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Evgenia Y. Sitnikova
Leading Scientist, D.Sc. in Biology
neuroontogenesis, somatosensory cortex, thalamo-cortical system, translational neuroscience, absence epilepsy, sleep mechanisms, sleep disorders, sleep spindles, brain rhythms, EEG analysis
Laboratory of NeuroontogenesisE-mail: eu.sitnikova@ihna.ru
- Scopus ID
- 6701547705
- ORCID ID
- 0000-0002-2819-9096
- Web of Science ResearcherID
- B-6313-2018
- SPIN code
- 2483-7691
My primary area of research is translational neuroscience. I am interested in the mechanisms of inherited brain diseases. We use a genetic "in vivo" rat model in our ongoing research. I am also very interested in expanding my research collaborations into interdisciplinary fields with experts in physics, mathematics, and genetics.
My team is a student-run research group that is focused on the following topics:
- Absence-epilepsy in genetically predisposed rats.
- Analysis of electrical brain activity in freely moving rats.
- Studying the epileptic phenotype in WAG/Rij rat model of absence-epilepsy; selection of non-epileptic control substrain (NEW, non-epileptic WAG/Rij rats).
- Studying the associations between absence-epilepsy and neuro-behavioral comorbidities in genetic rat models.
- Studying the thalamo-cortical mechanisms in health and disease.
- Studying the process of sleep and sedation in rats.
- Studying the rats' behavioral skills, social behavior and cognitive abilities (also the analysis of ultrasonic vocalizations).
- Development of new methods and approaches to signals analysis, application of the artificial neuronal networks for automatization of routine EEG analysis.
- Studying adrenergic mechanisms of absence epilepsy, sleep and sedation.
Publication list
Papers
- VanLuijtelaar G., Sitnikova E.Y., Luttjohann A. On the origin and suddenness of absences in genetic absence models. Clinical EEG and Neuroscience. 2011. V. 42. N. 2. P. 83-97. DOI: 10.1177/155005941104200209
- Sitnikova E.Y. The influence of early sensory experience on the formation of the functional properties of neurons in the projection region of vibrissae in the neocortex in rats. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2010. V. 60. N. 6. P. 719-728.
- Sitnikova E.Y. Thalamo-cortical mechanisms of sleep spindles and spike-wave discharges in rat model of absence epilepsy (a review). Epilepsy Research. 2010. V. 89. N. 1. P. 17-26. DOI: 10.1016/j.eplepsyres.2009.09.005
- Sitnikova E.Y., Raevsky V.V. The lemniscal and paralemniscal pathways of the trigeminal system in rodents are integrated at the level of the somatosensory cortex. Neuroscience and Behavioral Physiology. 2010. V. 40. N. 3. P. 325-331. DOI: 10.1007/s11055-010-9259-7
- Kulikova S.N., Sitnikova E.Y., Raevsky V.V. Cytomorphological features of the neocortex in rats with genetic predisposition to absence epilepsy. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2009. V. 59. N. 4. P. 506-512.
- Sitnikova E.Y., Raevsky V.V. Lemniscal and paralemniscal afferent pathways in rodents' trigeminal system are integrated at the level of the somatosensory cortex. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2009. V. 59. N. 1. P. 98-106.
- Sitnikova E.Y., Hramov A.E., Koronovsky A.A., VanLuijtelaar G. Sleep spindles and spike-wave discharges in EEG: Their generic features, similarities and distinctions disclosed with Fourier transform and continuous wavelet analysis. Journal of Neuroscience Methods. 2009. V. 180. N. 2. P. 304-316. DOI: 10.1016/j.jneumeth.2009.04.006
- Sitnikova E.Y., VanLuijtelaar G. Electroencephalographic precursors of spike-wave discharges in a genetic rat model of absence epilepsy: Power spectrum and coherence EEG analyses. Epilepsy Research. 2009. V. 84. N. 2-3. P. 159-171. DOI: 10.1016/j.eplepsyres.2009.01.016
- Sitnikova E.Y., Dikanev T., Smirnov D., Bezruchko B., VanLuijtelaar G. Granger causality: Cortico-thalamic interdependencies during absence seizures in WAG/Rij rats. Journal of Neuroscience Methods. 2008. V. 170. N. 2. P. 245-254. DOI: 10.1016/j.jneumeth.2008.01.017
- Koronovsky A.A., Minukhin I.M., Tyshenko A.A., Khramov A.E., Midzyanovskaya I.S., Sitnikova E.Y., VanLuijtelaar G.., VanRijn C.M. Using continuous wavelet transform to analyze intermittent behavior. Prikladnaja i nelinejnaja dinamika. 2007. V. 15. N. 4. P. 34-54.
- Sargsyan A., Sitnikova E.Y., Melkonyan A., Mkrtchian H., VanLuijtelaar G. Simulation of sleep spindles and spike and wave discharges using a novel method for the calculation of field potentials in rats. Journal of Neuroscience Methods. 2007. V. 164. N. 1. P. 161-176. DOI: 10.1016/j.jneumeth.2007.03.023
- Sitnikova E.Y., VanLuijtelaar G. Electroencephalographic characterization of spike-wave discharges in cortex and thalamus in WAG/Rij rats. Epilepsia. 2007. V. 48. N. 12. P. 2296-2311. DOI: 10.1111/j.1528-1167.2007.01250.x
- Koronovsky A.A., Kuznetsova G.D., Midzyanovskaya I.S., Sitnikova E.Y., Trubetskov D.I., Khramov A.E. Patterns of intermittent behavior in spontaneous non-convulsive convulsive activity in rats. Doklady Akademii Nauk. 2006. V. 409. N. 2. P. 274-276.
- Hramov A., Koronovskii A.A., Midzyanovskaya I.S., Sitnikova E.Y., VanRijn C.M. On-off intermittency in time series of spontaneous paroxysmal activity in rats with genetic absence epilepsy. Chaos. 2006. V. 16. N. 4. P. 043111. DOI: 10.1063/1.2360505
- Sitnikova E.Y., VanLuijtelaar G. Cortical and thalamic coherence during spike-wave seizures in WAG/Rij rats. Epilepsy Research. 2006. V. 71. N. 2-3. P. 159-180. DOI: 10.1016/j.eplepsyres.2006.06.008
- VanLuijtelaar G., Sitnikova E.Y. Global and focal aspects of absence epilepsy: The contribution of genetic models. Neuroscience and Biobehavioral Reviews. 2006. V. 30. N. 7. P. 983-1003. DOI: 10.1016/j.neubiorev.2006.03.002
- Sitnikova E.Y., Raevsky V.V. Morphological basis for compensating sensory deficit in early ontogenesis. Novosti Mediko-Biologicheskikh Nauk. 2005. V. 2. P. 5-11.
- Sitnikova E.Y., Luijtelaar G.V. Reduction of adrenergic neurotransmission with clonidine aggravates spike-wave seizures and alters activity in the cortex and the thalamus in WAG/Rij rats. Brain Research Bulletin. 2005. V. 64. N. 6. P. 533-540. DOI: 10.1016/j.brainresbull.2004.11.004
- Sitnikova E.Y., VanLuijtelaar G. Cortical control of generalized absence seizures: Effect of lidocaine applied to the somatosensory cortex in WAG/Rij rats. Brain Research. 2004. V. 1012. N. 1-2. P. 127-137. DOI: 10.1016/j.brainres.2004.03.041
- Sitnikova E.Y. Vibrissectomy during early ontogenesis in rats disturbs the functional properties of cortical projection neurons. Neuroscience and Behavioral Physiology. 2001. V. 31. N. 2. P. 153-156. DOI: 10.1023/A:1005204005811
- Sitnikova E.Y. Vibrissectomy in rats in early ontogenesis disrupts the functional properties of projection cortical neurons. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2000. V. 50. N. 8. P. 138-142.
- Sitnikova E.Y. The effects of restricting afferent input during early ontogenesis on evoked activity of projection neurons depend on the maturity of the sensory inputs. Neuroscience and Behavioral Physiology. 2000. V. 30. N. 6. P. 645-648. DOI: 10.1023/A:1026642615161
- Kudryashov I.E., Kudryashova I.V., Sitnikova E.Y., Raevsky V.V. The influence of deafferentation of the forelimb in early postnatal ontogenesis on the formation of synaptic transmission in the hippocampus. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1999. V. 49. N. 4. P. 629-634.
- Sitnikova E.Y. The influence of limitation of sensory influx in early ontogenesis on the induced activity of projection neurons depends on the degree of maturity of sensory inputs. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1999. V. 49. N. 3. P. 505-510.
- Sitnikova E.Y. Partial forelimb deafferentation during early ontogenesis in rats increases somatosensory cortex neuron reactivity. Neuroscience and Behavioral Physiology. 1999. V. 29. N. 2. P. 181-183. DOI: 10.1007/BF02465324
- Raevsky V.V., Alexandrov L.I., Vorobyeva A.D., Golubeva T.B., Korneeva E.V., Kudriashov I.E., Kudriashova I.V., Pigareva M.L., Sitnikova E.Y., Stashkevitch I.S. Sensory information - The major factor of ontogeny. Neuroscience and Behavioral Physiology. 1997. V. 27. N. 4. P. 455-461. DOI: 10.1007/BF02462947
- Grubov V., Sitnikova E.Y., Pavlov A.N., Koronovskii A.A., Hramov A.E. Recognizing of stereotypic patterns in epileptic EEG using empirical modes and wavelets. Physica A: Statistical Mechanics and its Applications. 2017. V. 486. P. 206-217. DOI: 10.1016/j.physa.2017.05.091
- Sysoeva M.V., Sitnikova E.Y., Sysoev I.V. Thalamo-cortical mechanisms of initiation, maintenance and termination of peak wave discharges in rats WAG / Rij. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 2. P. 103-112. DOI: 10.7868/S0044467716010123
- Sitnikova E.Y. Partial deafferentation of the forelimbs in rats in early ontogenesis increases the reactivity of neurons in the somatosensory cortex. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1997. V. 47. N. 6. P. 1051-1054.
- Grubova V.V., Koronovsky A.A., Sitnikova E.Y., Khramov A.E. Frequency-time analysis of characteristic patterns of activity of neural ensembles of the brain using continuous wavelet transform. Izvestija RAN. Serija Fizicheskaja. 2014. V. 78. N. 12. P. 1523-1527.
- Sitnikova E.Y., Hramov A.E., Grubov V.V., Ovchinnkov A.A., Koronovsky A.A. On-off intermittency of thalamo-cortical oscillations in the electroencephalogram of rats with genetic predisposition to absence epilepsy. Brain Research. 2012. V. 1436. P. 147-156. DOI: 10.1016/j.brainres.2011.12.006
- Runova A.E., Zhuravleva M.O., Sitnikova E.Y., Koronosvky A.A., Khromov A.E. Method for removing oculomotor artifacts on human EEG in recognition of ambiguous visual image. Informatsionno-upravlyajuchije sisstemy. 2017. V. 5. P. 105-112. DOI: 10.15217/issn1684-8853.2017.5.10
- Grubov V.V., Sitnikova E.Y., Koronkovsky A.A., Khromov A.E. Intermittent Intermittency Regime in the Behavior of Characteristic Oscillatory Patterns on an Epileptic Electroencephalogram. Izvestija RAN. Serija Biologicheskaja. 2015. V. 79. N. 12. P. 1527-1695.
- Trubov V.V., Koronovsky A.A., Sitnikova E.Y., Ivanov A.V., Khramov A.E. `Hardware and software systems for the analysis of brain electrical activity: monitoring of long-term processes in neurophysiology and ecology, clinical practice, creation of brain-computer interfaces. Innovatsionnaja dejatelnost. 2013. V. 2. N. 25. P. 152-161.
- Nazimov A.I., Pavlov A.N., Khromov A.E., Trubov V.V., Sitnikova E.Y., Koronovsky A.A. Adaptive method for recognizing characteristic oscillatory patterns based on wavelet transform. Radiotekhnika i electronika. 2013. V. 58. N. 8. P. 789-795.
- Grubova V.V., Sitnikova E.Y., Koronovsky A.A., Pavlov A.N., Khramov A.E. Automatic extraction and analysis of oscillatory patterns on non-stationary EEG signals using wavelet transform and empirical mode method. Izvestija RAN. Serija Fizicheskaja. 2012. V. 76. N. 12. P. 1520-1523.
- Nazimov A.I., Pavlov A.N., Hramov A.E., Grubov V.V., Sitnikova E.Y., Koronovskii A.A. Adaptive wavelet transform-based method for recognizing characteristic oscillatory patterns. Journal of Communications Technology and Electronics. 2013. V. 58. N. 8. P. 790-795. DOI: 10.1134/S1064226913070115