Laboratory of Neuroontogenesis

Brief history of the laboratory

The laboratory of neuroontogenesis was formed in 1989 and belongs to the scientific school of academician Peter Kuzmich Anokhin. The laboratory develops ideas about system genesis, developmental heterochronies and functional systems. Her origins are Kira Vasilyevna Shuleykina and Sergey Naumovich Khayutin. Laboratory research aims to solve the following problems: · the role of environmental factors (afferent influx) in the formation of the structure and functions of the developing brain. · The study of the role of early sensory experience in the formation of memory and learning of adult animals. · The study of the structural and functional bases of the formation of early forms of behavior and the modification of their sensory support in the subsequent stages of postnatal ontogenesis. · Study of integrative interactions in the nervous system during normal ontogenesis, under conditions of restriction of sensory input and with genetically determined developmental disorders.

Список сотрудников

Publication list

Papers

Rebik A.A., Broshevitskaya N., Kuzhuget S., Aleksandrov P., Abbasova K., Zaichenko M.I., Midzyanovskaya I.S. Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky–Molodkina Rats. Biomedicines. 2023. N. 11. P. 2566. DOI: 10.3390/biomedicines11092566
Neklyudova A.K., Smirnov K.S., Rebreikina A.B., Martynova O.V., Sysoeva O.V. Electrophysiological and Behavioral Evidence for Hyper- and Hyposensitivity in Rare Genetic Syndromes Associated with Autism. Genes. 2022. V. 13. N. 4. P. 671. DOI: 10.3390/genes13040671
Rebik A.A., Riga V.D., Smirnov K.S., Sysoeva O.V., Midzyanovskaya I.S. Social Behavioral Deficits in Krushinsky-Molodkina Rats, an Animal Model of Audiogenic Epilepsy. Journal Of Personalized Medicine. 2022. V. 12. N. 12. P. 2062. DOI: 10.3390/jpm12122062
Korneeva E.V., Tiunova A.A., Alexandrov L.I., Golubeva T.B. Influence of Natural Asymmetric Embryonic Visual Afferentation on the Neuronal Activations in the Caudomedial Mesopallium during the Freezing Response in Altricial Nestlings. Doklady Biological Sciences. 2021. V. 497. N. 1. P. 62-64. DOI: 10.1134/S0012496621020046
Levichkina E.V., Busygina I.I., Pigareva M.L., Pigarev I.N. The Mysterious Island: Insula and Its Dual Function in Sleep and Wakefulness. Frontiers In Systems Neuroscience. 2021. V. 14. P. 592660. DOI: 10.3389/fnsys.2020.592660
Sitnikova E.Y., Rutskova E.M., Tsvetaeva D., Raevsky V.V. Spike-wave seizures, slow-wave sleep EEG and morphology of substantia nigra pars compacta in WAG/Rij rats with genetic predisposition to absence epilepsy. Brain Research Bulletin. 2021. V. 174. P. 63-71. DOI: 10.1016/j.brainresbull.2021.06.003
Sitnikova E.Y., Smirnov K.S., Raevsky V.V. Sensory Inflow from Whiskers Modulates Development of Absence Epilepsy in WAG/Rij Rats. Advances in Intelligent Systems and Computing. 2021. V. 1358 AIST. P. 510-519. DOI: 10.1007/978-3-030-71637-0_59
Smirnov K.S., Stroganova T., Molholm S., Sysoeva O.V. Reviewing Evidence for the Relationship of EEG Abnormalities and RTT Phenotype Paralleled by Insights from Animal Studies. International Journal Of Molecular Sciences. 2021. V. 22. N. 10. P. 5308. DOI: 10.3390/ijms22105308
Midzyanovskaya I.S., Petrenko N.E., Biryukova L.M., Tuomisto L.M. Reduced H3 histamine receptor binding densities in the upper layers of motor cortex in rats prone to audiogenic convulsive seizures. Epilepsy Research. 2020. V. 170. P. 106543. DOI: 10.1016/j.eplepsyres.2020.106543
Pigarev I.N., Pigareva M.L., Levichkina E.V. Probable Mechanism of Antiepileptic Effect of the Vagus Nerve Stimulation in the Context of the Recent Results in Sleep Research. Frontiers In Neuroscience. 2020. V. 14. P. 160. DOI: 10.3389/fnins.2020.00160
Romanova D.Y., Smirnov K.S., Nikitin M.A., Kohn A.B., Borman A.I., Malyshev A.Y., Balaban P.M., Moroz L.L. Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals. Biochemical And Biophysical Research Communications. 2020. V. 532. N. 1. P. 120-126. DOI: 10.1016/j.bbrc.2020.08.020
Sharova E.V., Kotovich Ju.V., Deza-Araujo Y.I., Smirnov K.S., Gavron A.A., Fadeeva L.M., Chelyapina-Postnikova M.V., Alexandrova E.V., Vronkova L.A., Boldyreva G.N., Verkhlyutov V.M., Kornienko V.N., Pronin I.N. fMRI resting state networks visualization in patients with severe traumatic brain injury. Medical Visualization. 2020. V. 24. N. 1. P. 68-84. DOI: 10.24835/1607-0763-2020-1-68-84
Pigarev I., Pigareva M.L. Progress in Sleep Studies in the Epoch of Electrophysiology. The Visceral Theory of Sleep. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 7. P. 903-909. DOI: 10.1007/s11055-019-00817-w
Pigarev I.N., Pigareva M.L., Levichkina E.V. On the mechanism of therapeutic effects of electrostimulation. Interpretations and predictions based on the results of sleep studies. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2019. V. 119. N. 4. P. 15-21. DOI: 10.17116/jnevro201911904215
Sysoeva O.V., Smirnov K., Stroganova T.A. Sensory evoked potentials in patients with Rett syndrome through the lens of animal studies: Systematic review. Clinical Neurophysiology. 2019. V. 131. N. 1. P. 213-224. DOI: 10.1016/j.clinph.2019.11.003
Tsvetaeva D.A., Sitnikova E.Y., Raevsky V.V. Cortical Somatosensory Neurons in WAG/Rij Rats Transform Firing Evoked by Simulation of Posterior Thalamic Nucleus from Tonic to Phasic at Age of 6 Months. Bulletin Of Experimental Biology And Medicine. 2019. V. 168. N. 1. P. 1-4. DOI: 10.1007/s10517-019-04632-8
Shishelova A.Y., Raevsky V.V. The influence of pre- and postnatal factors on the formation of early behavioral reactions. Doklady Akademii Nauk. 2018. V. 479. N. 3. P. 351-353. DOI: 10.7868/S0869565218090268
Pigarev I.N., Pigareva M.L. Progress of sleep studies in the age of electrophysiology. The visceral theory of sleep. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2018. V. 118. N. 4. P. 5-13. DOI: 10.17116/jnevro2018118425
Pigarev I.N., Pigareva M.L. Therapeutic Effects of Electrical Stimulation: Interpretations and Predictions Based on the Visceral Theory of Sleep. Frontiers In Neuroscience. 2018. V. 12. P. 65. DOI: 10.3389/fnins.2018.00065
Tsvetayeva D.A., Sitnikova E.Y., Raevsky V.V. The Responses of Neurons of the Somatosensory Cortex to Stimulation of the Posterior Thalamus (PO) in WAG/Rij Rats Genetically Predisposed to Absence Epilepsy. Doklady Biological Sciences. 2018. V. 480. N. 1. P. 75-77. DOI: 10.1134/S0012496618030109
Pigarev I., Pigareva M.L. Association of sleep impairments and gastrointestinal disorders in the context of the visceral theory of sleep. Journal of Integrative Neuroscience. 2017. V. 16. N. 2. P. 143-156. DOI: 10.3233/JIN-170005
Pigarev I.N., Pigareva M.L. Long and difficult way towards the understanding of sleep function. Period before the age of electrophysiology. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2017. V. 117. N. 4 Special Issue 2. P. 91-97. DOI: 10.17116/jnevro20171174291-97
Biryukova L.M., Sitnikova E.Y., Kulikov M.A., Raevsky V.V. Compensatory Changes in the Brain Dopaminergic System of WAG/Rij Rats Genetically Predisposed to Absence Epilepsy. Bulletin of Experimental Biology and Medicine. 2016. V. 161. N. 5. P. 662-665. DOI: 10.1007/s10517-016-3480-5
Shishelova A.Y., Aliev R.R., Raevsky V.V. The influence of early sensory experience on the research activity of adult animals. Doklady Akademii Nauk. 2016. V. 468. N. 1. P. 1-3. DOI: 10.7868/S0869565216130272
Korneeva E.V., Tiunova A.A., Alexandrov L.I., Golubeva T.B. Wulst activation in pied flycatcher nestlings in feeding behavior induced by patterned visual stimulus. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2016. V. 66. N. 1. P. 74-81. DOI: 10.7868/S0044467716010081
Midzyanovskaya I.S., Biryukova L.M., Shatskova A.B., van Luijtelaar G., Tuomisto L.M. H1 histamine receptor densities are increased in brain regions of rats with genetically generalized epilepsies. Epilepsy Research. 2016. V. 127. P. 135-140. DOI: 10.1016/j.eplepsyres.2016.08.029
Sitnikova E.Y., Rutskova E.M., Raevsky V.V. Maternal care affects EEG properties of spike-wave seizures (including pre- and post ictal periods) in adult WAG/Rij rats with genetic predisposition to absence epilepsy. Brain Research Bulletin. 2016. V. 127. P. 84-91. DOI: 10.1016/j.brainresbull.2016.08.019
Pigarev I.N., Pigareva M.L. The state of sleep and the current brain paradigm. Frontiers In Systems Neuroscience. 2015. V. 9. P. 139. DOI: 10.3389/fnsys.2015.00139
Sitnikova E.Y., Rutskova E.M., Raevsky V.V. Reduction of epileptic spike-wave activity in WAG/Rij rats fostered by Wistar dams. Brain Research. 2015. V. 1594. P. 305-9. DOI: 10.1016/j.brainres.2014.10.067
Korneeva E.V., Alexandrov L.I., Hramov A.E., Sitnikova E.Y., Raevsky V.V. EEG in Altricial Pied Flycatcher Nestlings During the Functional Sates Related with Natural Behavior Cycle. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2014. V. 64. N. 2. P. 208-217. DOI: 10.7868/S0044467714020105
Sarkisova K.Y., Kulikov M.A., Kudrin V.S., Midzyanovskaya I.S., Biryukova L.M. Age-related changes in behavior, in monoamines and their metabolites content, and in density of Dl and D2 dopamine receptors in the brain structures of WAG/Rij rats with depression-like pathology. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2014. V. 64. N. 6. P. 668-685. DOI: 10.7868/S0044467714060094
Korneeva E.V., Tiunova A.A., Alexandrov L.I., Golubeva T.B., Anokhin K.V. Visual input affects the expression of the early genes C-Fos and ZENK in auditory telencephalie centers of pied flycatcher nestlings during the acoustically-guided freezing. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2014. V. 64. N. 3. P. 324-333. DOI: 10.7868/S0044467714030071
Pigarev I.N., Pigareva M.L. Partial sleep in the context of augmentation of brain function. Frontiers In Systems Neuroscience. 2014. V. 8. P. 75. DOI: 10.3389/fnsys.2014.00075
Sarkisova K.Y., Kulikov M.A., Kudrin V.S., Narkevich V.B., Midzyanovskaya I.S., Biryukova E.V., Folomkina A.A., Bazyan A.S. Neurochemical mechanisms of depression-like behavior in WAG/Rij rats. Zhurnal vyssheǐ nervnoǐ deiatelnosti imeni I P Pavlova. 2013. V. 63. N. 3. P. 303-315. DOI: 10.7868/S0044467713030106
Pigarev I., Pigareva M.L. Sleep, emotions, and visceral control. Human Physiology. 2013. V. 39. N. 6. P. 590-601. DOI: 10.1134/S036211971306008X
Sitnikova E.Y., Egorova T.N., Raevsky V.V. A decrease in the density of neurons in the compact part of the substantia nigra correlates with a low peak wave activity in WAG / Rij rats. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2012. V. 62. N. 5. P. 619-628.
Pigarev I., Pigareva M.L. Sleep and the control of visceral functions. Neuroscience and Behavioral Physiology. 2012. V. 42. N. 9. P. 948-956. DOI: 10.1007/s11055-012-9661-4
Samotaeva I.S., Biryukova L.M., Midzyanovskaya I.S., Kuznetsova M.A., Bazyan A.S., Tuomisto L. Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats. Epilepsy Research. 2012. V. 101. N. 1-2. P. 148-56. DOI: 10.1016/j.eplepsyres.2012.03.016
Pigarev I.N., Fedorov G.O., Levichkina E.V., Marimon J.M., Pigareva M.L., Almirall H. Visually triggered K-complexes: a study in New Zealand rabbits. Experimental Brain Research. 2011. V. 210. N. 1. P. 131-42. DOI: 10.1007/s00221-011-2606-2
Sitnikova E.Y., Kulikova S., Birioukova L., Raevsky V.V. Cellular neuropathology of absence epilepsy in the neocortex: a population of glial cells rather than neurons is impaired in genetic rat model. Acta Neurobiol Exp (Wars). 2011. V. 71. N. 2. P. 263-268.
Korneeva E.V., Tiunova A.A., Alexandrov L.I., Golubeva T.B., Anokhin A.A. Activation of tectofugal visual system of the pied flycatcher nestlings at early developmental stages of feeding behavior guided by diffuse photosensitivity. Zhurnal Vysshei Nervnoi Deiatelnosti im. I.P.Pavlova. 2010. V. 60. N. 3. P. 330-338.
Korneeva E.V., Aleksandrov L.I., Golubeva T.B., Raevskii V.V. Effects of visual deprivation on the development of auditory sensitivity during formation of the freezing reaction in pied flycatcher nestlings. Neuroscience and Behavioral Physiology. 2010. V. 40. N. 5. P. 479-482. DOI: 10.1007/s11055-010-9284-6
Sitnikova E.Y., Raevsky V.V. The lemniscal and paralemniscal pathways of the trigeminal system in rodents are integrated at the level of the somatosensory cortex. Neuroscience and Behavioral Physiology. 2010. V. 40. N. 3. P. 325-331. DOI: 10.1007/s11055-010-9259-7
Korneeva E.V., Alexandrov L.I., Golubeva T.B., Raevsky V.V. Visual deprivation affects the development of auditory sensitivity during the period of maturation of freezing response in pied flycatcher nestlings. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2009. V. 59. N. 2. P. 180-184.
Kulikova S.N., Sitnikova E.Y., Raevsky V.V. Cytomorphological features of the neocortex in rats with genetic predisposition to absence epilepsy. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2009. V. 59. N. 4. P. 506-512.
Sitnikova E.Y., Raevsky V.V. Lemniscal and paralemniscal afferent pathways in rodents' trigeminal system are integrated at the level of the somatosensory cortex. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2009. V. 59. N. 1. P. 98-106.
Shishelova A.Y., Raevsky V.V. Influence of vibrissectomy in early postnatal ontogeny of rat pups on behavioral development. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2009. V. 59. N. 3. P. 326-334.
Sysoeva O.V., Maluchenko N.V., Smirnov K.S., Shleptsova V.A., Ivanitsky A.M., Tonevitsky A.G. Peculiarities of brain information processing in persons with different serotonin transporter gene variants. Bulletin of Experimental Biology and Medicine. 2009. V. 148. N. 5. P. 731-734. DOI: 10.1007/s10517-010-0803-9
Budilin S.Y., Pasikova N.V., Midzyanovskaya I.S., Ioffe M.E. Effect of apomorphine injection into the nucleus accumbens on the limb preference in manipulation movements in rats. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2008. V. 58. N. 3. P. 339-344.
Budilin S.Y., Midzyanovskaya I.S., Shchegolevskii N.V., Ioffe M.E., Bazyan A.S. Asymmetry in dopamine levels in the nucleus accumbens and motor preference in rats. Neuroscience and Behavioral Physiology. 2008. V. 38. N. 9. P. 991-994. DOI: 10.1007/s11055-008-9082-6