Laboratory of Human Higher Nervous Activity

The main areas of research

Neurophysiological basis of human cognitive functions in healthy and pathological brain

Perception

Attention

Emotions

Memory

Thinking

Consciousness (levels, content, form)

Basic research methods

Evoked potentials

EEG

Vegetative indices

fMRI (behavior and resting state)

Psychometric tests

History

The laboratory of higher nervous activity of a person was organized at the Institute in 1987. Its task was defined as studying the physiological foundations of consciousness. From 1987 to 2012, the laboratory was headed by prof. A.M. Ivanitsky, who had developed the theory of information synthesis shortly before. The theory was based on a study of the physiological processes underlying sensations. Following this theory, psychic (subjectively experienced) phenomena arise as a result of the return of excitation to areas of initial projections, comparison, and synthesis in the cortex of new information with previous extracted from memory and comes from centers of motivation.

Список сотрудников

Publication list

Papers

Sysoeva O.V., Tonevitsky A.G., Wackermann J. Genetic determinants of time perception mediated by the serotonergic system. PloS One. 2010. V. 5. N. 9. e12650. DOI: 10.1371/journal.pone.0012650
Ukraintseva Y.V., Sshchegolevskii N.V., Korshunov V.A., Bazyan A.S., Kucheryanu V.G., Ugryumov M.V. Modeling of the presymptomatic stage of parkinsonism in mice: Analysis of dopamine release in the striatum. Neurochemical Journal. 2010. V. 4. N. 2. P. 142-147. DOI: 10.1134/S1819712410020108
Verkhlyutov V.M., Gapienko G.V., Ushakov V.L., Portnova G.V., Verkhlyutova I.A., Anisimov N.V., Pirogov Y.A. MRI morphometry of the cerebral ventricles in patients with attention deficit hyperactivity disorder. Neuroscience and Behavioral Physiology. 2010. V. 40. N. 3. P. 295-303. DOI: 10.1007/s11055-010-9256-x
Verkhlyutov V.M., Gapienko G.V., Ushakov V.L., Portnova G.V., Verkhlyutova I.A., Anisimov N.V., Pirogov Y.A. MRI morphometry of the brain ventricles in patients with attention-deficit hyperactivity disorder. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2009. V. 59. N. 1. P. 34-44.
Verkhlyutov V.M., Ushakov V.L., Strelets V.B. Decrease in N170 evoked potential component latency during repeated presentation of face images. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2009. V. 59. N. 3. P. 307-317.
Strelets V.B., Garakh Z.V. Electrophysiological indicators of the effect of atypical antipsychotics on cognitive function in patients with schizophrenia. Tekhnologii Zhyvikh sistem. 2009. V. 1. N. 7. P. 37-45.
Strelets V.B., Garakh Z.V. Cognitive Dysfunction in Schizophrenia. Vestnik RGNF. 2009. V. 1. N. 54. P. 130-137.
Shkolnik T.K., Lushchekina E.A., Kulikov M.A., Airapetiants M.G. Comparison of parameters of stress and trait anxiety in teenagers who are brought up in full, incomplete families, and families with the replaced parents. Zhurnal Vysshei Nervnoi Deiatelnosti. 2009. V. 59. N. 2. P. 162-170.
Ivanitsky A.M., Ivanitsky G.A., Sysoeva O.V. Brain science: On the way to solving the problem of consciousness. International Journal of Psychophysiology. 2009. V. 73. N. 2. P. 101-108. DOI: 10.1016/j.ijpsycho.2009.02.004
Sysoeva O.V., Maluchenko N.V., Smirnov K.S., Shleptsova V.A., Ivanitsky A.M., Tonevitsky A.G. Peculiarities of brain information processing in persons with different serotonin transporter gene variants. Bulletin of Experimental Biology and Medicine. 2009. V. 148. N. 5. P. 731-734. DOI: 10.1007/s10517-010-0803-9
Sysoeva O.V., Maluchenko N.V., Timofeeva M.A., Portnova G.V., Kulikova M.A., Tonevitsky A.G., Ivanitsky A.M. Aggression and 5HTT polymorphism in females: Study of synchronized swimming and control groups. International Journal of Psychophysiology. 2009. V. 72. N. 2. P. 173-178. DOI: 10.1016/j.ijpsycho.2008.12.005
Rebreikina A.B., Novototsky-Vlasov V.Y., Strelets V.B. Processing of visually presented verbal stimuli in evoked potentials. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2008. V. 58. N. 3. P. 294-301.
Tkachenko O.N., Frolov A.A., Verkhlyutov V.M. Application of boundary element method for more accurate localization of EEG dipole sources. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2008. V. 58. N. 2. P. 247-254.
Ilyuchenok I.R., Sysoeva O.V., Ivanitsky A.M. Two semantic systems in the brain for rapid and slow differentiation of abstract and concrete words. Neuroscience and Behavioral Physiology. 2008. V. 38. N. 9. P. 963-970. DOI: 10.1007/s11055-008-9083-5
Kulikova M.A., Maluchenko N.V., Timofeeva M.A., Shlepzova V.A., Schegolkova J.V., Sysoeva O.V., Ivanitsky A.M., Tonevitsky A.G. Effect of functional catechol-O-methyltransferase Val158Met polymorphism on physical aggression. Bulletin of Experimental Biology and Medicine. 2008. V. 145. N. 1. P. 62-64. DOI: 10.1007/s10517-008-0006-9
Airapetiantz M.G., Shkolnik T.K., Lushchekina E.A. Comparison of parameters of stress and trait anxiety scores in teenagers brought up in socially favorable and socially adverse conditions. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2007. V. 57. N. 3. P. 261-267.
Illuchenok I.R., Sysoeva O.V., Ivanitsky A.M. Two semantic brain systems for rapid and slow differentiation of the abstract and concrete words. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2007. V. 57. N. 5. P. 566-575.
Malyuchenko N.V., Sysoeva O.V., Vedyakov A.M., Timofeeva M.A., Portnova G.V., Ivanitsky A.M., Tonevitsky A.G., Kirpichnikov M.P. Effect of 5HTT genetic polymorphism on aggression in athletes. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2007. V. 57. N. 3. P. 276-281.
Portnova G.V., Sysoeva O.V., Maliuchenko N.V., Timofeeva V.A., Kulikova M.A., Tonevitsky A.G., Kirpichnikov M.P., Ivanitsky A.M. Genetic basis of time perception in athletes. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2007. V. 57. N. 4. P. 450-460.
Portnova G.V., Sysoeva O.V., Maluchenko N.V., Timofeeva M.A., Kulikova M.A., Tanevitsky A.G., Kirpichnikov M.P., Ivanitsky A.M. The genetic basis of time perception in athletes. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2007. V. 57. N. 4. P. 461-471.
Stavtsev A.Y., Ushakov V.L., Verkhlyutov V.M. Modeling the effect of the layer thickness and tissue conductivities of the head and the brain on the EEG potentials using finite element method. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2007. V. 57. N. 6. P. 742-752.
Strelets V.B., Novototsky-Vlasov V.Y., Garakh Z.V., Zheligovsky V.A., Kaplan A.Y. The multipleparameter combinatory analysis of EEG rhythms in norm and at schizophrenia. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2007. V. 57. N. 6. P. 684-691.
Surnov K.G., Balashova E.Y., Kovyazina M.S., Portnova G.V. Watches as a cultural subject: an attempt at psychological analysis. Voprosy Psikhologii. 2007. V. 1. N. 3. P. 99-106.
Crosby M.A., Goodman J.L., Strelets V.B., Zhang P., Gelbart W.M. FlyBase: Genomes by the dozen. Nucleic Acids Research. 2007. V. 35. N. SUPPL. 1. D486-D491. DOI: 10.1093/nar/gkl827
Mnatsakanian E.V., Tarkka I.M. Spatio-temporal modeling of evoked brain activity during memory encoding and target comparison in visual tasks. Brain Topography. 2007. V. 20. N. 1. P. 21-30. DOI: 10.1007/s10548-007-0027-0
Portnova G.V., Sysoeva O.V., Balashova E.U. Neuropsychological and psychophysiological problems of time perception for young and old people. Novel Moleculat Strategies to treat. Neurodegenerative Diseases. 2007. V. ??. ??.
Strelets V.B., Garakh Z.V., Novototskii-Vlasov V.Y. Comparative study of the gamma rhythm in normal conditions, during examination stress, and in patients with first depressive episode. Neuroscience and Behavioral Physiology. 2007. V. 37. N. 4. P. 387-394. DOI: 10.1007/s11055-007-0025-4
Sysoeva O.V., Ilyuchenok I.R., Ivanitsky A.M. Rapid and slow brain systems of abstract and concrete words differentiation. International Journal of Psychophysiology. 2007. V. 65. N. 3. P. 272-283. DOI: 10.1016/j.ijpsycho.2007.05.003
Verkhlyutov V.M., Shuchkin Y.A., Ushakov V.L., Strelets V.B., Pirogov Y.A. Estimation of localization and dipole moment of alpha- and theta-rhythm sources by cluster analysis in healthy subjects and schizophrenics. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2006. V. 56. N. 1. P. 47-55.
Strelets V.B., Garakh Z.V., Korsakova N.K., Magomedov R.A., Magomedova M.V., Novototsky-Vlasov V.Y., Rebreikina A.B. Features of the gamma rhythm of the EEG and some neuropsychological disorders in patients with schizophrenia. Sotsialnaja i Klinicheskaja Psikhiatrija. 2006. V. 16. N. 4. P. 55-60.
Strelets V.B., Garakh Z.V., Novototsky-Vlasov V.Y. Comparative study of the gamma-rhythm in the norm, pre-examination stress and patients with the first depressive episode. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2006. V. 56. N. 2. P. 219-227.
Strelets V.B., Garakh Z.V., Novototsky-Vlasov V.Y. Comparative study of the gamma rhythm in normal, exam stress and in patients with the first episode of depression. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2006. V. 56. N. 2. P. 219-227.
Strelets V.B., Rebreikina A.B. Psychophysiological mechanisms of verbal information processing. Vestnik RGNF. 2006. V. 1. N. 3. P. 194-202.
Strelets V.B., Rebreikina A.B. Evoked potentials for events with different types of word processing. Vestnik RGNF. 2006. V. 3. N. 44. P. 194-202.
Strelets V.B., Garakh Z.V., Novototskii-Vlasov V.Y., Magomedov R.A. Relationship between EEG power and rhythm synchronization in health and cognitive pathology. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 6. P. 655-662. DOI: 10.1007/s11055-006-0070-4
Mnatsakanian E.V., Iljuchenik I.R., Ivanitsky G.A., Ivanitsky A.M. Dipole models for the sources of late evoked potential components in verbal tasks for intermodal attention and memory in humans. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2005. V. 55. N. 3. P. 315-321.
Strelets V.B., Garakh Z.V., Novototsky-Vlasov V.Y., Magomedov R.A. Correspondence between spectral power and synchronization of the brain rhythms in the norm and cognitive pathology. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2005. V. 55. N. 4. P. 496-504.
Airapetiants M.G., Lushchekina E.A., Shkolnik T.K. Study of trait anxiety in children with different profiles of lateral organization after early social deprivation. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2004. V. 54. N. 2. P. 225-228.
Orekhov Y.V., Golikova Z.V., Strelets V.B. Psychophysiologic parameters of reproducing emotions in healthy subjects and patients during the first episode of depression. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2004. V. 54. N. 5. P. 612-619.
Strelets V.B., Magomedov R.A., Golikova Z.V., Novototsky-Vlasov V.Y. Spectral power and cortical interactions in the beta2 rhythm in normal subjects and schizophrenic patients. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2004. V. 54. N. 2. P. 229-236.
Mnatsakanian E.V., Tarkka I.M. Familiar-face recognition and comparison: Source analysis of scalp-recorded event-related potentials. Clinical Neurophysiology. 2004. V. 115. N. 4. P. 880-886. DOI: 10.1016/j.clinph.2003.11.027
Golikova Z.V., Strelets V.B. Development of examination stress in subjects with various levels of cortical activation. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2003. V. 53. N. 6. P. 697-704.
Reutov V.P., Sorokina E.G., Pinelis V.G., Samosudova N.V., Larionova E.V., Filippova N.A., Kositsyn N.S. Nerve cell resistance to toxic doses of sodium nitrite compounds in warm-blooded and cold-blooded animals. Vesti Natsionalnoj Academii Nauk Belarusi. Serija Mediko-Biologicheskikh Nauk. 2003. V. 1. N. 1. P. 75-78.
Strelets V.B. Problems of schizophrenia discussed at the 11th International Congress on Psychophysiology. July 29-August 3 2002, Montreal, Canada). Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2003. V. 53. N. 2. P. 255-256.
Martynova O.V., Kirjavainen J., Cheour M. Mismatch negativity and late discriminative negativity in sleeping human newborns. Neuroscience Letters. 2003. V. 340. N. 2. P. 75-78. DOI: 10.1016/S0304-3940(02)01401-5
Mnatsakanian E.V., Tarkka I.M. Matching of familiar faces and abstract patterns: Behavioral and high-resolution ERP study. International Journal of Psychophysiology. 2003. V. 47. N. 3. P. 217-227. DOI: 10.1016/S0167-8760(02)00154-X
Strelets V.B., Faber P.L., Golikova J., Novototsky-Vlasov V., Koenig T., Gianotti L.R., Gruzelier J.H., Lehmann D. Chronic schizophrenics with positive symptomatology have shortened EEG microstate durations. Clinical Neurophysiology. 2003. V. 114. N. 11. P. 2043-2051. DOI: 10.1016/S1388-2457(03)00211-6
Tarkka I.M., Mnatsakanian E.V. Functional specialization in the human frontal cortex observed during task anticipation. Neuropsychobiology. 2003. V. 48. N. 2. P. 102-110. DOI: 10.1159/000072885
Rusalova M.N., Kostunina M.B., Kulikov M.A. The spatial distribution of asymmetry coefficients of the brain bioelectric activity while experiencing negative emotions. Rossijskij Fiziologicheskij Zhurnal im I M Sechenova. 2002. V. 88. N. 3. P. 318-323.
Strelets V.B., Golikova Z.V., Novototsky-Vlasov V.Y., Salmanov P.P., Samko N.N. Cortical interactions in the beta2-rhythm during examination stress. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2002. V. 52. N. 4. P. 417-427.