF02463018
  • Gulyaeva N.V., Stepanichev M.Y. Biochemical correlates of individual behavior. Neuroscience and Behavioral Physiology. 1997. V. 27. N. 4. P. 462-469. DOI: 10.1007/BF02462948
  • Gurvitch A.M., Mutuskina E.A., Zarzhetsky Y.V., Trubina I.E., Avruschenko M.S., Pylova S.I., Volkov A.V., Lazareva N.A., Stepanichev M.Y., Onufriev M.V., Gulyaeva N.V. Prophylaxis of encephalopathies and risk factors of atherogenesis development in the postresuscitation period in rats by means of succinic acid. Resuscitation. 1997. V. 35. N. 2. P. 165-170. DOI: 10.1016/S0300-9572(97)00045-2
  • Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Zazhetsky Y.V., Mutuskina E.A., Gutvitch A.M., Gulyaeva N.V. Postresuscitation changes in brain free radical-mediated processes and nitric oxide synthase activity in rats: effects of individual behavior in "emotional resonance" test. Neurochemical Research. 1997. V. 22. N. 6. P. 743-752.
  • Gulyaeva N.V., Lazareva N.A., Libe M.L., Mitrokhina O.S., Onufriev M.V., Stepanichev M.Y., Chernysevskaya I.A., Walsh T.J. Oxidative stress in the brain following intraventricular administration of ethylcholine aziridinium (AF64A). Brain Research. 1996. V. 726. N. 1-2. P. 174-180. DOI: 10.1016/0006-8993(96)00330-7
  • Gulyaeva N.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Zarzhetsky Y.V., Gurvitch A.M., Volkov A.V. Cardiac arrest induces decrease of nitric oxide synthase activity and increase of free radical generation in rat brain regions. Neuroscience Letters. 1996. V. 220. N. 3. P. 147-150. DOI: 10.1016/S0304-3940(96)13250-X
  • Gulyaeva N.V., Onufriev M.V., Stepanichev M.Y. No synthase and free radical generation in brain regions of old rats: Correlations with individual behaviour. NeuroReport. 1994. V. 6. N. 1. P. 94-96. DOI: 10.1097/00001756-199412300-00025