Laboratory of Human Higher Nervous Activity

The main areas of research

Neurophysiological basis of human cognitive functions in healthy and pathological brain

Perception

Attention

Emotions

Memory

Thinking

Consciousness (levels, content, form)

Basic research methods

Evoked potentials

EEG

Vegetative indices

fMRI (behavior and resting state)

Psychometric tests

History

The laboratory of higher nervous activity of a person was organized at the Institute in 1987. Its task was defined as studying the physiological foundations of consciousness. From 1987 to 2012, the laboratory was headed by prof. A.M. Ivanitsky, who had developed the theory of information synthesis shortly before. The theory was based on a study of the physiological processes underlying sensations. Following this theory, psychic (subjectively experienced) phenomena arise as a result of the return of excitation to areas of initial projections, comparison, and synthesis in the cortex of new information with previous extracted from memory and comes from centers of motivation.

Список сотрудников

Publication list

Papers

Verkhlyutov V.M., Burlakov E.O., Gurtovoy K.G., Vvedensky V.L. Recognition of oral speech according to MEG data by covariance filters. Zh Vyssh Nerv Deiat I P Pavlova. 2023. V. 73. N. 6. P. 800-808. DOI: 10.31857/S0044467723060126
Kostanian D., Kleeva D., Soghoyan G., Rebreikina A.B., Sysoeva O.V. Opposite effects of rapid auditory stimulation on tetanized and non-tetanized tone of adjacent frequency: Mismatch negativity study. PloS One. 2023. V. 18. N. 8. e0289964. DOI: 10.1371/journal.pone.0289964
Mayorova L.A., Portnova G.V., Skorokhodov I. Cortical Response Variation with Social and Non-Social Affective Touch Processing in the Glabrous and Hairy Skin of the Leg: A Pilot fMRI Study. Sensors (Basel, Switzerland). 2023. V. 23. N. 18. P. 7881. DOI: 10.3390/s23187881
Medvedeva A., Portnova G.V., Sysoeva O.V. Lower loss rate of serotonergically modulated neuronal accumulator for time in patients with major depressive disorder. Journal Of Psychiatric Research. 2023. V. 165. P. 345-351. DOI: 10.1016/j.jpsychires.2023.08.005
Medvedeva T.M., Sysoeva O.V., Sysoev I.V., Vinogradova L.V. Intracortical functional connectivity dynamics induced by reflex seizures. Experimental Neurology. 2023. V. 368. P. 114480. DOI: 10.1016/j.expneurol.2023.114480
Mitiureva D., Bobrov P.D., Rebreikina A.B., Sysoeva O.V. An inclusive paradigm to study mu-rhythm properties. International Journal Of Psychophysiology. 2023. V. 190. P. 42-55. DOI: 10.1016/j.ijpsycho.2023.05.353
Portnova G.V., Skorohodov I.V., Mayorova L.A. The Levels of Auditory Processing during Emotional Perception in Children with Autism. Journal of Integrative Neuroscience. 2023. V. 22. N. 5. P. 112. DOI: 10.31083/j.jin2205112
Rebik A.A., Broshevitskaya N., Kuzhuget S., Aleksandrov P., Abbasova K., Zaichenko M.I., Midzyanovskaya I.S. Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky–Molodkina Rats. Biomedicines. 2023. N. 11. P. 2566. DOI: 10.3390/biomedicines11092566
Sysoeva O.V., Maximenko V., Kuc A., Voinova V., Martynova O.V., Hramov A. Abnormal spectral and scale-free properties of resting-state EEG in girls with Rett syndrome. Scientific Reports. 2023. V. 13. N. 1. P. 12932. DOI: 10.1038/s41598-023-39398-7
Talantseva O.I., Portnova G.V., Romanova D.Y., Martynova O.V., Sysoeva O.V., Grigorenko E.L. Does the Potocki-Lupski Syndrome Convey the Autism Spectrum Disorder Phenotype? Case Report and Scoping Review. Journal Of Personalized Medicine. 2023. V. 13. N. 3. P. 439. DOI: 10.3390/jpm13030439
Verkhlyutov V.M. Traveling waves of MEG somatosensory evoked responses. ZENODO. 2023. V. 7556979. DOI: 10.5281/zenodo.7556979
Verkhlyutov V.M., Burlakov E.O., Vvedensky V.L., Gurtovoy K.G., Ushakov V.L. Recognition of Spoken Words from MEG Data Using Covariance Patterns. Studies in Computational Intelligence,. 2023. V. 1120. P. 165-172. DOI: 10.1007/978-3-031-44865-2_18
Verkhlyutov V.M., Vvedensky V.L., Gurtovoy K.G., Burlakov E.O., Martynova O.V. Speech recognition from MEG data using covariance filters. bioRxiv. 2023. V. 546174v2. DOI: 10.1101/2023.06.22.546174
Vvedensky V.L., Verkhlyutov V.M., Gurtovoy K.G. Permanent Sharp Switches in Brain Waves During Spoken Word Recognition. Studies in Computational Intelligence,. 2023. V. 1120. 135–140. DOI: 10.1007/978-3-031-44865-2_14
Larionova E.V., Garakh Z.V., Zaytseva Y.S. MU-RHYTHM IN CONTEMPORARY RESEARCH: THEORETICAL AND METHODOLOGICAL ASPECTS. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2022. V. 72. N. 1. 3–27. DOI: 10.31857/S0044467722010051
Burlakov E., Verkhlyutov V., Ushakov V. A Simple Human Brain Model Reproducing Evoked MEG Based on Neural Field Theory. Studies in Computational Intelligence. 2022. V. 1008. P. 109-116. DOI: 10.1007/978-3-030-91581-0_15
Larionova E.V., Martynova O.V. Frequency Effects on Spelling Error Recognition: An ERP Study. Frontiers In Psychology. 2022. V. 13. P. 834852. DOI: 10.3389/fpsyg.2022.834852
Liaukovich K., Sazhin S., Bobrov P., Ukraintseva Y. Event-Related Potential Study of Recovery of Consciousness during Forced Awakening from Slow-Wave Sleep and Rapid Eye Movement Sleep. Int. J. Mol. Sci.. 2022. V. 23. N. 19. P. 11785. DOI: 10.3390/ijms231911785
Maslennikova A.V., Portnova G.V., Martynova O.V. Brain oscillatory patterns of affective prosody perception in children with autism spectrum disorder. Research in Autism Spectrum Disorders. 2022. V. 96. DOI: 10.1016/j.rasd.2022.101993
Neklyudova A.K., Smirnov K.S., Rebreikina A.B., Martynova O.V., Sysoeva O.V. Electrophysiological and Behavioral Evidence for Hyper- and Hyposensitivity in Rare Genetic Syndromes Associated with Autism. Genes. 2022. V. 13. N. 4. P. 671. DOI: 10.3390/genes13040671
Panfilova E.A., Burlakov E.O., Verkhlyutov V.M. Traveling waves in the resting state are initiated by the connectome. Frontiers Event Abstract 6th HBP Student Conference on Interdisciplinary Brain Research. 2022. P. 56-59. DOI: 10.3389/978-2-88971-014-0
Portnova G.V., Neklyudova A.K., Voinova V., Sysoeva O.V. Clinical EEG of Rett Syndrome: Group Analysis Supplemented with Longitudinal Case Report. Journal Of Personalized Medicine. 2022. V. 12. N. 12. P. 1973. DOI: 10.3390/jpm12121973
Rebik A.A., Riga V.D., Smirnov K.S., Sysoeva O.V., Midzyanovskaya I.S. Social Behavioral Deficits in Krushinsky-Molodkina Rats, an Animal Model of Audiogenic Epilepsy. Journal Of Personalized Medicine. 2022. V. 12. N. 12. P. 2062. DOI: 10.3390/jpm12122062
Verkhlyutov V.M. MEG data during the presentation of Gabor patterns and word sets. ZENODO. 2022. V. 7458233. DOI: 10.5281/zenodo.7458233
Verkhlyutov V.M., Burlakov E.O. MEG simulations using local propagation of traveling waves calculated using neural field equations. ZENODO. 2022. V. 7548183. DOI: 10.5281/zenodo.7548183
Burlakov E.O., Verkhlyutov V.M., Malkov I.I., Ushakov V.L. Assessment of Cortical Travelling Waves Parameters Using Radially Symmetric Solutions to Neural Field Equations with Microstructure. Studies in Computational Intelligence. 2021. V. 925 SCI. DOI: 10.1007/978-3-030-60577-3_5
Kleeva D.F., Rebreikina A.B., Soghoyan G.A., Kostanian D.G., Neklyudova A.K., Sysoeva O.V. Generalization of sustained neurophysiological effects of short-term auditory 13-Hz stimulation to neighbouring frequency representation in humans. The European Journal Of Neuroscience. 2021. V. 55. N. 1. P. 175-188. DOI: 10.1111/ejn.15513
Liaukovich K., Ukraintseva Y.V., Martynova O.V. Implicit auditory perception of local and global irregularities in passive listening condition. Neuropsychologia. 2021. V. 165. P. 108129. DOI: 10.1016/j.neuropsychologia.2021.108129
Neklyudova A.K., Portnova G.V., Rebreikina A.B., Voinova V.Y., Vorsanova S.G., Iourov I.Y., Sysoeva O.V. 40-Hz Auditory Steady-State Response (ASSR) as a Biomarker of Genetic Defects in the SHANK3 Gene: A Case Report of 15-Year-Old Girl with a Rare Partial SHANK3 Duplication. International Journal Of Molecular Sciences. 2021. V. 22. N. 4. P. 1898. DOI: 10.3390/ijms22041898
Portnova G.V., Maslennikova A.V., Zakharova N.V., Martynova O.V. The Deficit of Multimodal Perception of Congruent and Non-Congruent Fearful Expressions in Patients with Schizophrenia: The ERP Study. Brain Sciences. 2021. V. 11. N. 1. P. 96. DOI: 10.3390/brainsci11010096
Smirnov K.S., Stroganova T., Molholm S., Sysoeva O.V. Reviewing Evidence for the Relationship of EEG Abnormalities and RTT Phenotype Paralleled by Insights from Animal Studies. International Journal Of Molecular Sciences. 2021. V. 22. N. 10. P. 5308. DOI: 10.3390/ijms22105308
Soghoyan G., Ledovsky A., Nekrashevich M., Martynova O.V., Polikanova I., Portnova G.V., Rebreikina A.B., Sysoeva O.V., Sharaev M. A Toolbox and Crowdsourcing Platform for Automatic Labeling of Independent Components in Electroencephalography. Frontiers In Neuroinformatics. 2021. V. 15. P. 720229. DOI: 10.3389/fninf.2021.720229
Gladun K.V. Higuchi Fractal Dimension as a Method for Assessing Response to Sound Stimuli in Patients with Diffuse Axonal Brain Injury. Covremennye Tehnologii v Medicine. 2020. V. 12. N. 4. P. 63-71. DOI: 10.17691/stm2020.12.4.08
Larionova E.V., Rebreikina A.B. EVENT-RELATED SYNCHRONIZATION/DESYNCHRONIZATION OF ALPHA AND THETA WAVES DURING STROOP TASK PERFORMANCE IN ABSTINENT CANNABIS USERS. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova . 2020. V. 70. N. 2. 163–173. DOI: 10.31857/S0044467720020094
Rebreikina A.B., Larionova E.V., Martynova O.V. Event-related potentials during literacy. Journal of Modern Foreign Psychology. 2020. V. 9. N. 2. 21–33. DOI: 10.17759/jmfp.2020090202
Burlakov E.O., Zhukovskiy E.N., Verkhlyutov V.M. Neural field equations with neuron‐dependent Heaviside‐type activation function and spatial‐dependent delay. Mathematical Methods in the Applied Sciences. 2020. DOI: 10.1002/mma.6661
Garakh Z.V., Larionova E.V., Zaytseva Yu. Evoked EEG activity in semantic task performance in paranoid schizophrenia. PsyCh Journal. 2020. V. 9. N. 5. P. 760-763. DOI: 10.1002/pchj.391
Garakh Z.V., Novototsky-Vlasov V., Larionova E.V., Zaytseva Yu. Mu Rhythm Separation from the Mix with Alpha Rhythm: Principal Component Analyses and Factor Topography. Journal of Neuroscience Methods. 2020. V. 346. P. 108892. DOI: 10.1016/j.jneumeth.2020.108892
Gavron A.A., Deza-Araujo Y.I., Sharova E.V., Smirnov A., Knyazev G., Chelyapina-Postnikova M.V., Fadeeva L., Abdulaev A., Kulikov M.A., Zhavoronkova L.A., Boldyreva G.N., Verkhlyutov V.M., Pronin I. Group and Individual fMRI Analysis of the Main Resting State Networks in Healthy Subjects. Neuroscience and Behavioral Physiology. 2020. V. 50. N. 3. P. 288-297. DOI: 10.1007/s11055-020-00900-7
Kozhukhov S.A., Ivanov R.S., Bugrova V.S., Verkhlyutov V.M., Ushakov V.L. Functional asymmetry of local connections in V1 and its impact on orientation tuning. Procedia Computer Science. 2020. V. 169. P. 620-639. DOI: 10.1016/j.procs.2020.02.201
Martynova O.V., Tetereva A.O., Balaev V., Portnova G.V., Ushakov V., Ivanitsky A.M. Longitudinal changes of resting-state functional connectivity of amygdala following fear learning and extinction. International Journal of Psychophysiology. 2020. V. 149. P. 15-24. DOI: 10.1016/j.ijpsycho.2020.01.002
Miasnikova A., Perevoznyuk G., Martynova O.V., Baklushev M. Cross-frequency phase coupling of brain oscillations and relevance attribution as saliency detection in abstract reasoning. Neuroscience Research. 2020. DOI: 10.1016/j.neures.2020.05.012
Portnova G., Girzhova I., Filatova D., Podlepich V., Tetereva A., Martynova O. Brain Oscillatory Activity during Tactile Stimulation Correlates with Cortical Thickness of Intact Areas and Predicts Outcome in Post-Traumatic Comatose Patients. Brain Sciences. 2020. V. 10. N. 10. P. 720. DOI: 10.3390/brainsci10100720
Portnova G.V., Tetereva A., Ivanitsky A.M., Martynova O.V., Liaukovich K.M. The effect of experimental conditions, the sample size and session duration on resting-state subjective experience. Psychology, Journal of the Higher School of Economics. 2020. V. 17. N. 3. P. 592-607. DOI: 10.17323/1813-8918-2020-3-592-607
Sharova E.V., Kotovich Ju.V., Deza-Araujo Y.I., Smirnov K.S., Gavron A.A., Fadeeva L.M., Chelyapina-Postnikova M.V., Alexandrova E.V., Vronkova L.A., Boldyreva G.N., Verkhlyutov V.M., Kornienko V.N., Pronin I.N. fMRI resting state networks visualization in patients with severe traumatic brain injury. Medical Visualization. 2020. V. 24. N. 1. P. 68-84. DOI: 10.24835/1607-0763-2020-1-68-84
Stroganova T.A., Komarov K.S., Sysoeva O.V., Goiaeva D.E., Obukhova T.S., Ovsiannikova T.M., Prokofyev A.O., Orekhova E.V. Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD. Molecular Autism. 2020. V. 11. N. 1. P. 100. DOI: 10.1186/s13229-020-00408-4
Sysoeva O.V., Molholm S., Djukic A., Frey H.P., Foxe J.J. Atypical processing of tones and phonemes in Rett Syndrome as biomarkers of disease progression. Transl Psychiatry. 2020. V. 10. N. 1. P. 188. DOI: 10.1038/s41398-020-00877-4
Tetereva A., Kartashov S., Ivanitsky A.M., Martynova O.V. Variance and Scale-Free Properties of Resting-State Blood Oxygenation Level-Dependent Signal After Fear Memory Acquisition and Extinction. Frontiers in Human Neuroscience. 2020. 14:509075.. DOI: 10.3389/fnhum.2020.509075
Tetereva A.O., Balaev V.V., Kartashov S.I., Ushakov V.L., Ivanitsky A.M., Martynova O.V. Asymmetry of amygdala resting-state functional connectivity in healthy human brain. Neuroreport. 2020. V. 31. N. 1. P. 17-21. DOI: 10.1097/WNR.0000000000001353
Ukraintseva Y.V. Selective slow-wave sleep suppression affects glucose tolerance and melatonin secretion. The role of sleep architecture. Sleep Medicine. 2020. DOI: 10.1016/j.sleep.2019.11.1254